The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Volume 21 , Issue 12
Showing 1-5 articles out of 5 articles from the selected issue
  • AKIRA TAKATSUKI, SEIKICHI SUZUKI, KUNIO ANDO, GAKUZO TAMURA, KEI ARIMA
    1968 Volume 21 Issue 12 Pages 671-675
    Published: December 25, 1968
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    The production, isolation, chemical and physical characteristics and biological properties of the new antiviral antibiotics, xanthocillin X mono- and dimethylether, and methoxy-xanthocillin X dimethylether are described. They were produced by two strains of Aspergillus sp. isolated from soil samples. The active principles were extracted from the mycelium, and isolated as yellowish crystals. They were identified as derivatives of xanthocillin X by physical methods. All three were effective against Newcastle disease, vaccinia and herpes simplex viruses in plate assays, and all inhibited the growth of Bacillus subtilis.
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  • AKIRA TAKATSUKI, GAKUZO TAMURA, KEI ARIMA
    1968 Volume 21 Issue 12 Pages 676-680
    Published: December 25, 1968
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    Effects of XME, XDE and XTE (xanthocillin X mono- and dimethylether, and methoxy-xanthocillin X dimethylether) on multiplication of Newcastle disease virus (NDV) and on proliferation of chick embryo fibroblast cells (CEF) were examined. At low multiplicity, XME, XDE and XTE suppressed CPE at low concentrations. At high multiplicity, XME (10 mcg/ml) completely inhibited occurrence of CPE and syntheses of HA and infective virus, and at lower concentrations there was no difference in final yields of HA at 23 hours post infection, but a concentration dependency was found in synthesis of HA and suppression of CPE. XDE and XTE, on the other hand, did not inhibit HA synthesis completely at high concentration, but delayed the onset of HA production and partially arrested the occurrence of CPE post infection. All three antibiotics had very low toxicity against both grown and growing primary CEF. They also had no effect on free NDV particle and on viral adsorption onto CEF.
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  • AKIO NAGATA, TAKUJI ANDO, ROKURO IZUMI, HIDEO SAKAKIBARA, TERUO TAKE, ...
    1968 Volume 21 Issue 12 Pages 681-687
    Published: December 25, 1968
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    A new antibiotic, tuberactinomycin, has been isolated from fermentation broth of a streptomyces named Streptomyces griseoverticillatus var. tubei'acticus.Tuberactinomycin is a water-soluble antibiotic belonging to the basic peptide antibiotic group, and markedly stable in acid or neutral solution. Tuberactinomycin is recovered from fermentation broth by means of a cation exchange resin process. Tuberactinomycin shows low toxicity and the activity against pathogenic tubercular bacilli both in vitro and in vivo. Taxonomical study of the producing strain, the isolation and properties of the antibiotic are reported in this paper.
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  • GAKUZO TAMURA, AKIKO KATO, KUNIO ANDO, KENJIRO KODAMA, SEIKICHI SUZUKI ...
    1968 Volume 21 Issue 12 Pages 688-689
    Published: December 25, 1968
    Released: April 12, 2006
    JOURNALS FREE ACCESS
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  • KUNIO ANDO, SEIKICHI SUZUKI, KOJI SUZUKI, KENJIRO KODAMA, AKIKO KATO, ...
    1968 Volume 21 Issue 12 Pages 690-691
    Published: December 25, 1968
    Released: April 12, 2006
    JOURNALS FREE ACCESS
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