The Japanese Journal of Antibiotics
Online ISSN : 2186-5477
Print ISSN : 0368-2781
ISSN-L : 0368-2781
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Volume 51, Issue 7
Displaying 1-4 of 4 articles from this issue
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  • SUSCEPTIBILITIES OF BACTERIA ISOLATED FROM PATIENTS WITH LOWER RESPIRATORY INFECTIOUS DISEASES TO ANTIBIOTICS (1996)
    HIDEO IKEMOTO, KAZUYOSHI WATANABE, TAKESHI MORI, JUN IGARI, TOYOKO OGU ...
    1998 Volume 51 Issue 7 Pages 437-474
    Published: July 25, 1998
    Released on J-STAGE: May 17, 2013
    DOIhttps://doi.org/10.11553/antibiotics1968b.51.437
    JOURNAL FREE ACCESS
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    [in Japanese]
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  • EVALUATION OF ANTIBACTERIAL ACTIVITIES OF VARIOUS ANTIBIOTICS AGAINST GLUCOSE NON-FERMENTATIVE GRAM-NEGATIVE RODS OTHER THAN Pseudomonas aeruginosa
    MASAKAZU KOUDA, JUNKO FUKUHARA, MIKA TAKEUCHI, MASAFUMI OHGAWARA, HIRO ...
    1998 Volume 51 Issue 7 Pages 475-487
    Published: July 25, 1998
    Released on J-STAGE: May 17, 2013
    DOIhttps://doi.org/10.11553/antibiotics1968b.51.475
    JOURNAL FREE ACCESS
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    MICs of piperacillin, sulbactam/cefoperazone, minocycline (MINO), gentamicin, amikacin, flomoxef, ceftazidime, cefozopran, cefsulodin and imipenem were determined, against 189 clinical isolated strains of glucose non-fermentative Gram-negative Rods (NFGNR; Acinetobacter baumannii (44), Alcaligenes faecalis (5), Alcaligenes xylosoxidans (25), Burkholderia cepacia (12), Chryseobacterium indologenes (23), Chryseobacterium meningosepticum (9), Pseudomonas fluorescens (8), Pseudomonas putida (12), Stenotrophomonas maltophilia (51)).
    Most species of these NFGNR show resistance to many antibiotics tested. Among the antibiotics used in this study, the only antibiotic effective against all species of NFGNR tested is MINO.
    The spectrums of antibacterial activities of various antibiotics determined by MICs may be useful in preliminaly test for identification of these NFGNR.
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  • IN VITRO ANTIBACTERIAL ACTIVITY OF VANCOMYCIN IN COMBINATION WITH PANIPENEM AGAINST CARBAPENEM-RESISTANT MRSA
    SUSUMU SATO, TOMISATO MIURA, YUKIKO KUDO, EMI KUDO, YOSHIHIKO SAITOH, ...
    1998 Volume 51 Issue 7 Pages 488-493
    Published: July 25, 1998
    Released on J-STAGE: May 17, 2013
    DOIhttps://doi.org/10.11553/antibiotics1968b.51.488
    JOURNAL FREE ACCESS
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    The synergistic relationship between vancomycin (VCM) and carbapenem (CRB) has been reported in antibacterial activity against CRB-resistant strains of MRSA. The purpose of this study is to investigate the antibacterial activity against CRB-resistant MRSA using VCM, panipenem (PAPM), and a combination of both. 8 strains of CRB-resistant MRSA were used to examine the effects of these antibiotics by the broth microdiluton technique.The effect of pH (pH6, 7, 8) on MIC of VCM alone was not observed in 7 out of 8 strains; MICs were between 1.0-2.0μg/ml. PAPM alone, however, showed an enhancing tendency in alkaline condition in 6 out of 8 strains. There was no influence of pH on MICs in the combination use of VCM and PAPM, showing additive effect in 1 strain and synergistic in 6 strains. Killing-curves against PAPM-resistant MRSA were examined under the following drug combinations; 1/4 MIC of VCM (0.5μg/ml) plus 1/4 MIC of PAPM (16μg/ml), and 1/4 MIC of VCM plus 1/8 MIC of PAPM (8μg/ml). The former drug combination showed synersistic effect; decrease from 1.05×105 to 6.45×104CFU/ml after 6 hours'incubation and to less than 10 CFU/ml after 24 hours. The latter drug combination showed synergistic activity (2.68×105→3.6×102CFU/ml) after 24 hours'incubation, but lost antibacterial activity after 48 hours.In conclusion, PAPM in combination with VCM showed synergistic effects on CRB-resistant MRSA.
    This combination therapy should be evaluated for the treatment of MRSA infection in patients with renal dysfunction.
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  • RESISTANCE TO MACROLIDE ANTIBIOTICS FOUND IN METHICILLIN-RESISTANT JAPANESE CLINICAL ISOLATES OF Staphylococcus aureus IN 1996
    AKIO NAKAMURA, KAZUO TANIGUCHI, KAZUE TSURUBUCHI, KOJI OHARA, TETSUO S ...
    1998 Volume 51 Issue 7 Pages 494-500
    Published: July 25, 1998
    Released on J-STAGE: May 17, 2013
    DOIhttps://doi.org/10.11553/antibiotics1968b.51.494
    JOURNAL FREE ACCESS
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    Minimum inhibitory concentrations (MICs) of erythromycin, clarithromycin, roxithromycin, oleandomycin, triacetyloleandomycin, azithromycin, josamycin and midecamycin were investigated using 200 strains of methicillin-resistant Staphylococcus aureus (MRSA) clinically isolated in Japan during 1996. The results show that the MRSAs could be classified into five groups according to MIC patterns to various macrolides and that more than 88% of the strains used were highly-resistant to all macrolides tested. It was found that 9.0% of the strains examined showed a unique MIC pattern different to that of macrolide-lincosamide-streptogramin B antibiotic resistance type. This group was found to be highly resistant to 14-membered but susceptible to 16-membered macrolides. The resistance induction by erythromycin or oleandomycin was observed to increase for clarithromycin and roxithromycin resistances in a part of strains used. On the other hand, for azithromycin, such induction was not observed.
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