Abstract
Herein are described the first total syntheses of some bioactive compounds, which have been accomplished in my laboratories by a variety of strategies and methodologies to clarify their structure-activity relationships and to create practically useful lead compounds for new medicines. The target molecules are antibiotics (tylosin, oleandomycin and tetracycline), antifungals (nanaomycin D and kalafungin), antitumors (lymphostin and BE-54238 B), glycosidase inhibitors (cyclophellitol and nagstatin), peptidase inhibitors (pyrizinostatin, antipain and chymostatin), nervous systemaffecting products (deacetyl-caloporoside, calbistrin A and ES-242-4), mussel-attachment inhibitors (sideroxylonal B and C), anti-pylori (PC-3 and YM-30059), TPO receptor agonist (xanthocillin X dimethylether), and so on.
