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Volume 28, Issue 1
Displaying 1-14 of 14 articles from this issue
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Acute toxicity of bleomycin ointment orally administered into mice, rats and dogsNASATOSHI TSUBOSAKI, KOUICHI ITO, KOUKICHI MIYAMOTO, TAKESHI TANAKA, T ...1975 Volume 28 Issue 1 Pages 1-2
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
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Subacute and chronic toxicity in rabbitsTAKESHI TANAKA, KOUKICHI MIYAMOTO, MASATOSHI TSUBOSAKI, TAKUMI YAMASHI ...1975 Volume 28 Issue 1 Pages 3-18
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
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Irritative effect of bleomycin ointment on eye mucous membrane and skinKOUKICHI MIYAMOTO, TAKESI TANAKA, SHOKO ISAWA, TAKUMI YAMASHITA, AKIRA ...1975 Volume 28 Issue 1 Pages 19-36
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
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YOSHIHARU MIKI, TOMOYUKI KAWATSU, HIROSHI MATSUDA, TETSUTARO YAMADA, A ...1975 Volume 28 Issue 1 Pages 37-43
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
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YUKO ICHODA, SHIHOKO YAMAGUCHI, TAKUMI YAMASHITA, OSAMU YOSHIOKA, AKIR ...1975 Volume 28 Issue 1 Pages 44-47
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
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YUTAKA KANAZAWA, TOSHIO KURAMATA1975 Volume 28 Issue 1 Pages 48-52
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
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IZUMI IHARA, TOSHIHIKO KONDO, MASAYA KAWAKAMI, TOMONORI MATSUMOTO, MIC ...1975 Volume 28 Issue 1 Pages 53-60
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSThe therapeutic potencies of colistin methanesulfonate (CLM) was assessed quantitatively in acute infection of mice with clinically isolated strains of Escherichia coli and Pseudomonas czeruginosa, and effect of different routes of administration was compared. There was no detectable difference in the therapeutic effect of CLM when intramuscular (im) or intravenous (iv) administration was initiated one hour after the infection. On the other hand, a significant difference in ED50 given by im and iv administrations was observed, indicating the superiority of iv administration, when the treatment started 4-6 hours after the infection. No difference in the therapeutic effect of polymyxin B (PMB) and tetracycline (TC) administered via either im or iv route was found even in the delayed administration. In contrast to PMB and TC, lower toxicity of CLM was determined when it was administered iv rather than im.View full abstractDownload PDF (1074K) -
KAZUFUTO FUKAYA, OTOHIKO KUNII, KEIMEI MASHIMO, OSAMU KITAMOTO1975 Volume 28 Issue 1 Pages 61-66
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSThe absorption and excretion of a new doxycycline solution for intravenous use (DOTC iv) were studied with the following results.
1. Serum levels following one shot intravenous injection of DOTC iv in glucose solution showed a good dose-response comparable with that of the same dose injection of pyrrolidinomethyltetracycline (PRM-TC).
The urinary excretion was also examined. In 200mg injection, nausea, general warm feeling, odor in mouth and tongue numbness were complained.
2. When DOTC iv was injected intramuscularly, the serum level did not reach the peak value and low level continued for a long time. Moderate local pain was complained at the site of injection.
3. The serum level following drip infusion of DOTC dry fill showed a dose-response as well. The local vein tolerated well.
4. No abnormalities were found in clinical and laboratory examinations in all volunteers.View full abstractDownload PDF (804K) -
YASUKO ISHIMURA, MASAAKI KURAMOTO, TSUNEO KATORI, SHIUNG-YI LEE, YOSHI ...1975 Volume 28 Issue 1 Pages 67-73
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS1) Normal intestinal microbial flora (NF) in feces of rats were examined before and after administration of gentamicin (GM). Although GM caused no influence on NF after 6 hours, the number of NF decreased markedly 24 hours after GM, viz., the count of coliforms, enterococci and lactobacilli was reduced to 1/10-1/100 of the control value whileproteus and fusobacteria declines in number down to 1/100-1/1,000 times as low as the control value.
2) The decreased count of NF tended to recover to some degree at the end of the 1st therapeutic week and the considerably recovered count continued thereafter indicating about 1/10 times as low as the control value until a 12-week experimental period, except that the count of lactobacilli returned to almost normal.
3) Susceptibility of coliforms isolated from GM-treated rats to GM was nearly equal to that of the bacteria isolated from the untreated control rats, which revealed no development of drug resistance to GM.
4) The increasing rate of body weight was higher in GM-treated rats than in the control, and the feed intake was consequently great in the former.View full abstractDownload PDF (1074K) -
YOSHIE KAJIMOTO, MASAAKI KURAMOTO, YASUKO ISHIMURA, TSUNEO KATORI, SHI ...1975 Volume 28 Issue 1 Pages 74-80
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSThe effect of gentamicin (GM) on the thyroid function was investigated in relation with its stimulating action to the growth of rats at a very small dose level. The results may be summarized as follows:
(1) Changes in 131I-uptake of the thyroid after administration of GM were unremarkable. The change in wet weight of the thyroid was also unremarkable. Therefore, GM may not affect the thyroid itself.
(2) GM-treated rats clearly showed a decrease in 131I-triiodothyronine resine sponge uptake (triosorb test) as compared with the control animals, viz., GM-treated rats indicated hypofunction of the thyroid.
(3) Thyroxin (T4) levels in the serum, determined by 125I-Tr4e sine sponge uptake (tetrasorb test), were apparently lower in the GM-treated rats than in the control.
(4) The thyroid function test for synthesis of the hormones revealed an increase in diiodotyrosine (DIT) value and decreases in 3, 5, 3'-triiodothyronine (T3) and T4 values in the GMtreated groups as compared with the values in the control.
(5) In view of the above results it was obvious that GM does not cause abnormalities on iodine-uptake, iodine oxidation, organic conversion to iodinated tyrosines, deiodination and thyroglobulin. In contrast, GM may induce abnormality on coupling reaction from DIT to T3 and T4 because the increase in DIT value and decreases in T, and T4 values are seen following administration of GM. The whole of these facts seems to play an important role in stimulation to growth of rats after administration of the drug.View full abstractDownload PDF (987K) -
MASAAKI KURAMOTO, YASUKO ISHIMURA, JUNKO MORIMOTO, SHIUNG-YI LEE, TSUN ...1975 Volume 28 Issue 1 Pages 81-84
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
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NAOMI NISHIDA, REIJI WATANABE, HIROKO KAWASHIMA, MIKIKO KAWAKITA, AKIR ...1975 Volume 28 Issue 1 Pages 85-87
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
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On safety of administration under anesthesiaSUSUMU ISHII, HIROKO YOKOTA1975 Volume 28 Issue 1 Pages 88-91
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
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1975 Volume 28 Issue 1 Pages 92-103
Published: February 25, 1975
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSDownload PDF (753K)
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