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Volume 32, Issue 7
Displaying 1-7 of 7 articles from this issue
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III. COMBINATION OF AMPICILLIN AND DIBEKACINHARUE ARATANI, MASAYUKI NAKATSUKA1979 Volume 32 Issue 7 Pages 711-719
Published: July 25, 1979
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS1. Pharmacokinetics was investigated when ampicillin (ABPC)(50 mg/kg) and dibekacin (DKB)(5 mg/kg), in combination with pre-or post-treatment, were intravenously injected to the rat or rabbit.
2. The antibiotics in the samples were separated by the paper-electrophoretic technique and then concentrations were determined by the cup thin-layer plate method using Bacillus subtilis ATCC 6633 as the test organism.
3. The biological half-life of DKB was prolonged in pretreatment with ABPC and that of ABPC was shortened in pretreatment with DKB. An initial level of ABPC was elevated. Similar tendency was observed in both of the rat and rabbit.
4. Urinary excretion rates of both antibiotics in the combining group tended to decrease compared with the single administration group.
5. Bmding of ABPC to serum proteins was competitively inhibited by DKB. Binding of DKB to serum proteins increased.View full abstractDownload PDF (1077K) -
TAXONOMIC STUDIES OF THE PRODUCING MICROORGANISM AND SIMULTANWOUS PRODUCTION OF BLEOMYCIN GROUP AND TREPTOTHRICIN-LIKE ANTIBIOTICSTOSHIO OTANI, KURUMI ISHIMARU, YOSHIYUKI KAWAKAMI, HIDETO YOSHIYAMA, H ...1979 Volume 32 Issue 7 Pages 720-728
Published: July 25, 1979
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSA new antifungal antibiotic, named neo-enactin, was produced mainly in the mycelia of strain H 829-MY 10. Strain H 829-MY 10 was identified as a Streptoverticillium, determined to be nonchromogenic, and fits in the white color-series. Although Streptoverticillium olivoreticuli is known to be chromogenic, strain H 829-MY 10 is most related to that species. Thus, strain H 829-MY 10 is named as Streptoverticillium olivoreticulisubsp. neoenacticus. Besides neo-enactin, two bleomycin-group antibiotics and two streptothricin-like antibiotics were simultaneously produced by strain H 829-MY 10.View full abstractDownload PDF (3949K) -
TOYOKO OGURI, NOZOMU KOSAKAI1979 Volume 32 Issue 7 Pages 729-743
Published: July 25, 1979
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSAntibacterial activity of ticarcillin was determined in comparison with that of sulbenicillin, amoxicillin, cefuroxime, clindamycin and metronidazole against anaerobic bacteria which have been isolated from various clinical materials in this hospital.
Growth of more than 90% of Gram-negative anaerobic rod bacteria was inhibited by ticarcillin at its concentration of 100 μg/ml. Strains resistant to ticarcillin showed cross resistance against both sulbenicillin and amoxicillin.
Antibacterial activity of ticarcillin against Gram-positive anaerobic bacteria was found almost equal to sulbenicillin but slightly inferior to amoxicillin.
Cefuroxime was found most inferior among the tested six antibiotics when an inoculation level of 108/ml was utilized, but it showed similar activity to ticarcillin when they were tested with 106/ml inoculation.
Approximately 10% of Bacteroides strains was resistant to clindamycin while all the strains were sensitive to metronidazole.View full abstractDownload PDF (1578K) -
MASAKAZU ASAHI1979 Volume 32 Issue 7 Pages 744-750
Published: July 25, 1979
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSIt is impossible to accurately evaluate NK 631 as an anticancer agent from the findings only in the 7 cases; hence, the following is no more than the author's impression about the drug. However, NK 631 appeared to exert a similar anticancer effect to the currently available bleomycin.
In other words, the drug will completely cure or greatly improve the early cases of squamous cell carcinoma, and bring about a transient regression in the advanced cases. The response of malignant lymphoma to this drug varied from case to case; in any event, it is impossible to anticipate a complete cure in this malignancy by single NK 631 therapy but by multiple combination chemotherapy, e.g., BEMP therapy.
The adverse reactions to NK 631 that were observed included pulmonary fibrosis, though only in 1 case; hence, no conclusive opinion should be given herein about its pulmonary toxicity in comparison with the pulmonary toxicity of bleomycin. It remains a theme of the future statistic studies in a large number of cases. The other adverse reactions were anorexia and mild alopecia in some of the cases, which were similar to those to bleomycin. Pigmentation also occurred in one of the cases, but the author was impressed that this reaction was less likely to occur with NK 631.View full abstractDownload PDF (12339K) -
FUMIHIKO SATOH, HITOSHI SAITO, OSAMU MIZUKOSHI1979 Volume 32 Issue 7 Pages 751-755
Published: July 25, 1979
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS1. The antitumor effect of pepleomycin observed in 11 cases of malignant tumors of the head and neck was compared with that of bleomycin in similar cases, and the former appeared slightly preferable.
2 The adverse reactions to the 2 drugs were similar to each other; however, those to pepleomycin were milder.
3.Only few cases exhibiting such severe pulmonary fibrosis as emphasized in published data have been encountered in bleomycin treatment in the authors'department. However, with reference to the measurements of Pa02 in the pepleomycin-treated cases, this may be said to be an anticancer drug which is easier to use clinically.
4. Adverse reactions to pepleomycin, e.g., alopecia, malaise, and others, were less frequent and less severe than those to bleomycin. 5. It was studied by the auditory acuity test in 10 cases (excluding 1 dropout) whether any auditory anc uaitnyy doisf otrhdee r cawseosu.ld occur after pepleomycin treatment: No changes in auditory acuity were observed in any of the cases.View full abstractDownload PDF (3400K) -
YOICHI ONODA, HISAYA TSUGAMI1979 Volume 32 Issue 7 Pages 756-765
Published: July 25, 1979
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
SMIJI MATSUDA, MIKIHIKO TANNO, TAKASHI KASHIWAKURA1979 Volume 32 Issue 7 Pages 766-768
Published: July 25, 1979
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS
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