Annals of Cancer Research and Therapy
Online ISSN : 1880-5469
Print ISSN : 1344-6835
ISSN-L : 1344-6835
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Volume 17, Issue 2
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Original Article
  • HLA-B54 is a candidate of response to Fluoropyrimidine plus PSK therapy in gastric cancer
    Kyoji Ogoshi, Kaichi Isono
    2009 Volume 17 Issue 2 Pages 40-44
    Published: August 25, 2009
    Released on J-STAGE: August 31, 2009
    DOIhttps://doi.org/10.4993/acrt.17.40
    JOURNAL FREE ACCESS
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    It is not well known that the correlation between HLA antigens and response to cancer therapy. To evaluate the correlation among patients' outcome, HLA antigens and therapies, we used the hierarchical clustering analysis (Ward method). We examined HLA antigens as biomarkers as well as models of gene polymorphism in 1753 gastric cancer patients followed over 25 years after treatment. Among these patients, we identified that HLA haplotypes; HLA-B54-Cw1-DQ4-DR4, might be restricting to Fluoropyrimidine drugs plus PSK therapy in gastric cancer. HLA haplotypes including HLA-B54 were candidate predictors for response to FPSK therapy in gastric cancer. HLAs will be useful biomarkers for response to therapy in Japanese patients.
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