有機スズ試薬を用いたカルボニル化合物のエナンチオ選択的ラジカル反応
2001 年 59 巻 6 号 p. 560-568
詳細
2001 年 59 巻 6 号 p. 560-568
Selected recent examples of enantioselective radical-mediated reactions of carbonyl compounds by use of organotin reagents are reviewed. Enantioselective reduction, allylations and cyclizations of α-halocarbonyl compounds promoted by chiral Lewis acids have met with success. Employment of chiral organotin hydrides has been also successful in yielding optically active compounds. Furthermore, hydrogen atoms and allyl groups can be transferred enantioselectively to radicals undergoing additions to α, β-unsaturated carbonyl compounds in the presence of chiral Lewis acids. β-Enantioselective radical additions catalyzed by chiral Lewis acids can be achieved. In addition, there are some cases where external achiral ligands show remarkable effects on asym-metric induction.
