The Japanese Journal of Antibiotics

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The efficacy and the safety of meropenem (MEPM) were examined in obstetric and gynecological infections and the results shown below were obtained.
1. The subjects were patients with infectious diseases during a non-pregnant period (n=14), a pregnant period (n=13) and a puerperal period (n=11). After intravenous drip infusion of MEPM at 1-2g/day, the response rate was 38/39 (97.4%)(Excellent: 13/39 (33.3%), Effective: 25/39 (64.1%)).
2. The response rates in a group receiving 1g/day, a group receiving 2g/day and a group receiving a combination of both were, respectively, 25/26 (96.2%), 9/9 (100%) and 4/4 (100%).
3. In cases that did not respond to previous treatments, the response rate to MEPMwas 20/20 (100%).
4. In clinical efficacy classified by causative organisms, the rate of Excellent was 10/23 (43.5%) and the rate of Effective was 13/23 (56.5%), and the bacterial eradication rate was 21/23 (91.3%).
5. No subjective and objective adverse reactions or abnormalities in clinical laboratory tests due to administration of MEPM were observed.

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