The Japanese Journal of Antibiotics

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We carried out clinical and bacteriological studies on clavulanic acid/amoxicillin and amoxicillin in pediatricacute otitis media at 14general practice settings.The results are summarized as follows.
1.The major isolated or ganisms from content of middle ear effusion were Streptococcus pneumoniae31.8%, Haemophilus influenzae35.8%and Moraxella subgenus Branhamella catarrhalis1.5%.Similar resultswere observed for the major isolates organisms from content of nasopharynx Streptococcus pneumoniae31.1%,Haemophilus influenzae33.9% and Moraxella subgenusBranhamella catarrhalis19.2%.
2.42.2%of and pneumoniae isolated from middle ear effusion were drug resistant and pneumoniae (PISP, PRSP) and they were increasing year by year.
3.46.7% of and pneumoniae isolated from nasopharyngeal swab were drug resistant S. pneumoniae (PISP, PRSP) and they were increasing year by year. The incidence of drug resistant S. pneumoniae isolated from allcases and organisms were26.3% and 145%, respectively.
4.OnMIC90, antimicrobial activity of CVA/AMPC against Streptococcus pneumoniae,Haemophilus influenzae and Moraxella subgenus Branhamella catarrhalis was superior to SBTPC.
5.In the evaluation of clinical efficacy, bacteriological efficacy and utility, CVA/AMPC-treated group wassignificantly superior to AMPC-treated group.
6.Adverse reactions were observed in22%of CVA/AMPC-treated group, involving diarrhea and loose stool.

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We carried out clinical and bacteriological studies on clavulanic acid/amoxicillin and amoxicilln in pediatricsinusitis at 11 general practice settings. The results are summarized as follows.
1. The major isolated organisms from content of middle meatus were Streptococcus pneumoniae 32.2%, Haemophilus influenzae 32.0% and Moraxella subgenus Branhamella catarrhalis 25.1%. Similar results wereobserved for the major isolates from nasopharynx.
2. 62.1% of S. pneumoniae isolated were drug resistant S. pneumoniae (PISP, PRSP) and they wereincreasing year by year.
3. Drug resistant S. pneumoniae was isolated from 38.6% of all cases.
4. Regarding MIC₉₀, CVA/AMPC showed superior antimicrobial activity against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella subgenus Branhamella catarrhalis.
5. The clinical efficacy, bacteriological efficacy and utility of CVA/AMPC-treated group were 78%, 58%and 72.8%, respectively, and they were significantly superior to AMPC-treated group.
6. Adverse reactions were observed in 11.2% of CVA/AMPC group, involving diarrhea and stool loose and there was no statistical deference from those of AMPC group.

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