The Japanese Journal of Antibiotics

ANTIMICROBIAL SUSCEPTIBILITY OF Pseudomonas aeruginosa ISOLATED FROM URINE AT ONE HOSPITAL TO MAINLY CARBAPENEM AND FLUOROQUINOLONE DRUGS

YAEKO WATANABE, YOSHIHIRO FUJIUE, SINTAROU YANO, SATOMI SHIMIZU, KUNIO ...

2006 Volume 59 Issue 2 Pages 65-71
Published: April 25, 2006
Released on J-STAGE: May 17, 2013

DOIhttps://doi.org/10.11553/antibiotics1968b.59.65

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We tested the drug susceptibility to 8 anti-pseudomonal agents of 97 strains of Pseudomonas aeruginosa isolated from urine between January 1998 and May 2004. The results were as follows.
1. Antimicrobial activity was, in order of superiority to biapenem (BIPM), meropenem (MEPM), ciprofloxacin (CPFX), imipenem (IPM), pazufloxacin (PZFX), amikacin (AMK), ceftazidime (CAZ), piperacillin (PIPC).
2. The resistance rate (intermediate +resistance) to carbapenem drugs was 10.3% for BIPM and MEPM, and 13.4% for IPM. Many of the IPM-resistant strains showed crossover resistance with BIPM and MEPM.
3. The resistance rate (intermediate +resistance) to fluoroquinolone drugs was 23.7% for CPFX and 20.6% for PZFX.
4. One strain showed simultaneous resistance to IPM =16 μg/mL, CPFX=4μg/mL, and AMK =32 μg/mL, and produced IMP-1 metallo-β-lactamase.Susc
eptibility of P. aeruginosa isolated from urine developed resistance to fluoroquinolone drugs.
It is important to promote appropriate use of antimicrobial agents and continue to survey emerging resistance in the clinical isolates.

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BACTERIA ISOLATED FROM SURGICAL INFECTIONS AND ITS SUSCEPTIBILITIES TO ANTIMICROBIAL AGENTS

SPECIAL REFERENCES TO BACTERIA ISOLATED BETWEEN APRIL 2003 AND MARCH 2004

NAGAO SHINAGAWA, KOICHI HIRATA, TADASHI KATSURAMAKI, TOHRU MIZUKUCHI, ...

2006 Volume 59 Issue 2 Pages 72-116
Published: April 25, 2006
Released on J-STAGE: May 17, 2013

DOIhttps://doi.org/10.11553/antibiotics1968b.59.72

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Tendency of isolated bacteria from infections in general surgery during the period from April 2004 to March 2005 were investigated in a multicenter study in Japan, and the following results were obtained.
In this series, 645 strains including 17 strains of Candida spp. were isolated from 226 (79.0%) of 286 patients with surgical infections. Three hundred and seventeen strains were isolated from primary infections, and 345 strains were isolated from postoperative infections. From primary infections, anaerobic Gram-positive bacteria and anaerobic Gram-negative bacteria were predominant, while aerobic Gram-positive bacteria were predominant from postoperative infections. The isolation rate of aerobic Gram-positive bacteria, such as Enterococcus spp. and Staphylococcus aureus were higher from both types of infections. Among anaerobic Grampositive bacteria, the isolation rate of Peptostreptococcus spp. was the highest from both types of infections. Among aerobic Gram-negative bacteria, Escherichia coli was the most predominantly isolated from primary infections, followed by Pseudomonas aeruginosa, Klebsiella pneumoniae and Citrobacter freundii in this order, and from postoperative infections, P.aeruginosa was the most predominantly isolated, followed by E. coli, E. cloacae, and K. pneumoniae. Among anaerobic Gram-negative bacteria, the isolation rate of Bacteroides fragilis group was the highest from both primary infections followed by Bilophila wadsworthia. While the isolation rate of B. fragilis group was also the highest from postoperative infections, the following bacteria were Bacteroides thetaiotaomicron and B. wadsworthia in this order.
In this series, we noticed no vancomycin-resistant Gram-positive cocci, but a few strains of moderately arbekacin-resistant MRSA. Carbapenem-resistant P.aeruginosa but not multidrug-resistant was seen in 13.3 per cents. Also cefazolin-resistant E. coli probably producing extended spectrum β-lactamase was seen in 7.0 per cents. We should be carefully followed up the facts that an increasing isolation rates of B. fragilis group and B. wadsworthia which were resistant to both penicillins and cephems.

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[title in Japanese]

2006 Volume 59 Issue 2 Pages 117-124
Published: April 25, 2006
Released on J-STAGE: May 17, 2013

DOIhttps://doi.org/10.11553/antibiotics1968b.59.117

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[title in Japanese]

2006 Volume 59 Issue 2 Pages 125-132
Published: April 25, 2006
Released on J-STAGE: May 17, 2013

DOIhttps://doi.org/10.11553/antibiotics1968b.59.125

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