アジン系複素環化合物の合成とそれらの機能性分子への変換

抄録

We have focused on the synthesis of azine-type heterocyclic compounds and their conversion into useful functional molecules. In this article, the following points were reviewed. 1) 6-Amino-2, 3-dimorpholinoquinoxalines bearing the amino acid residues at C-6 position were found to be highly-sensitive fluorescent chiral derivatization reagents. 2) A new tripodal heterocyclic hexadentate ligand, in which three sets of 3-hydroxy-4 (1H) -pyridinone and ethyleneoxy chain are linked to tris (carboxyethoxymethyl) ethane was synthesized. The allosteric binding of alkali metal ions to a pseudocryptand formed by the ligand and Ga (III) was discussed. 3) Hydroxyazine-type linear and cyclic hexapeptides were newly synthesized. The iron (M) complex-forming tendency, the absolute configuration, the stability constant, the iron (III) removal from human transferrin, and the growth-promotion activity were discussed. 4) Oxovanadium complexes of 3-hydroxy-4 (1H) -pyridinones were synthesized. The spectroscopic characterization of the complexes was carried out on the basis of ¹H-, ⁵¹V-NMR, IR, UV-VIS, FAB MS, ESI MS and ESR spectra, and cyclic voltammetry (CV). Further, an extremely high insulin-mimetic activity of bis (1, 4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato) zinc (II) complex was also discussed.