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Volume 29, Issue 11
Displaying 1-12 of 12 articles from this issue
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HISASHI TAKAHASHI, OSAMU KANEKO, NORIKO FUKUDA1976 Volume 29 Issue 11 Pages 955-957
Published: November 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSTen cases of various kinds of dermatoses underwent cephradine by injection. Two cases injected cephradine intramuscularly resulted in severe pain. Three of 4 cases with pyogenic skin infection revealed excellent results. Three cases were prevented from secondary infection. Adverse effects such as vertigo were avoided by lowering the speed of intravenous injection.
No abnormal findings of serum GOT and GPT levels after the completion of the treatment was noted in 7 of 8 cases, but one case which was administrated large dosis of corticosteroid concomitantly revealed elevated level in this finding.View full abstractDownload PDF (457K) -
MASAO OISHI, KENJI NISHIZUKA, MARIKO MOTOYAMA, TAKESHI OGAWA, MIKITO T ...1976 Volume 29 Issue 11 Pages 958-962
Published: November 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSBasic and clinical experiments were performed on intravenous cephradine (CED) in ophthalmological field. The results are summarized as follows.
1. Serum concentration: After intravenous- injection of 1.0g CED, in a single dose, to a healthy adult, the peak of serum level (34.0 μg/ml) was attained at 15 minutes, then decreased quickly to 2.3 μg/ml by 6 hours.
2. Ocular penetration in rabbit eye:
(1) Aqueous humor concentrations: The peak level of aqueous humor (13.45 μg/ml) was obtained at 30 minutes after intravenous injection of 50mg/kg, in a single dose. Aqueous/Serum ratio was 38.07%. After instillation of 5mg/ml solution of CED, 5 times every 5 minutes, the aqueous level was recognized 30 minutes and 1 hour, and no detectable 4 hours. After 50mg/0.5ml CED subconjunctival injection, in a single dose, the high aqueous levels were observed at 30 minutes and 1 hour, and still detectable 4 hours later.
(2) Ocular tissue concentrations: The ocular tissue concentrations at 30 minutes after intravenous injection of 50mg/kg CED were high in both outer and inner parts of the eye. After 4 hours, the tissue levels remained relatively high concentrations.
(3) Clinical results: Intravenous administration of 0.5, 1.0 or 2.0g CED 1 or 2 times daily revealed excellent or good effects in 8 of 12 cases, such as external hordeolum, internal hordeolum, lid abscess, chronic dacryocystitis, orbital abscess and corneal ulcer.
(4) Side effects: Three cases out of 12 complained burning sensation by intravenous injection of CED, but in neither case was it found necessary to withdraw the drugs. No severe side effects such as allergic reactions were observed. No abnormal findings in hepatic and renal function tests were observed.View full abstractDownload PDF (697K) -
TAKUZO ADACHI1976 Volume 29 Issue 11 Pages 963-967
Published: November 25, 1976
Released on J-STAGE: May 17, 2013
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OSAMU SEKINE, YOSHIMARU USUDA, KOZO HIGUCHI, MAKOTO WATANABE, FUSANOSU ...1976 Volume 29 Issue 11 Pages 968-972
Published: November 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS1) The half-life of serum concentration of cephradine (CED) in patients with normal renal function, was 30 minutes and it prolonged to 83 minutes when combined with probenecid.
2) In the patients with severely impaired renal function, mean serum concentration of CED was 33 mcg/ml 24 hours after 1g intravenous injection.
3) In clinical observations of 17 cases with infections of lung, urinary tract, and bile duct, the treatment with CED showed excellent results in 5 cases, good in 6, undetermined in 1. No remarkable side effect was observed.View full abstractDownload PDF (639K) -
ISAO SAITO, ROZOU MIYAMURA, YOSHIHITO BAN, YUKIMICHI KAWADA1976 Volume 29 Issue 11 Pages 973-978
Published: November 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSA new antibiotic cephradine was administered intravenously for 3-7 days at daily doses of 1.0-2.0g to 56 patients, including 39 cases of acute urinary tract infections, 13 of chronic urinary tract infections and 4 for postoperative prophylaxis.
Of 39 cases with acute urinary infections, definite response was seen in 35 cases and no definite response in 4 cases. Of 13 cases with chronic urinary tract infections, definite response was seen in 7 cases and no definite response in 6 cases. Good results were obtained clinically in 4 cases for prophylaxis of postoperative infections. No side effect was observed with cephradine throughout the experiment.View full abstractDownload PDF (668K) -
RYOJI UMINO, YASUHIDE YAMAMOTO1976 Volume 29 Issue 11 Pages 979-984
Published: November 25, 1976
Released on J-STAGE: May 17, 2013
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KEIICHI NAKAGAWA, KENTARO WATANABE, JUNZABURO KABE, TATSUO SUZUKI1976 Volume 29 Issue 11 Pages 985-990
Published: November 25, 1976
Released on J-STAGE: May 17, 2013
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YOSHIHIRO TAKISHITA, MICHIAKI KAWANO, EIRO TSUBURA1976 Volume 29 Issue 11 Pages 991-993
Published: November 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSCephradine (CED) was administered intravenously to the patients with respiratory infection or urinary tract infection with the dosage of 1.0-4.0g daily and their clinical effects were investigated.
Good clinical effects of CED were obtained in 5 of 8 cases with respiratory infections and in 2 of 5 cases with urinary tract infections.
Side effects were noted in 2 cases, but they improved rapidly by the cessation of the drug administration. One case developed skin eruption and the other case complained general burning, palpitation after intravenous injection and slight insomnia.
CED is seemed to be effective antibiotic for the respiratory as well as urinary tract infections clinically. However it was advisable that careful attention should be paid when CED is administered to the patient having drug allergy or nephropathy.View full abstractDownload PDF (366K) -
TETSUYA ISHII, TAKASHI YOKOYAMA, DAIZABURO KISHI, FUKUICHI FURUMOTO, H ...1976 Volume 29 Issue 11 Pages 994-998
Published: November 25, 1976
Released on J-STAGE: May 17, 2013
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TETSURO SHIDOU1976 Volume 29 Issue 11 Pages 999-1002
Published: November 25, 1976
Released on J-STAGE: May 17, 2013
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TOSHIAKI KAMIMURA, MINORU NISHIDA1976 Volume 29 Issue 11 Pages 1003-1006
Published: November 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSThough pyrrolnitrin is surpassed by clotrimazole in in vitro antitrichophyton activity against Trichophyton sp., the therapeutic effect of pyrrolnitrin against experimental trichophytosis in guinea pigs was more potent than that of clotrimazole. The detection of antifungal activity from topically treated guinea pigs suggests that pyrrolnitrin obtains higher concentrations than clotrimazole in dermal tissue.View full abstractDownload PDF (5596K) -
KIYOSHI MIKAWA, TADATSUGU ONO, YASUSHI OHAMA, MASARU SHIKANO, HIROKAZU ...1976 Volume 29 Issue 11 Pages 1007-1012
Published: November 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS
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