有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
イミダゾールC-ヌクレオシド誘導体の合成研究とヒスタミンH3およびH4リガンドへの応用
春沢 信哉荒木 理佐栗原 拓史
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2003 年 61 巻 7 号 p. 682-693

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Synthetic studies of imidazole C-nucleoside derivatives and their application to novel histamine H3- and H4-ligands are described, in which the following items are covered. 1) Stereoselective synthesis of imidazole C-nucleosides via diazafulvene intermediates. 2) Synthesis of tetrahydrofuranylimidazoles using efficient use of a PhSe group and its application to novel histamine H3-ligands. 3) Histamine H3- and H4-agonistic activities of imifuramine derivatives. 4) Efficient synthesis of imifuramine and its stereoisomer via diazafulvene intermediates. 5) Difference between diazafulvene cyclization and intramolecular Mitsunobu reaction of 1, 4-diols.

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