Titanocene-Catalyzed Reaction of Alkenes and Dienes with Alkyl Halides and Chlorosilanes

Abstract

New catalytic reactions for regioselective introduction of alkyl and/or silyl functionalities to alkenes and dienes are described. These reactions proceed efficiently under mild conditions by the use of Cp₂TiCl₂ as a catalyst in the presence of Grignard reagents. The present study would provide a prototype for the practical use of alkyl halides and chlorosilanes in transition metal-catalyzed reactions. In these reactions, ate complexes of titanocene play important roles as the active species. The scope and limitations, as well as reaction pathways, are discussed.