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Volume 57 (2004)
- Issue 6 Pages 465-
- Issue 5 Pages 425-
- Issue 4 Pages 311-
- Issue 3 Pages 213-
- Issue 2 Pages 135-
- Issue 1 Pages 1-
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Volume 57, Issue 2
Displaying 1-7 of 7 articles from this issue
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2004 Volume 57 Issue 2 Pages 135-147
Published: April 25, 2004
Released on J-STAGE: May 17, 2013
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2004 Volume 57 Issue 2 Pages 149-156
Published: April 25, 2004
Released on J-STAGE: May 17, 2013
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TSUTOMU HACHIYA, KEISHI KUBO, HIDEKI YANAGISAWA2004 Volume 57 Issue 2 Pages 157-171
Published: April 25, 2004
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSWe determined the minimum inhibitory concentration (MIC) of various antimicrobial agents against 140 strains of Streptococcus pneumoniae, 131 strains of Haemophilus influemae and 178 strains of Pseudomonas aeruginosa isolated from respiratory organs in 28 affiliated hospitals in Nagano prefecture between December 2002 and February 2003.
The results of this report were as followed:
1. All 140 strains of S. pneumoniae were classified into 3 groups; penicillin-susceptible S. pneumoniae (PSSP)(47.1%), penicillin-intermediate S. pneumoniae (PISP)(43.6%) and penicillin-resistant S. pneumoniae (PRSP)(9.3%).
2. Carbapenems and glycopeptide (vancomycin) had highly potent antimicrobial activity against PISP and PRSP like PSSP. However, some of PISP or PRSP isolates were resistant to cephalosporins and a fluoroquinolone (levofloxacin).
3.All 131 strains of H. Influenzae were also classified into three groups; ampicillin sensitive H. influenzae (73.3%), β-lactamase producing ampicillin resistant H. influenzae (BLPAR)(8.4%) and β-lactamase negative ampicillin resistant H. influenzae (BLNAR)(18.3%).
4. Carbapenems and a fluoroquinolone had highly potent antimicrobial activity against BLPAR and BLNAR. However, there were clear differences among 4 carbapenems for the antimicrobial activity. Ceftriaxone (CTRX) was the most active among cepharosporins in this study.
5. The rate of P. aeruginosa isolates resistant to carbapenems, a fluoroquinolone and aminoglycosides were about 11-16%, 15% and 0.6-8%, respectively. None of the strains was resistant to all 3 antimicrobial classes, but 3 strains were resistant to combination of 2 classes.
6. The MIC50 and MIC90 values of various antibiotics against S. pneumoniae, H. influenzae and P. aeruginosa were different in all 4 regions.In conclusion, the antimicrobial surveillance programs are important for guiding empiric therapy and for focusing interventional control of antimicrobial resistance in regions and hospitals.View full abstractDownload PDF (1883K) -
Gifu Working Group of Forum on Microbial ResistanceHIROSHIGE MIKAMO, KAORI TANAKA, KUNITOMO WATANABE, HARUKI SAWAMURA, SH ...2004 Volume 57 Issue 2 Pages 172-186
Published: April 25, 2004
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSWe analyzed Streptococcus pneumoniae isolates confirmed by direct PCR in Gifu prefecture between May 2002 and August 2002. We analyzed isolates of 254 strains from 6 hospitals to determine antibiotic susceptibility, genotype of penicillin-binding protein (PBP) genes and macrolide resistant genes, and the serotypes distribution of isolates from Matsubara Otorhinolaryngology Clinic. Isolates in which abnormal PBP genes of pbp1a, pbp2x, and pbp2b were identified by PCR were classified based on PCR results as follows; (i) penicillin-susceptible (PSSP) with 3 normal PBP genes,(ii) penicillin-intermediate (PISP) with an abnormal pbp2x,(iii) PISP with an abnormal pbp2b,(iv) PISP with abnormal pbp2x and pbp2b,(v) PISP with abnormal pbp1a and pbp2x,(vi) penicillin-resistant (PRSP) with 3 abnormal PBP genes. The overall incidence of PRSP, PISP and PSSP was 121 (49%), 109 (42%) and 24 (9%), respectively, and there was a significant difference among some hospitals (p<0.05). However, there was no significant difference among the hospitals for the incidence of abnormal macrolide-resistant genes (mefA, ermB). Panipenem showed an excellent antimicrobial activity for injectable carbapenems against PRSP, following biapenem, imipenem, and meropenem. Cefditoren (CDTR) showed an excellent antimicrobial activity for oral cephalosporins against PRSP, following cefteram and cefcapene. Interestingly, there were 2 and 3 strains on MIC of CDTR for 8 and 4μg/mL, respectively The prevalent pneumococcal serotypes of isolates in Matsubara Clinic were 6 (17/55), following by 40 (8/55), 9 (6/5) and 15 (5/55). The endemic strains were observed in this study using pulsed field gel electrophoresis. These findings suggest the needs to continue the surveillance of bacterial resistance not only in the nationwide but also in the distict.View full abstractDownload PDF (1430K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...2004 Volume 57 Issue 2 Pages 187-195
Published: April 25, 2004
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESS -
JOJI SHIOTANI, KAZUMI TAKEHANA2004 Volume 57 Issue 2 Pages 196-203
Published: April 25, 2004
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSAmong methicillin resistant Staphylococcus aureus (MRSA) strains isolated from clinical specimens during 5 years period from 1998 through 2002 in Cancer Institute Hospital, Japanese Foundation for Cancer Research, a total of 100 strains, one per patient, were successively selected each year, and their sensitivity to various antibacterial agents was measured to assess changes over five years in their sensitivity to these drugs. The following results were obtained.
1. Little or no change was observed in the sensitivity to arbekacin during 5 years period. In contrast, atendency toward decreased sensitivity was observed with vancomycin and teicoplanin, with the tendency more marked with the latter agent.
2. Arbekacin, vancomycin and teicoplanin inhibited the growth of all clinical isolates in the year 2002 at 3.13, 1.56 and 12.5μg/mL, respectively.
3. The sensitivity to netilmicin tended to decrease over the years.
4. Minocycline, imipenem and ofloxacin had little or no antibacterial activity, with MIC50 of more than 12.5μg/mL throughout the years studied.
5. Ninety five percent of MRSA strains isolated during the five years were classified as coagulase type II, and enterotoxins were found to be type C in 51% and type AC in 17% of the strains studied.View full abstractDownload PDF (826K) -
2004 Volume 57 Issue 2 Pages 204-212
Published: April 25, 2004
Released on J-STAGE: May 17, 2013
JOURNAL FREE ACCESSDownload PDF (9716K)
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