A new antifungal substance, goniodomm, has been isolated from a marine dinoflagellate,
Goniodoma sp. collected in Puerto Rico. The molecular formula, C
43H
58O
11, has been established for this compound. Physical and chemical data indicate the presence of five hydroxyl groups, a lactone ring, four ether linkages and a dihydrogeranyl side chain in this molecule. Goniodomin strongly inhibits
Cryptococcus,
Trichophyton, and other fungi, but shows little or no activity against bacteria.
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