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Volume 27 (1974)
- Issue 6 Pages 707-
- Issue 5 Pages 601-
- Issue 4 Pages 429-
- Issue 3 Pages 271-
- Issue 2 Pages 69-
- Issue 1 Pages 1-
Predecessor
Volume 27, Issue 5
Displaying 1-9 of 9 articles from this issue
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YUTAKA KOBAYASHI, KYOJI AKAISHI, YOHNOSUKE KOBAYASHI, TOSHIKAZU NISHIO ...1974 Volume 27 Issue 5 Pages 601-619
Published: October 25, 1974
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSAbsorption and excretion of Amoxycillin Granule was studied in children, and its clinical effects were evaluated in 51 children with acute bacterial infections. The results were as follows:
1) Absorption of amoxycillin granule was faster, its peak of blood concentration slightly higher, and its urinary recovery rate slightly better than Amoxycillin Capsule.
2) Amoxycillin Granule, 30mg/kg/day in 4 divided doses, was given to the 51 children with the following diseases: 17 with urinary tract infection,. 27 with tonsillitis, 2 with scarlet fever and 5 with cervical lymphadenitis. Eight cases with urinary tract infections which were resistant to ABPC were excluded, and clinical effects were evaluated in 43 cases: excellent in 17 cases, good in 19, and poor in 7. The overalleffectiveness was 83.7%.
3) Among 51 cases 5 developed skin rash and 8 gastrointestinal symptoms. Of these 13 cases medication was discontinued in each one case with skin rash and diarrhea. In the remainder the reactions were mild and transient. No abnormal findings, which were thought to be due to administration of this antibiotic, were found in urinalysis, peripheral blood count and blood chemistry.
4) Taste and flavor of Amoxycillin Granule were well acceptable to the children.
5) Based on the above results it was concluded that this antibiotic had a good absorption and clinical effects and little adverse reactions and that it is a potent new antibiotic in the treatment of acute bacterial infections in children.View full abstractDownload PDF (2349K) -
NOBUYUKI GONDA, SACHU SHIMADA, IPPEI FUJIMORI, MASATAKA KATSU, RYONOSU ...1974 Volume 27 Issue 5 Pages 620-624
Published: October 25, 1974
Released on J-STAGE: May 17, 2013
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KIYOHITO SHIBATA, MICHITERU FUJII, NAGAO SHINAGAWA, YOSHITARO SUZUKI, ...1974 Volume 27 Issue 5 Pages 625-632
Published: October 25, 1974
Released on J-STAGE: May 17, 2013
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MATSUDA SEIJI, SOSHICHIRO MORI, MIKIHIKO TANNO, TAKASHI KASHIWAGURA1974 Volume 27 Issue 5 Pages 633-636
Published: October 25, 1974
Released on J-STAGE: May 17, 2013
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FUSANOSUKE YAMASAKU, SHOSAKU AOKI, GO SEKI, BUNYA ITO, TOMOO KAINUMA1974 Volume 27 Issue 5 Pages 637-642
Published: October 25, 1974
Released on J-STAGE: May 17, 2013
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MASAMITSU ISHIYAMA, SHOZO NAKAZAWA1974 Volume 27 Issue 5 Pages 643-652
Published: October 25, 1974
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSRifampicin (RFP), an antibiotic active against gram-positive bacteria including tubercule bacilli and gram-negative bacteria, has some weak points such as appearance of natural resistance in many bacteria, rapid development of resistance in vitro, etc.
In trials on the combination of RFP with various chemotherapeutics in order to overcome these weak points it was found that a combination of RFP and nalidixic acid (NA) showed strong synergism in some bacteria and suppression of the in vitro development of resistance.
A proper combination ratio of RFP and NA seemed to be 1: 4 from the results of in vitro and in vivo studies.
The acute toxicity of this combination was approximately same as that of NA alone in mice.
Colorimetry of cellular compornents revealed that the increase of DNA was more markedly inhibited in the cells of E. coli NIHJ treated with this combination than it was in the cells treated with NA alone.View full abstractDownload PDF (1404K) -
YUTAKA KOBAYASHI, KYOJI AKAISHI, TOSHIKAZU NISHIO, YONOSUKE KOBAYASHI, ...1974 Volume 27 Issue 5 Pages 653-663
Published: October 25, 1974
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
HIROSHI MINAMI, TOMOICHI NODA, MASARO YOSHINARI, ITSUKO NAKAO, YOKO UE ...1974 Volume 27 Issue 5 Pages 664-670
Published: October 25, 1974
Released on J-STAGE: May 17, 2013
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EIJI TERAO1974 Volume 27 Issue 5 Pages 671-674
Published: October 25, 1974
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSLividomycin (LVDM) was administered intramuscularly 1g daily for 4-6 days to 18 outpatientswith acute gonorrhea. The results are summarized as follows;
1) The effect of LVDM to subjective signs was excellent in 6 cases (33.3%), effective in 8 (44.4%) of 18 cases and the effective rate was 77.7%.
2) The effect to objective signs was excellent in 8 cases (44.4%) and effective in 8 (44.4%). Theeffective rate was 88.8%.
3) Overall efficacy of LVDM was excellent in 6 (33.3%) and effective in 10 (55.6%) of 18 cases. The total effective rate was 88.9%.4) No side effect was observed with the injection of LVDM.
5) It was evaluated, that LVDM was a useful antibacterial agent for acute gonorrhea.View full abstractDownload PDF (607K)
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