We examined the antibacterial activity of CMX in comparisonwith those of other CEPs, using aerobic Gram-positive cocci, aerobic Gram-negative bacilli and anaerobic bacteria, 870 strains in total, all isolated from clinical specimens, in 1979 and 1980.
Against
Streptococcus, CMX showed superior antibacterial activity than those of CFX, CMZ, CXM and CTM.
Against H. influenzae, CMX also showed superior antibacterial activity than those of CFX, CMZ, CXM, CTM and CEZ. ABPC-and PIPC-resistant strains weresensitive to CMX. CTX, CPZ and CZX also showed antibacterial activities equivalent to thatof CMX.
Against enteric bacteria,
E. coli, Klebsiella, E. cloacae, Serratia, C. freundii and Proteus, CMX showed superior antibacterial activity than those of CFX, CMZ, CXM, CTM and CEZ. Especially, against
E. coli, Klebsiella, P. mirabilis, P. rettgeri and
P. inconstans, CMX showed strong antibacterial activity.
As to non-fermentation bacteria, CMX's antibacterial activity was relatively weak except
P. putrefaciens, Alcaligenes and
Comamonas. However, it was superior than that of CEZ. In comparison with other CEPs, the strength of CMX varied according to the kinds of bacteria.
As to anaerobic bacteria, CMX showed strong antibacterial activity against Peptococcus,
Peptostreptococcus, Lactobacillus, Propionibacterium, C. perfringens, Veillonella and
Fusobacterium.However, its antibacterial activity against
Bacteroides was similar to those of other CEPs.
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