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Volume 29, Issue 4
Displaying 1-8 of 8 articles from this issue
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HAJIME SATO, OSAMU WATANABE, NAOMICHI FUJII, HIRONARI KOJIMA, YUICHI H ...1976 Volume 29 Issue 4 Pages 351-357
Published: April 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
YASUMICHI KATO, AKIRA SAITO, OSAMU YAJIMA, MASUMI TOMIZAWA, ICHIRO NAK ...1976 Volume 29 Issue 4 Pages 358-365
Published: April 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSBasic and clinical investigation on the intravenous administration of sulbenicillin in moderate dose (5-10 g daily) was carried out to evaluate its clinical effect in systemic infections due to gramnegative bacilli. The following results were obtained.
(1) In human subjects received 5g intravenous drip infusion, the peak blood levels were found at the end of infusion. In 6 cases with normal renal function (Ccr≥70 ml/min.) the peak blood level was 181 mcg/ml on the average and the half-life 1.1 hours, while in 3 cases with impaired renal function (Ccr<70 ml/min.) the peak level 216 mcg/ml and the half-life longer than 2 hours. The height of the peak level seemed to be subjected to the duration of infusion. The renal excretion of sulbenicllin was 55.2% on the average both in cases with normal and impaired renal functions.
(2) Sulbenicillin, 5-10g daily divided in 2 doses, was administered to 15 cases including 6 cases with acute pyelonephritis, 3 with acute cystitis, 3 with biliary tract infection, 2 with respiratory tract infection and 1 with acute prostatitis. All the cases except 3 cases with acute pyelonephritis had underlying diseases. Escherichia coli was isolated from 10 cases, Klebsiella from 2, Pseudomonas aeruginosa from 1, and unidentified gram-negative bacilli from 1. Eleven cases responded to the treatment, but 4 cases failed. In 11 cases with susceptible bacteria, 8 cases responded bacteriologically (2 cases recurred), and 3 cases failed to respond. A case with biliary tract infection due to E. coli did not respond to 5g daily treatment, but responded to 5g twice daily. Two cases due to organisms which were not inhibited by 200 mcg/ml in vitro did not respond to the treatment.
(3) A moderate decrease in red blood cell number and hemoglobin content was observed in one case. A transient increase in transaminase and alkaline phosphatase level was observed in other cases.View full abstractDownload PDF (948K) -
YUTAKA KANAZAWA, TOSHIO KURAMATA1976 Volume 29 Issue 4 Pages 366-376
Published: April 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSDrug-sensitivity of 70 strains of Y. enterocolitica and 24 of Y. pseudotuberculosis including reference strains and isolates from men or animals were determined by the agar plate-dilution method.
All the strains of Y. enterocolitica were relatively resistant to penicillins and cephalosporins, while all of Y. pseudotuberculosis were sensitive to both of the agents.
Most of the strains of both species excluding 13 resistant ones were sensitive to streptomycin. The resistant strains, however, were sensitive to other aminoglycoside antibiotics, i. e. kanamycin, paromomycin, gentamicin, tobramycin, dibekacin and amikacin.
All of the strains were sensitive to chloramphenicol.
Most of the strains excluding 3 resistant ones were highly sensitive to tetracycline. The resistant strains were also resistant to doxycycline and methacycline but not to minocycline.
All of them were resistant to erythromycin, to lincomycin and to novobiocin.
Most of them excluding 7 resistant strains were sensitive to sulfisoxazole.
All of them were sensitive to nalidixic acid, piromidic acid, and also to dihydroxymethylfuratrizine.
A new synthetic agent, fosfomycin showed a relatively wide range of activity to the strains, but none of resistant strains were noticed.
These resistant strains were all found in the isolates from men and animals but not in reference strains. Among these resistant strains, resistance patterns were as follows; TC, SM, SA in 3 of Y.enterocolitica, SM, SA in 3 of Y. enterocolitica and in 1 of Y. pseudotuberculosis, and SM in 3 of the both species, respectively.
As for polypeptide antibiotics, polymyxin B and colistin, some strains of the both species showed an uncontinuous susceptibility, i.e. inhibited growth at a certain lower concentration but growth at a higher concentration.
It was found, in the serial transfer with each I strain of the both species, that development of resistance in vitro were fairly rapid in colistin and in piromidic acid and next to in streptomycin or in kanamycin.View full abstractDownload PDF (1305K) -
HAJIME SATO, SUSUMU NAKAZAWA, OSAMU WATANABE, NAOMICHI FUJII, YUICHI H ...1976 Volume 29 Issue 4 Pages 377-384
Published: April 25, 1976
Released on J-STAGE: May 17, 2013
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TARO MAEDA1976 Volume 29 Issue 4 Pages 385-390
Published: April 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSForty-eight cases of otorhinolaryngological infections were treated with amoxicillin (AMPC) at a daily dose of 750 mg. The clinical and microbiological effects were studied, and the results were summarized as follows.
1. The subjects comprised 20 cases of otitis media, 10 of tonsillitis, 4 of sinusitis, 4 of chorditis, 2 of bronchitis, 5 of furuncle of the ear and 3 of furuncle of the nose. The clinical effective rate of AMPC was 82.9%, and the microbiological effective rate was 80.6%.
2. The effect of AMPC against strains isolated from the above diseases was also studied. The effective rate against Streptococcus was 91.6% and against Staphylococcus 83.3%.
3. Side effects were observed in 4 cases (one of diarrhea, two of abdominal discomfort and one of lingual pain), but none of them was so severe as the use of AMPC should have been discontinued.View full abstractDownload PDF (653K) -
MEIKI MATSUZAKI, HIROYOSHI MATSUMOTO, KENSUKE OCHIAI, YOSHIKATA TASHIR ...1976 Volume 29 Issue 4 Pages 391-402
Published: April 25, 1976
Released on J-STAGE: May 17, 2013
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MEIKI MATSUZAKI, KUNIKATSU ONODERA, ISAO OKAZAKI, KATSUJI KISHIMOTO, A ...1976 Volume 29 Issue 4 Pages 403-418
Published: April 25, 1976
Released on J-STAGE: May 17, 2013
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MEIKI MATSUZAKI, KUNIKATSU ONODERA, AKIRA NAKAJIMA, EIICHI KAMEI, MITS ...1976 Volume 29 Issue 4 Pages 419-429
Published: April 25, 1976
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS
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