The Japanese Journal of Antibiotics

Show abstractHide abstract

The evaluation of seven widely-used antibiotic preparations [five cephem antibiotics; cefaclor (CCL), cefpodoxime proxetil (CPDX-PR), cefdinir (CFDN), cefditoren pivoxil (CDTR-PI), cefcapene pivoxil (CFPN-PI), one macrolide; clarithromycin (CAM) and one penem; faropenem sodium (FRPM)] for children were performed from a standpoint of water-solubilities, both as a preparation and as a component drug.
As the results, these preparations showed great differences in the water-solubilities when added 10ml water to 0.5g of each preparation. That is, their solubilities differed from about 40% (CFPN-PI) to 100% (FRPM) as a preparation, and from nearly 0% (CAM) to 100% (FRPM, CCL) as a component drug. Additionally, about a half of the insoluble residues were found to be the component drug, in the cases of three preparations (CPDX-PX, CFDN, CDTR-PI) which were solubilized at 80-90%. From these results, it was suggested that the marketed antibiotic preparations for children might be classified into three categories; i.e., [A] preparation for solution and suspension (FRPM, CCL), [B] preparation suitable to suspension (CPDX-PR, CFDN, CDTR-PI), and [C] fine granule preparation for children unsuitable to suspension (CFPN-PI, CAM).
Consequently, the names for dosage-forms of these preparations should be standardized.

View full abstract

Download PDF (676K)

Clinical effects of cefoselis(CFSL)on various infections and prevention of postoperative infections in the field of obstetrics and gynecology were investigated with a total of 100 patients of 8 facilities in Yamagata and the following results were obtained:
1. For the patients(n=70)who received the treatment with CFSL at 2g/day for 5 days to prevent postoperative infections, the treatment was effective for such infections in 68 of 69(98.6%)except one to whom the treatment was discontinued during the course.
2. For the patients with infections(n=30)who were treated with CFSL at 2-4 g/day for 5-7 days, the treatment was markedly effective in 8/30(26.7%), effective in 21/30(70%)and noteffective in 1/30(3.3%). The overall rate of efficacy was 29/30(96.7%). Based on the clinical effects for eachisolate, the bacteriological efficacy was evaluated as 29/29 and the rate of bacterial eradication for each isolate was 23/29(79.3%).
3. Laboratory test revealed liver functional abnormalities in one patient and eruption, a subjective/objective symptom caused by CFSL was noted in two patients.
These results suggest that CFSL is effective for various infections in obstetric and gynecologic field and also the prevention of postoperative infections.

View full abstract

Register with J-STAGE for free!