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Volume 33, Issue 9
Displaying 1-13 of 13 articles from this issue
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SUSUMU NAKAZAWA, HAJIME SATO, KENJI NIINO, SHIN-ICHI NAKAZAWA, HIROYUK ...1980 Volume 33 Issue 9 Pages 865-870
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSClinical trial of cefoperazone (CPZ) for the treatment of 15 cases suffering from pertussis was performed and the results were as follows.
The method of administration, as a rule intravenous infusion was performed at 100-200 mg/kg/day.
(1) Seventeen strains of Bordetella pertussis showed under 0.006 mcg/ml of MIC. It was similar to PIPC
(2) Any effect to hepatic or renal function was not observed.
(3) Clinical response obtained in these cases was excellent in 13 cases (86.7%), good in 2 cases (13.3%) and none of poor case.View full abstractDownload PDF (624K) -
NAOICHI IWAI, AKIRA SASAKI, MITSUNOBU MIYAZU, TAMIKO OSUGA, KAZUYO INO ...1980 Volume 33 Issue 9 Pages 871-890
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSExperimental and clinical studies on cefoperazone (CPZ), a new synthetic cephalosporin, were performed in the field of pediatrics.
1) The MICs of CPZ against 26 strains of S.aureus, 21strains of E.coli, 20 strains of K.pneumoniae and 15 strains of H.influenzae which were clinically isolated were estimated and compared with those of CEZ and ABPC.Some strains were found to be high in the MIC of CPZ against S. aureus, E.coli and K.pneumoniae by original inoculation but 88% of S.aureus, 95% of E.coli, 95% of K.pneumoniae and 100% of H.influenzae were under 6.25 mcg/ml by 100 times dilution inoculation.
The MIC of CPZ against S.aureus was inferior to CEZ and superior to ABPC, and that against E. coli, K.pneumoniae and H.influenzae was superior to CEZ and ABPC.
2) The serum concentration, urinary concentration and recovery rate from urine were measured in two healthy infants and one infant in the stage of convalescence from cholangiohepatitis after a single intravenous administration of 25 mg/kg of CPZ. The mean serum concentration in the two healthy infants was 88.0mcg/ml at 30 minutes, 63.0at 1 hour, 31.4 at 2 hours, 12.2at 4 hours and 4.2at6hours;the half-life was 1.29 hours, and the recovery rate from urine was 14.5%.
3) The clinical effect of CPZ was examined in 16 cases of acute lobar pneumonia or acute bronchopneumonia, 1 case of acute bronchitis and 4 cases of acute urinary tract infections.
All of the cases responded effectively or markedly effectively.Among the causative bacteria in those cases, 2 strains of S.pneumoniae, 1 strain of S.faecalis, 1 strain of H.influenzae and 2 strains of E.coli and 1 strain of K.pneumoniae disappeared following the administration of CPZ.
The bacteriological effect against 1 strain of P.aeruginosa was unknown, but clinical effectiveness was observed in this case.
No clinical side effects were observed.Laboratory examination carried out before and after the administration revealed a rise of GOT and eosinophilia in each one case, but in both abnormality returned to normal after termination of therapy.View full abstractDownload PDF (7588K) -
HITOSHI KAMIYA, YOSHIAKI KAWAMURA, MASAKAZU INOUE, YASUO TANIMOTO, MIN ...1980 Volume 33 Issue 9 Pages 891-898
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS1.Susceptibility, concentrations in serum and spinal fluid, and clinical effect of cefoperazone (CPZ), a newly developed cephalosporin in Japan, were examined in 28 infants from 2 days to 12 years old of ages with various infections.
2.The overall clinical evaluation in 22 cases received CPZ alone was found to be markedly effective in 11 cases and effective in 6 cases;the efficacy rate was as good as85.0%.
3.The mean half-life following a single intravenous injection of 25 mg/kg to 3 infants was 80.7 minutes.
4.The side effects observed during the therapy were 2 cases of rash and 1 case of vascular pain and these symptoms improved after interruption of therapy.The side effects of CPZ seemed to be not more noticeable than other cephalosporins.View full abstractDownload PDF (2615K) -
TADAFUMI NISHIMURA, KENJI HIROMATSU, TOSHIO TAKASHIMA, KAZUO TABUKI, Y ...1980 Volume 33 Issue 9 Pages 899-909
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSThe authors have carried out the laboratory and clinical studies of cefoperazone (CPZ). The results were as fbllows:
The sensitivity was estimated by plate dilution method on 26 strains of S.aureus, E.coli and K. pneumoniae, 25 strains of P.aeruginosa, 14 strains of Salmonella sp.and 9 strains of GM resistant P.aeruginosa is olated from patient S.The distribution of sensitivity of S.aureus was 1.56-25mcg/ml and the peak of distribution was 3.13mcg/ml.The growth of 96.2% of E.coli was inhibited at concentration of less than 12.5mcg/ml.The growth of 50.0% of K.pneumoniae was in hibited at concentration of less than 6.25mcg/ml.The peak of distribution of P.aeruginosa was 12.5-25mcg/ml (GM sensitive) and 12.5mcg/ml (GM resistant). CPZ was given by drip infusion for 30 minutes at a single dose of 25mg/kg to 2 children, and by drip infusion for 60 minutes at a single dose of 46.9mg/kg to a child.The serum mean level of CPZ was 127.5±8.5mcg/ml at 30 minutes, 30.5±7.5mcg/ml at 1 hour, 235±3.5mcg/ml at 2 hours, 10.5±1.5mcg/ml at 4 hours and 6.8±2.4mcg/ml at 6 hours after administration at a single dose of 25mg/kg, respectively.The serum level was 102.0mcg/ml at 1 hour, 32mcg/ml at 2 hours,.14.5mcg/ml at 5 hours and 12.5mcg/ml at 7 hours after administration at a single dose of 46.9mg/kg.Half-life time was 92 minutes.
The mean urinary excretion rate was 32.0±7.3%in the drip infusion for 30 minutes up to 8 hours after administration.
CPZ was effective in 6 of 8 cases with pediatric bacterial infections.
No side effects were observed except for 1 case with elevation of GOT.View full abstractDownload PDF (1303K) -
YUTAKA KOBAYASHI, YOSHIRO MORIKAWA, TSUNEKAZU HARUTA, TORU FUJIWARA1980 Volume 33 Issue 9 Pages 910-915
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSClinical evaluation was made on cefoperazone (CPZ) and the following conclusions were obtained.
(1) Serum concentrations of the drug after a one-shot intravenous injection of 22.2mg/kg were 77mcg/ml (30 minutes), 50mcg/ml (1 hour) and 8.9mcg/ml (4hours) and T1/2 of serum concentration was 68.5 minutes.A 35-day-0ld female with obstructive jaundice associated with choledochal.cyst was given by a 30-minute drip infusion of 26.8mg/kg of the drug.Serum concentration was 90mcg/ml at the end of infusion, slowly declined thereafter, and was 47.5mcg/ml at 6hours.Its T1/2 was 395 minutes.A patient with pyelonephritis complicated with right hydronephrosis was similarly treated with 24.4mg/kg.T1/2 of serum concentration was not prolonged, i.e., 82.1minutes, but urinary recovery rate up to 6 hours was decreased to 15.9%.
(2) Five patients, including three with pyelonephritis (causative organism: K.pneumoniae 2 and P.aeruginosa 1) and each one patient with pneumonia (unknown) and with postoperative infection (S. faecalis), respectively, were treated with 66.7-96.8mg/kg/day of CPZ in 3 divided doses for 5-12 days either by one-shot intravenous or by 30-60-minute drip infusion.An overall efficacy rate was excellent in 3 and good in 2, and there was no failure.Causative organisms disappeared in all cases.
(3) Although one patient was excluded from the study because the diagnosis was supposed to be viral proumonia, all six patients who were given CPZ did not exhibit any adverse reactions except for mild eosinophilia in two instances.
(4) The foregoing results as well as the review of the literature clearly indicate the eHectiveness of CPZ in the treatment of bacterial infections in children.View full abstractDownload PDF (833K) -
TAKASHI OKAMOTO, KATSUAKI OOHARA, MASAO HIROSE, TEIZOU HOSODA1980 Volume 33 Issue 9 Pages 916-924
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSCefoperazone (CPZ) was given intravenously to 23 children with the following acute bacterial infections;10cases of pneumonia, 4 cases of urinary tract infection, 2cases of purulent cervical lymphadenitis, 2 cases of pertussis pneumonia, 2cases of septicemia, 1case of osteomyelitis, 1caseof perforative peritonitis and1case of bacterial meningitis.
Clinical effectiveness was obtained in20cases out of23cases and bacteriological effectiveness in 14 cases out of 17 cases.
With CPZ, the following side effects developed;transient diarrhea in1case, asymptomatic eosinophilia in 2 cases.
From the above clinical results, it is apparent that CPZ is a useful antibiotic for treating pediatric patients with various kinds of bacterial infections.View full abstractDownload PDF (1049K) -
SEIKYO FURUKAWA, TAKASHIGE OKADA, FUMIO HIRAO1980 Volume 33 Issue 9 Pages 925-930
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSCefoperazone (CPZ) was studied clinically and the following results were obtained.
The drug was administered to 21 cases of bacterial infections;respiratory tract infection (17), lymphadenitis (1), urinary tract infection (1), enterocolitis (1) and purulent meningitis (1).The daily dose was 50-125mg/kg.The drug was given by one-shot intravenous injection, 3-4times a day and the duration of administration was from 3-18 days.
The overall efficacy rate was 81.0%, i.e., excellent in 11 cases, good in 6 cases, moderate in 2 cases and poor in 2 cases.
CPZ was potent in the treatment of ampicillin-resistant Haemophilus influenzae meningitis.
One patient developed exanthema.No other serious side effects were observed.View full abstractDownload PDF (2964K) -
MASUHIDE MIYAO, YASUHIRO KURODA, HIROSHI TANAKA, MITSUO MIZUI, YOKO UY ...1980 Volume 33 Issue 9 Pages 931-934
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSIn order to evaluate effectiveness of cefoperazone (CPZ) in the treatment of, bacterial infections of children, the clinical studies were carried out.CPZ was administered by one-shot injection to 28 patients at daily dose of 50-160 (average 89.7) mg/kg in 3-4 divided dose for 2-10 (average, 5.6) days.
The overall efficacy rate in 28 cases was 92.9 %, i.e., excellent in 16 (57.1 %), good in 10 (35.7%), fair in 1 (3.6%) and poor in 1 case (3.6 %).
Temporary rise of GOT and GPT or only GOT was observed in each 1 case out of 28.cases (7.1%), but any other abnormality was not observed throughout this series.
Based on the above results, CPZ was thus considered to be a useful antibiotic in treatment of pediatric infections caused by Gram-positive cocci and Gram-negative rods.View full abstractDownload PDF (626K) -
HIROSHI MATSUDA, TETSUYA YOSHIDA, NORITAKA KAGATA, SEIJI NIINO1980 Volume 33 Issue 9 Pages 935-940
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSClinical studies on cefoperazone (CPZ), a new cephalosporin, were carried out at our department.
Seventeen children with the following bacterial infections were treated with CPZ;pneumonia (7), bronchitis (6), tonsillitis (1), sepsis (2) and purulent meningitis (1).
The dosage was 56-182 mg/kg/day, divided into4doses, and given intravenous injection.The duration of administration was from 4 to 15 days.
Clinical results were excellent in 3 cases, good in 9 cases, moderate in 3 cases, poor in1case and uncertain in1case.The overall efficacy rate was 75.0%.
No side effects were observed.View full abstractDownload PDF (733K) -
TAKASHI MOTOHIRO, TETSUHISA TAKECHI, NORIKO SOEJIMA, HIROSHI WATARI, K ...1980 Volume 33 Issue 9 Pages 941-958
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSLaboratory and clinical studies of cefoperazone (CPZ), a new semisynthetic cephalosporin, were investigated and following results were obtained.
(1) Blood level: CPZ was given intravenous dose.of, 25mg/kg and50mg/kg to each3children.In the former, the blood level of15minutes after injection was194.2mcg/ml on average and the half life was106.2minutes.In the latter, the blood level was 320.0mcg/ml pn average and half life was 102.2minutes.
(2) Urinary concentration: In the cases of the dose of 25mg/kg, 35.9%of CPZ was recovered on average from the urine within6hours after injection, and the urinary concentration reached to 2,148.6mcg/ml (0-2 hours).And in the cases of the dose of 50mg/kg, dip recovery rate in urine was 43.6%, and the urinary concentration was 3,008.3mcg/ml.
(3) Cerebrospinal fluid level: CSF level was determined in a patient with bacterial meningitis by S.pneumoniae. Ninety mg/kg of CPZ were given intravenous Injection.After 60 minutes CSF level was 3.35mcg/ml, and after 80 minutes the blood level was 192.0mcg/ml.
(4) Bacteriological evaluation: Against 164 strains isolated clinical specimens, the bacteriological evaluation on CPZ was performed in comparison with cefotaxime (CTX), cefazolin (CEZ) and piperacillin (PIPC) by inoculum size of 108 cells/ml.CPZ showed antibacterial.activity against Gram-negativebacteria almost similar to CTX and PIPC.
(5) Clinical results: CPZ was given48.3-360mg/kg/day (average146.1mg/kg/day) by intravenous route to46patients with various infection.The overall efficacy rate was 80.4%, The rate of bacteriological effectiveness was 78.9%in 19 cases.
(6) Side.effects: As side effects, diarrhea, fever, rash, urticaria, leukopenia, eosinophilia, elevation of GOT, GPT, and LDH were observed, but not seriously.View full abstractDownload PDF (2043K) -
HITOSHI HAMAGUCHI, NOBUYUKI MINAMI, ISAO TANAKA, YOSHIFUMI IWATA, REIK ...1980 Volume 33 Issue 9 Pages 959-963
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSCeftezole (CTZ) was administered to 20patients with hematopoietic malignancy complicated with infections.These patients consisted of 7cases of AML, 2 ALL, 2 AMMoL, 1APL, 1 blast crisis of CML, 2HD, and 5 NHL.In 13 cases, sites of infection were determined and causative organisms were identified.In other 7cases, sites of infection or causative organisms were unknown.In the former 13cases, pneumonia was demonstrated in 6patients, tonsillitis in 4patients, pyelonephritis in 2 patients and sepsis in 1 patient.Klebsiella was separated from 5patients as the causative organisms,.E.coli from 2 patients, E.coli and Pseudomonas aeruginosa from 1 patient, Pseudomonas cepacia from 1patient, Streptococcus viridans from 2 patients, Proteus from 1 patient and Torulopsis from 1 patient.Gram-negative rods were separated from 10 of the 13 cases (77%) as the causative organisms. CTZ was administered intravenously in dose from 4g to 16g per day combinated with other antibiotics (AMK, GM, DKB, TOB, SBPC, CBPC, LCM, ST).The response rate in 12 cases of acute leukemia and in 7 cases of malignant lymphoma was 58% and 43%, respectively.Infections occurred in 4 patients with less than 100neutrophil per mm3 did never favorably responded even with CTZ.View full abstractDownload PDF (622K) -
HIDEYUKI KANO, KENJI SAKAKIBARA, NOBUO NUKUTA, MASAO MIZOKAMI, CHIEI T ...1980 Volume 33 Issue 9 Pages 964-969
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
YUTAKA KANAZAWA, MASAHIRO ABE, KIYOYUKI MATSUMOTO1980 Volume 33 Issue 9 Pages 970-974
Published: September 25, 1980
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS
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