The Japanese Journal of Antibiotics
Online ISSN : 2186-5477
Print ISSN : 0368-2781
ISSN-L : 0368-2781
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Volume 61, Issue 2
Displaying 1-4 of 4 articles from this issue
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  • Clinical investigation on target value of T>MIC in carbapenems
    HIROSHIGE MIKAMO, YUKA YAMAGISHI, KAORI TANAKA, KUNITOMO WATANABE
    2008 Volume 61 Issue 2 Pages 73-81
    Published: April 25, 2008
    Released on J-STAGE: May 17, 2013
    DOIhttps://doi.org/10.11553/antibiotics1968b.61.73
    JOURNAL FREE ACCESS
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    There have been few clinical reports on pharmacokinetics-pharmacodynamics (PK-PD) theory, although many basic or fundamental researches on appropriate use for the antimicrobials based on the PK-PD theory have been performed. We evaluated the target T>MIC values on meropenem and biapenem which have been obtained by basic researches. While we investigated whether the target T>MIC values were also useful for anaerobic infections. Clinical and bacteriological efficacies of meropenem and biapenem were about 70% in T>MIC over 25% or over 80% in T>MIC over 30%. When monomicrobial infections by anaerobes were occurred as abscesses, there have been no correlation between target T>MIC values and clinical effect. When polymicrobial infections between aerobes and anaerobes were occurred, we have achieved over 90% clinical efficacy when over 20% T>MIC values. These results supported the data by CRAIG, W. A. and DRUSANO, G. L. The regimen based on PK-PD theory would be useful in clinical practice including against anaerobic infections.
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  • Clinical examination of doripenem for infectious diseases in gynecological and associated fields
    TETSURO CHIMURA, KAZUHIKO MURAYAMA, HIROSHI OGAWA, TOSHIO HIRAYAMA, MA ...
    2008 Volume 61 Issue 2 Pages 82-86
    Published: April 25, 2008
    Released on J-STAGE: May 17, 2013
    DOIhttps://doi.org/10.11553/antibiotics1968b.61.82
    JOURNAL FREE ACCESS
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    We examined the efficacy of doripenem(DRPM), a carbapenem antimicrobial agent, against infectious diseases in gynecological and associated fields, as well as its safety. The following resultswere obtained:
    1) The subjects were 20 patients with infection in the absence of pregnancy and 4 patients with pregnancy/puerperal infection. Intravenous drip of DRPM at 0.25g×2/day was performed for 3 to 8 days. The total doses ranged from 1.5 to 4.0g.
    2) Concerning its clinical efficacy, a complete response was achieved in 4 (16.7%) of the 24 patients, and a partial response in 18 (75.0%). The response rate was 91.7% (22/24). In 6 patients who did not respond to the previous agent, the response rate was 100% (6/6).
    3) Concerning its clinical efficacy with respect to clinically isolated bacteria, a complete response was achieved in 3 (10.0%) of the 30 strains, and a partial response in 26 (86.7%). Bacteria disappeared in 29 (96.7%) of the 30 strains.
    4) There were no side effects nor abnormalities in the laboratory data related to this agent.
    These results suggest the usefulness of DRPM in the treatment of gynecological infectious diseases.
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  • [title in Japanese]
    2008 Volume 61 Issue 2 Pages 89-104
    Published: April 25, 2008
    Released on J-STAGE: May 17, 2013
    DOIhttps://doi.org/10.11553/antibiotics1968b.61.89
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    2008 Volume 61 Issue 2 Pages 105-113
    Published: April 25, 2008
    Released on J-STAGE: May 17, 2013
    DOIhttps://doi.org/10.11553/antibiotics1968b.61.105
    JOURNAL FREE ACCESS
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