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Volume 50, Issue 11
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TOSHIO OSHIMA1997 Volume 50 Issue 11 Pages 855-861
Published: November 25, 1997
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSPredictive factors for the development of hemolytic uremic syndrome (HUS) were evaluated in 88 inpatients who suffered from enterohemorrhagic E. coli infections in the outbreak in Sakai, 1996. All in- and outpatients received oral or intravenous fosfomycin within acute phase of hemorrhagic colitis, and HUS complicated 1.4% of them. Persistence of bloody stools and dirrhea were longer in HUS patients than in non-HUS patients, but persistence of abdominal pain was not different in either group. Leukocytosis with leukocyte counts over 15,000/αl and/or elevated CRP level over 2.0mg/dl at admission, and fever and/or vomiting in the course of hemorrhagic colitis were more frequent in HUS patients than in non-HUS patients. Early intensive treatments including gamma-globlin, urinastatin, aspirin, and dipyridamole were employed in 34 high risk patients for prevention of HUS. These patients were estimated to be at risk of developing HUS because of incomplete HUS, nephropathy, elevated LDH level, thrombocytopenia, or age younger than two years old. These treatments were clinically effective.View full abstractDownload PDF (838K) -
NAGAO SHINAGAWA, SHOZO TAKEDA, SEI-ICHI OOHIRA, YOSHIKAZU YASUDA, MASA ...1997 Volume 50 Issue 11 Pages 862-870
Published: November 25, 1997
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSWe studied efficacy and safety of sulbactam/cefoperazone (SBT/CPT) in the treatment of biliary tract infections in hospitalized patients at 26 hospitals from February 1993 to March 1995.
Secondary to dropout, 273 out of 338 patients entered in the study were evaluated, 127 patients with cholecystitis, 132 patients with cholangitis, and 14 patients with liver abscesses. Of these, 93patients (34.1%) had malignancy as an underlying disease.
SBT/CPZ had an efficacy of 79.9% (218 patients; excellent: 52, good: 166), with the efficacy in patients with cholecystitis, cholangitis and liver abscess at 89.0% (113 patients), 77.3% (102 patients) and 21.4% (3 patients), respectively.
A significant difference (p<0.05) was observed in the efficacy rates of patients with (59 patients [63.4%]) and without malignancy (159 patients [88.3%]).
A total of 84 strains were isolated from bile specimens of 53 patients, and the major isolates were Escherichia coli, Pseudomonas aeruginosa and Enterococcus spp. Two or more bacterial strains 870 (16) THE JAPANESE JOURNAL OF ANTIBIOTICS 50-11 Nov. 1997 were isolated simulateously in 20 patients. Mild or moderate side effects (allergic reaction including rash etc.) were noted in 4 patients (1.18%), and laboratory abnormalities (increased GOT, etc.) were in 16 patients (4.71%) out of the total 338 patients. This study clearly demonstrated that SBT/CPZ retains its excellent clinical efficacy and safety profile, throughout its use over the past decade.View full abstractDownload PDF (857K) -
TETSURO CHIMURA, MASAHIKO ARAI, YASUHIKO ONUMA, TAKAHARE ODA, SHINNOSU ...1997 Volume 50 Issue 11 Pages 871-877
Published: November 25, 1997
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSAn investigation was made on the concentration of levofloxacin (LVFX) in cervical mucus and its clinical effects on cervicitis. The results were as follows: 1) The concentrations of orally administered LVFX in the cervical mucus of 110 subjects were determined by HPLC. During 1-4 hour after the administration the mean concentration of LVFX in the cervical mucus reached a level of 2μg/g, which was higher than the serum level. The transfer of LVFX to the cervical mucus was almost the same as that to other genital organs.
2) When LVFX was given to 102 patients at a dose of 100-200mg, t.i.d. for 4-15 days and 872 (18) THE JAPANESE JOURNAL OF ANTIBIOTICS 50-11 Nov. 1997 the efficacy was evaluated with clinical improvement, the clinical efficacy rate of LVFX was 72/102 (70.6%). Significant bacteriological effects were observed in 70/73 (95.9%), especially, the disappear-ance rate of C. trachomatis was 18/18 (100%).
3) The administration of LVFX did not cause any subjective or objective side effects and any abnormalities were not detected in the laboratory tests done in this study. These results demonstrate that LVFX can be sufficiently transferred to the cervical mucus for the treatment of cervicitis due to the infection of C. trachomatis etc.View full abstractDownload PDF (556K) -
YUMIKO SUZUKI, RIKA ISHIHARA, YUKIKO ISHII, ARISA NAKAZAWA, KOICHI DEG ...1997 Volume 50 Issue 11 Pages 878-886
Published: November 25, 1997
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSSection of Studies, Tokyo Clinical Research Center We investigated antimicrobial activity of clindamycin (CLDM) against clinically isolated Strep-tococcus pneumoniae in 1996. The results are summarized as follows: 1. The detection frequencies of macrolides (MLs)-resistance against penicillin (PC)-susceptible S. pneumoniae (PSSP) was 48.0% and those against PC-intermediate S. pneumoniae (PISP)/PC-resistant S. pneumoniae (PRSP) was 92.0%.
2. It was found that the ratio of MLs-inducible resistant strains of PSSP was 24.6% and that of PISP/PRSP was 66.0%. MLs-constitutive resistant strains of PSSP accounted for 24.0% and that of PISP/PRSP for 26.0%. MLs-constitutive resistant strains was relatively frequent in PSSP and MLs-inducible resistant strains was frequent in PISP/PRSP.
3. CLDM showed strong antimicrobial activity against MLs-inducible resistant strains. The MIC70 of CLDM against PSSP was≤0.025μg/ml and that against PISP/PRSP was 0.1μg/ml. 886 (32) THE JAPANESE JOURNAL OF ANTIBIOTICS 50-11 Nov. 1997 From these results, it was suggested that CLDM is effective against the infection of PISP/PRSP where the detection frequency of MLs-inducible resistant strains was high.
4. Antimicrobial activity of CLDM was found to be strong against MLs-inducible resistant strains, but to be weak against MLs-constitutive resistant strains. When S. pneumoniae is detected, susceptibility of the strain to CLDM should be examined.View full abstractDownload PDF (3240K) -
[in Japanese], [in Japanese]1997 Volume 50 Issue 11 Pages 887-894
Published: November 25, 1997
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS
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