The fate of the orally effective antibiotic D-cephaloglycin and its much less active L-enantiomer has been studied in the rat. D-Cephaloglycin-
14C is metabolized by two pathways, (1) hydrolysis of the amide linkage to form D-2-phenylglycine-
14C and (2) deacetylation to form deacetyl-D-cephaloglycin-
14C. D-Cephaloglycin is absorbed from the gastro-intestinal tract at least in part as the intact antibiotic, L-Cephaloglycin-
14C is rapidly metabolized to L-2-phenylglycine-
14C and its metabolites. In contrast to the results with D-cephaloglycin-
14C, no intact L-cephaloglycin-
14C or deacetyl-L-cephaloglycin was excreted in the urine of rats.
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