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Volume 33, Issue 12
Displaying 1-12 of 12 articles from this issue
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PATIENTS NOT RESPONDING TO OTHER CONVENTIONAL ANTIBIOTICSSATOSHI YAGUCHI, MITSUHARU OGI, KENJI YAMASHINA, TOYOJI KOBAYASHI, YAS ...1980 Volume 33 Issue 12 Pages 1259-1267
Published: December 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSCefoxitin was administered to a total of 17 patients with intractable bronchopulmonary infections who had failed to respond to other conventional antibiotics, and the following results were obtained.
(1) The clinical response, except 1 patient classified as evaluation impossible, was excellent in3 patients, good in 10 and fair in 3 with an efficacy rate of 81.3%.
(2) An improvement rate of more than70% was observed in the findings of body temperature, dyspnea, colour of sputum, WBC and CRP.
(3) There was no subjective nor objective side effects attributable to cefoxitin.
In view of the results stated above, we have concluded thatcefoxitin is a useful antibiotic for the treatment of intractable bronchopulmonary infectionsView full abstractDownload PDF (1050K) -
KOJI SHIRAMATSU, KAZUAKI SASAKI, YOSHIRO MARUYAMA, KIMINOBU UCHIZAWA, ...1980 Volume 33 Issue 12 Pages 1268-1273
Published: December 25, 1980
Released on J-STAGE: May 17, 2013
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AKIRA KAJIKI, MASAHIRO TAKAMOTO, TSUNEO ISHIBASHI1980 Volume 33 Issue 12 Pages 1274-1276
Published: December 25, 1980
Released on J-STAGE: May 17, 2013
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YOSHIKIYO TOYONAGA, YOSHIIE KUROSU, KOMEI KUMAGAI, MAKOTO HORI1980 Volume 33 Issue 12 Pages 1277-1284
Published: December 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSThe following results were obtained from the fundamental and clinical studies of cefuroxime, a new synthetic cephalosporin, in pediatric patients with purulent meningitis.
This drug was administered to 2 pediatric patients with purulent meningitis at the dose of50mg/kg, by intravenous drip infusion over30minutes and one shot intravenous injection respectively. When spinal fluid levels were determined, about15-30%of the drug concentration in blood was found to transfer to spinal fluid at acute stage.Spinal fluid levels were about4-7μg/ml.
When4pediatric patients with purulent meningitis were treated with the drug, the good results were obtained in all of them.The dose given was200-300mg/kg/day and the dosing duration was 14-22 days.
No adverse reaction was noted, nor abnormal laboratory test values were noted.View full abstractDownload PDF (1140K) -
STUDY IN THE PEDIATRIC DEPARTMENTRYOCHI FUJII, KEIKO YAMAOKA, HIROKO SANADA1980 Volume 33 Issue 12 Pages 1285-1293
Published: December 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSAntibiotic use at the Department of Pediatrics, Teikyo University Hospital was studied from 1974 to 1978, during which period a marked change was observed in the antibiotic consumption of Japan on the whole.
From the view point of net weight of antibiotics consumed, 13-lactam antibiotics have been increasing up to more than90% of antibiotic consumption and then follow macrolides and aminoglycoside substances.
Chloramphenicol which was once the top antibiotics prescribed, and tetracyclines which have not been our choice, both have become very minor antibiotics in our present prescription.
More than 90% of oral antibiotics were prescribed for outpatients and more than90%of injectable antibiotics were administered for inpatients.
Concerning oral penicillins, major three were ACPC, ABPC and AMPC for these years and as to oral CEPs most of them was CEX.
ABPC and the fixed combination of ABPC and penicillinase resistant penicillin, were the top choice among injectable penicillins and CEZ was the top among CEPs.
Concerning aminoglycoside antibiotic SM and KM were prefered as antituberculosis drug, and GM and DKB as antipseudomonas drug which took the main role inplace with CBPC and SBPC since 1976.
The type of oral drug prefered by pediatricians for prescription was also investigated and dry syrup type was found to be the most important one for pediatrics use.
In spite of a steady increase of our outpatients for these five years, there was observed a remarkable decrease in number of antibiotic prescriptions, namely from 8,223 in 1974 to 4,613 in 1978.
The reason is esteemed due to our policy to restrict possibly the needless use of oral antibioticsView full abstractDownload PDF (1595K) -
SADAKO HIRASAWA, HIROMU ABE, EIICHI BEKKI, IKUO HASHIMOTO, YASUO SAWAD ...1980 Volume 33 Issue 12 Pages 1294-1300
Published: December 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSA new antibiotic drug of cephalosporin, with marked resistance to β-lactamase, cefoperazone (CPZ) for parenteral use was used in 10patients with acute cholecystitis or cholangitis with cholelithiasis. CPZ was given by drip intravenous injection at a daily dose of1to4g. Clinical response was excellent in1case, good in7cases, fair in2cases and poor was none.Clinical adverse effect was not recognized.
And CPZ in a dose of 1g was given intravenously during the operation to 6 of those patients. Tissue specimens of different sites were taken from removed organs.The materials of A-bile and B-bile were subsequently taken at intervals.Determination of CPZ concentration was performed according to paper disk method with Micrococcus luteus ATCC 9341 strain.
CPZ concentrations in the A-bile increased quickly soon after injection, and reached high level peak at30-min.to1-hour, then they were very slow decline.CPZ was observed in the B-bile through the gallbladder wall, and reached high level concentration comparative quickly after intravenous injection. CPZ concentration in the gallbladder wall, was directly proportional to the degree of pathological changes of inflammation.
On the CPZ concentration in patients with acute cholecystitis, the concentration in A-bile, B-bile and gallbladder wall were observed extremely higher than the MIC of CPZ for Escherichia coli.
CPZ therefore will be a very useful drug when used for chemotherapy of biliary tract infection.View full abstractDownload PDF (1160K) -
IKUO HASHIMOTO, YASUO SAWADA, TAKASHI NAKAMURA, JIROH MIKAMI, SADAKO H ...1980 Volume 33 Issue 12 Pages 1301-1305
Published: December 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSA new antibiotic drug of cephalosporin, with marked resistance to β-lactamase, cefoperazone (CPZ) for parenteral use was used in 6 patients with acute peritonitis and perforated appendicitis. CPZ in a dose of 1 g was given intravenously during the operation. Tissue specimens of different sites were taken from removed organs. The materials of purulent ascites and appendix were subsequently taken at intervals. Determination of CPZ concentration was performed according to paper disk bioassay with Micrococcus luteus ATCC 9341 strain.
CPZ concentration in purulent ascites increased quickly after injection, and reached high level peak at 30 minutes to1hour, then they were very slowly declined.CPZ concentration in the infected appendix, was directly proportional to the degree of pathological changes of inflammation.
CPZ concentration in serious gangrenous appendix reached to 50.3 mcg/g at 20 minutes after intravenous injection, and increased to 54.3 mcg/g at 30 minutes, 60.3 mcg/g at 38 minutes, respectively.
On the CPZ concentration in patients with perforate appendicitis, the concentration in purulent ascites and appendix were observed higher than the MIC of CPZ for Escherichia coil and Klebsiella pneumoniae bacilli.
CPZ therefore will be a very useful drug when used for chemotherapy of acute peritonitis.View full abstractDownload PDF (768K) -
AKIRA GONDO, KOU KIMURA, YASUAKI TOKUDA1980 Volume 33 Issue 12 Pages 1306-1312
Published: December 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSCefoperazone (CPZ), a new semisynthetic cephalosporin derivative, was administered in the treatment of pyoderma. The results were shown as follows.
CPZ was given to 21 patients with pyoderma. In 21 patients, marked improvement was seen in 7, effectiveness in 10, slight improvement in 1 and ineffective in 3.
Total clinical effectiveness rate was 81.0%.
No serious side effects were observedView full abstractDownload PDF (832K) -
SHOZO KAWAMURA1980 Volume 33 Issue 12 Pages 1313-1317
Published: December 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSCefoperazone (CPZ) was administered to 23 patients of various infections in otorhinolaryngological field. These 23 cases included acute suppurative otitis media (11), acute exacerbation of chronic suppurative otitis media (11) and perichondritis of the auricle (1).
Clinical response obtained in these cases was excellent in11cases (47.8%), good in 7 cases (30.4%), fair in 5 cases (21.7%) and none of poor case. The efficacy rate was 78.3%.
Five cases of chronic suppurative otitis media and perichondritis of the auricle infected by Pseudomonas were over good effective in 4 cases.
No side effect was observed in these 23 cases.View full abstractDownload PDF (594K) -
FUSANOSUKE YAMASAKU, YASUTOSHI SUZUKI, KOSHIRO UMEMURA1980 Volume 33 Issue 12 Pages 1318-1331
Published: December 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSRibostamycin is an aminoglycoside antibiotic produced by Streptomyces ribosidificus, and extracted and isolated by NIIDA et al. 1, 2) It has been used widely clinically with its characteristic of low ototoxicity.
UMEMURA et al. studied the pharmacokinetics of this antibiotic in animals and reported that it has a similar pharmacokinetic behavior in vivo to kanamycin. 3)
In the present studies, the pharmacokinetic behavior of ribostamycin was studied in 5 healthy adult volunteers receiving different doses (0.5g, 1.0gand1.5g) by intramuscular injection, and 0.5 g by intravenous drip infusion.In addition, a similar study was conducted with11patients with varying degrees of renal dysfunction in order to study the application of ribostamycin in such patients.View full abstractDownload PDF (1492K) -
KATSUHIKO SAWATARI, SACHIKO KITAJIMA, KOICHI SOTOWA, CHIKAKO MOCHIDA, ...1980 Volume 33 Issue 12 Pages 1332-1342
Published: December 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
1980 Volume 33 Issue 12 Pages 1343-1346
Published: December 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSDownload PDF (249K)
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