2002 年 60 巻 8 号 p. 794-799
The key issue of the present drug development is to find the lead compound in the minimum time and cost by using all kinds of new and traditional technology such as genomic drug discovery, random High Throughput Screening (HTS), virtual screening, combinatorial chemistry, X-ray crystal analysis, molecular modeling and so on. It is crucial to build up efficiently Chemical Compound Library with wide diversity to be applied to HTS for any kind of biological activity. University Compound Project at Foundation for Education of Science and Technology was started on February 2002, to use more efficiently not commercially-available domestic and abroad University Compounds (UC) for the drug development by building up the University Compound Data Base (UCDB). So far, 60 chemists at 35 universities and institutes, and 12 companies have joined to the project. The project has collected about 29, 000 UCDB available to the participating companies for the selection of UC and would add about 10, 000 UCDB every year.