Molecular Design Targeting Repeat Sequences in Human Genome

抄録

The small ligands that bind to the mismatched base pairs were found to stabilize the hairpin secondary structures of the repeat sequences found in the human genome. The trinucleotide repeats are the causatives of many neurological disorders.A whereas the telomere repeats are the sequence located in the 3' end of the human chromosome and stabilize the genome. The ligands described here induced the hairpin secondary structure upon binding to these repeat sequences.