Integrated Chemical Processの開発による合成プロセスの自動化
2001 年 59 巻 8 号 p. 732-741
詳細
2001 年 59 巻 8 号 p. 732-741
The automation of multi-step chemical processes has been realized. A new concept for one-pot processes has been advanced which enables integration of various types of reactions involving carbon-carbon bond formations and functional group modifications. In the meantime, an automated synthesizer to accommodate such one-pot processes has been devised. This machine allows us to reproduce usual bench work : treatment of air-sensitive materials, control of temperature from -78°C to 100°C within ± 0.1°C accuracy, and successive addition of reagents. Several examples which were successfully conducted on the machine are described.
