The pharmacological actions of clindamycin-2-phosphate were investigated. Summary of pharmacological actions and minimal effective doses (MED) were as follows: inhibition on excised frog heart (2×10
-4g/ml), inhibition on excised guinea-pig atrium (10
-4g/ml), bradycardia on ECG of the rabbit (5mg/kg), acceleration on excised rabbit intestine (2×10
-4g/ml), dilation on excised rabbit ear vessels (10
-3 g/ml), acceleration on permeability of rabbit abdominal skin vessels (1,000 mcg) and acceleration on excised rat uterus (5×10
-4 g/ml). No effect on excised guinea-pig intestine and tracheal muscle was observed in doses up to 2×10
-4 g/ml and 5×10
-4 g/ml, respectively. Blood pressure of the rabbit fell in a dose of 20 mg/kg, however, respiration was not affect.
These actions were almost identical with those of clindamycin, and MED's were 2-200 timeslarger. These MED were 1,000-10,000 times larger than its minimum inhibitory concentrations and also 20-100 times larger than its maximum blood level.
Therefore, it is concluded that clindamycin-2-phosphate is one of the antibiotics which have much less pharmacological actions.
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