Catalyzed Enantioselective Conjugate Addition Reactions of Strongly Coordinating Nucleophiles

Abstract

This article describes a new synthetic methodology developed in our institute, which produces enantiomers in the reactions using strongly coordinating nucleophiles under the catalysis of torelant chiral Lewis acid. The nickel (II) aqua complexes derived from DBFOX chiral ligand can successfully catalyze the conjugate addition reactions of thiols. Even under double catalytic conditions using catalytic amounts of both amines and the DBFOX - nickel (II) complexes, Michael addition reactions of active methylene compounds such as malononitrile and nitromethane can be effectively activated.