有機合成化学協会誌
Online ISSN : 1883-6526
Print ISSN : 0037-9980
ISSN-L : 0037-9980
生命科学研究におけるスクアリン酸の活用とその進歩
品田 哲郎石田 稔和大船 泰史
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2007 年 65 巻 1 号 p. 30-43

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Squaric acid belongs to a class of oxocarbons and exhibits unique physicochemical properties, e.g., strong acidity, aromaticity, strained ring, electron deficiency, and metal chelating ability. Squaric acid has received considerable attention as a carboxylic acid mimic in medicinal chemistry, a novel chromophore in material science, a new chelator in inorganic chemistry, and a building block of quinones, triquinanes, cyclopentenones, and furanones in organic synthesis. Recently, squaric acid diesters are employed for a variety of applications in scientific fields as a linker to construct novel bioconjugate molecules. This review will describes recent progress on the use of squaric acid focused on bioorganic research.

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