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Volume 30, Issue 10
Displaying 1-13 of 13 articles from this issue
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TOSHIYUKI YAMAMOTO, KAZUHIKO OKADA, MASAO KASUGAI, MASAHITO KATO, SAKA ...1977 Volume 30 Issue 10 Pages 763-769
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
MASATOSHI KONNO, HARUO NANBU, YUKIO IZUMI, YUYA ISONO, SUSUMU NAKAZAWA ...1977 Volume 30 Issue 10 Pages 770-785
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
TATSUNORI SHIMIZU, NAGANORI SAITO, USUMI YOSHIDA, KAZUNORI TSUNEMATSU, ...1977 Volume 30 Issue 10 Pages 786-792
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
KAZUO TAKADA1977 Volume 30 Issue 10 Pages 793-801
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSS-6436 and S-6437 are preparations, of sustained release cefalexin, which consist of 30% of nonenteric coated granules and 70% of enteric coated ones. With oral administration of those preparations at b. i. d. regimen, good efficacies can be expected.
Those preparations were orally given to 39 patients with skin and soft tissue infections and 4 patients with other infections at the dose levels of 1,000-2,000mg/day (20-50mg/day in children) at 2 divided doses.
Excellent effect was observed in 30 patients and good effect was found in 13 patients. In 11 patients, usefulness of b. i. d. regimen was recognized. No side effects were observed.
From the above, S-6436 and 5-6437 are considered to be unique and useful preparations.View full abstractDownload PDF (1108K) -
HIROTO WASHIDA, KOUSUKE UEDA, HIDEKI WATANABE1977 Volume 30 Issue 10 Pages 802-805
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSS-6436 (a preparation consisting of 30% of non-enteric coated granules and 70% of enteric coated ones) was orally administered to the patients with acute pyelonephritis, and the following results were obtained:
1. Subjective symptoms: Very good in 13 cases (65%), good in 1, fair in 2 and poor in 4.
2. Urine finding: Very good in 13 cases (65%), good in 3 and poor in 4.
3. Disappearance of causative organisms: Organisms which were identified in the first examination were 17 strains of E. coli, one each of Pr. vulgalis, Klebsiellaand Staph. epidermidis, 3 of Strept. faecalis, and 3 of mixed infections. Very good effect was observed in 16 cases, good in 1, fair in 1 and poor in 2.
4. Total evaluation: Very good in 13 cases (65%), good in 4 (20%) and poor in 3 (15%).
5. Slight discomfort in abdomen was observed in only one patient, but disappeared by administration of digestive.
6. S-6436 was given to the patients with acute pyelonephritis twice a day expecting that the drug has satisfactory clinical efficacy.View full abstractDownload PDF (608K) -
TARO FURUSAWA, SHIGEKI TANAKA1977 Volume 30 Issue 10 Pages 806-818
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS1) Forty (40) patients with comparatively simple urinary tract infections were orally administered 1 g/day of sustained release cephalexin (S-6436) in two divided doses (after breakfast and dinner) for 7-14 days, and 20 patients complicated with chronic urinary tract infections or epididymitis were orally given 2 g/day of the drug in two divided doses (after breakfast and dinner) for 7-28 days.
Thirty six (90%) patients of the 40 receiving 1 g/day and seventeen (85%) of the 20 with 2g/ day satisfactorily responded to the drug.
2) Disappearance of organisms was observed in 43 patients (75.4%) of the 57 with urinary tract infections on whom bacteriological examination was conducted.
Three (7.0%) of the 43, however, recurred within 7 days after the treatment.
In six patients (10.5%) of the 57, the organisms were replaced.
3) Side effects such as gastrointestinal disturbance, allergic reactions, abnormality of blood picture, and impairments of renal and hepatic functions were examined and no such side effects were found except uriticaria in whole body was observed in only one patient with 1 g/day, which disappeared after discontinuation of the administration of the drug.View full abstractDownload PDF (1926K) -
KIYOHIDE NAKAGAWA, TAKUO FUKUYAMA, KENJI OISHI, TERUO KOUNAMI1977 Volume 30 Issue 10 Pages 819-824
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSS-6436 was orally given to the patients mainly with uncomplicated acute cystitis at two divided doses for 7 days with the following results:
1) One or 2 g/day of S-6436 were administered to the patients with 93.7% of effectiveness. There is almost no difference in effectiveness between 1 g and 2 g dosages.
2) Bacteria in urine disappeared in 74% of the patients treated and superinfection occurred in 22%. The disappearance of the bacteria was observed in 83.3% the patients with E. coli and 60% with Staph. epidermidis. The superinfection however was observed in 16.5% with E. coli and 33.3% with Staph. epidermidis. The disappearance of bacteria was observed in each one case with Klebsiella, Staph. aureus and Ps. aeruginosa. The superinfection was observed in 2 cases with Proteus.
3) Sensitivity tests on the organisms indicated that 94.4% of E. coli, 40% of Staph. epidermidis, Klebsiella and Staph. aureus were susceptible to the drug but Proteus and Ps. aeruginosa were not susceptible.
4) No remarkable side effects were observed, though digestive was used in several patients.
From the above results, S-6436 is considered to be a useful drug which is expected to have as much effectiveness as regular cephalexin at two divided doses after breakfast and dinner.View full abstractDownload PDF (805K) -
HIROSHI YAMAMOTO, SEISHIRO OIDA, AKIO OHTSUKI, TETSUO HOSODE, YOSHIKO ...1977 Volume 30 Issue 10 Pages 825-828
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSS-6436 is a new preparation of sustained release cephalexin. Twenty-eight patients with urinary tract infections were orally given 500 mg of S-6436 twice a day for about 7 days, and the following results were obtained:
1) Excellent clinical responses were observed in 8 cases, good in 18 cases and failure in 2 cases. Effectiveness was 93%.
2) As for the side effect, gastrointestinal symptoms were observed in one case out of 28 cases, but they disappeared after the completion of the treatment. No other side effects due to S-6436 were observed.
S-6436 has as much effectiveness and safety as compared with usual cephalexin preparations. The frequency of the administration of S-6436 is twice a day, which means that S-6436 is more convenient in giving it to patients than usual cephalexin preparations.View full abstractDownload PDF (630K) -
HIDEO URATA, KATSUNORI KOMEDA, HIROMI TOCHIGI, FUMIO MORISHITA, EIHO H ...1977 Volume 30 Issue 10 Pages 829-834
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSFortyeight patients with urinary tract infections including a case of acute prostatitis were treated with S-6436 and the following results were obtained:
1. Thirtyeight patients with acute cystitis resulted in 19 excellent, 15 good and 4 poor with effectiveness rate of 89.5%.
2. Ten patients with complicated urinary tract infections resulted in 1 excellent, 5 good and 4 poor with effectiveness rate of 60%.
3. Infecting organisms from 38 patients with acute cystitis were occupied by 28 strains of E. coll. The sensitivity rate of the infecting organisms to cephalexin was 96.4%.
4. In a few cases (6.25%) side effects of S-6436 were observed.
5. S-6436 will be one of the good firstchoice antibiotics for acute cystitis.View full abstractDownload PDF (814K) -
TOSHIAKI SAITO, YOSHINARI YAMADA1977 Volume 30 Issue 10 Pages 835-839
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSThe excretion of T-1220 in bile was evaluated in 4 patients with biliary tract diseases. The bile was collected for 6 hours after intravenous injection of T-1220. The maximal concentration in bile was 1,600mcg/ml at 0.5-1 hour after administration of 1g of T-1220 to 1 case. In 3 cases treated with 2g, the maximal concentration was 155-1,115mcg/ml at 2-3 hours after administration. Total excretion rates in bile after 0-6 hours were 0.5-7.2%.
T-1220 was applied clinically to 3 patients with biliary tract infections. Clinical results obtained were good in all cases.
No side effect was observed in all cases.View full abstractDownload PDF (705K) -
I. ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF CLINICAL ISOLATES OF SERRATIA MARCESCENSJUN IGARI, NOZOMU KOSAKAI, TOYOKO OGURI, MITSUHARU MURASE1977 Volume 30 Issue 10 Pages 840-846
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSFour hundred thirty eight isolations of S. marcescens from the variousclinical specimens in Juntendo University Hospital during the two year period from Jan. 1, 1973, until Dec. 31, 1974, were examined. Most of the isolates were recovered from urines and sputa. There were a few isolates from blood, bile and spinal fluid.
Antimicrobial susceptibility patterns of 9 antibiotics against 363 strains of S. marcescens isolated between Jan. 1, 1973 and July 31, 1974 were studied by using agar dilution method. The majority of the 140 isolates (>70%) from urines were resistant to streptomycin, kanamycin, tetracycline, chloram-phenicol, ampicillin, carbenicillin and sulbenicillin.
About two-third of the 223 isolates from the other specimens demonstrated resistance to streptomycin, kanamycin and carbenicillin, and more than 90% of the isolates to tetracycline, chloramphenicol and ampicillin. The isolates from the specimens except for urines had lower MICs of the above 7 anti-biotics than those from urines. Most of the isolates from both groups of the specimens were susceptible to gentamicin and dibekacin.
Further, antimicrobial activities of the 9 antibiotics were compared against pigmented and non-pigmented strains of S. marcescens from urines. A greater percentage of the non-pigmented than pigmented strains had higher MICs of streptomycin, kanamycin, tetracycline, chloramphenicol, ampicillin, carbenicillin, and sulbenicillin. All pigmented strains were inhibited by 12.5μg/ml for gentamicin and 81% was done by 12.5μg/ml for dibekacin. In contrast, ranges of MICs in non-pigmented strains were 0.39μg/ml to 400μg/ml for gentamicin and 0.39μg/ml to more than 400μg/ml for dibekacin.View full abstractDownload PDF (918K) -
II. CLINICAL SIGNIFICANCEJUN IGARI, NOZOMU KOSAKAI, TOYOKO OGURI, MITSUHARU MURASE1977 Volume 30 Issue 10 Pages 847-851
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSFor many years Serratia was considered incapable of causing human infections, but more recently this organism has been recognized as a cause of infections in patients with chronic debilitating diseases. The urinary tract has been the most common site of such infections, especially in patients using indwelling catheters for obstructive diseases.
This study was done to assess the incidence and significance of Serratia in urinary tract infec-tions and to investigate the clinical picture of the patients infected.
In the 2 year period, 1973-1974, there has been a striking increase in the incidence of S. marcescens isolated from the urine of hospitalized patients.
Urine from 53 patients showed S. marcescens in 124 cultures with more than 100,000 colonies per milliliter.
Most of the patients were suffered from urogenital diseases, disorders of central nervous system, or carcinomatosis. The percentage of postoperative patients was high. From these facts, the opportunistic or nosocomial nature of S. marcescens was demonstrated by the high percentage of patients with factors lowering host resistance.
As urinary tract instrumentations (with or without obstruction present) were performed on most of the patients, the correlation of catheterization with positive urine cultures for S. marcescens was very high. The route of infection could not determined, but it was suggested that catheterization or instrumentation of urinary tract was probably responsible.
All but threecases had received antibiotic treatment, mostly cephalosporins, sulbenicillin and ampicillin before S. marcescens was isolated.
This study showed that Serratia infections are an important component of hospital infection and no longer possible to consider this organism as nonpathogen.View full abstractDownload PDF (649K) -
SUSUMU NAKAZAWA, HAJIME SATO, NAOMICHI FUJII, KENJI NIINO, SEKIYA KOJI ...1977 Volume 30 Issue 10 Pages 852-862
Published: October 25, 1977
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS
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