The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Volume 22 , Issue 7
Showing 1-8 articles out of 8 articles from the selected issue
  • THOMAS W. MILLER, A. KATHRINE MILLER, FRANK J. WOLF, EDWARD O. STAPLEY ...
    1969 Volume 22 Issue 7 Pages 293-296
    Published: July 25, 1969
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    Seven derivatives of 6-chloro-2-quinoxalinecarboxylic acid 1, 4-dioxide were prepared. These include esters, amides and the acid hydrazide. The derivatives were tested against fifteen bacteria by agar diffusion assay and against two bacterial infections in vivo. Increased effectiveness on oral administration was observed with the carboxamide.
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  • SEIKICHI SUZUKI, TAKAO KIMURA, KUNIO ANDO, MIKIO SAWADA, GAKUZO TAMURA
    1969 Volume 22 Issue 7 Pages 297-302
    Published: July 25, 1969
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    Mycophenolic acid shows significant antitumor activity against several strains of transplantable mouse tumors, some of which were originally established as syngeneic in tumor-host realtionship. Mycophenolic acid was more effective against solid than ascitic tumors. Oral, subcutaneous or intraperitoneal administration was equally effective.
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  • SABURO AYUKAWA, MASA HAMADA, KATSUHISA KOJIRI, TOMIO TAKEUCHI, TAKESHI ...
    1969 Volume 22 Issue 7 Pages 303-308
    Published: July 25, 1969
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    A new pigment antibiotic named chrothiomycin, which inhibits the growth of some Gram-positive bacteria and the enzymic activities of oxygenases involved in catecholamine biosynthesis in vitro, was isolated from fermentation broths of Streptomyces pluricolorescens. It is obtained as blackish purple crystals, C27H31-33O13NS.
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  • A. D. ARGOUDELIS, J. H. GOATS, D. J. Mason, O. K. SEBEK
    1969 Volume 22 Issue 7 Pages 309-314
    Published: July 25, 1969
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    1'-Demethylclindamycin was produced by N-demethylation when clindamycin was added to fermentations of Streptomyces punipalus. In contrast, addition of clindamycin to fermentations of Streptomyces armentosus resulted primarily in the production of clindamycin sulfoxide. Several other species of streptomycetes as well as several species of fungi were also found to convert clindamycin to either 1'-demethylclindamycin, clindamycin sulfoxide, or a mixture of both compounds.
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  • HIROSHI YAMAKI, NOBUO TANAKA, HAMAO UMEZAWA
    1969 Volume 22 Issue 7 Pages 315-321
    Published: July 25, 1969
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    The effects of various tumor-inhibitory antibiotics on immunological responses were investigated, using serum antibody production against human gamma globulin and sheep red cells in mice, development of tuberculin hypersensitivity in guinea pigs, and skin allograft reaction in mice. The effects on antibody-forming cells in the mouse spleen were observed by JERNE'S method. Of the antibiotics examined, pluramycin significantly suppressed the immunological responses. The responses of cellular antibodies were more markedly affected than those of circulating antibodies. By the method employed, bleomycin, phenomycin, angustmycins A and C did not exhibit any significant activity of immunosuppression. The skin allograft reaction was not significantly modified by formycins A and B. Pluramycin was observed to inhibit the growth of plasmocytoma in mice.
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  • AKIKO KATO, TETSUJI SAEKI, SEIKICHI SUZUKI, KUNIO ANDO, GAKUZO TAMURA, ...
    1969 Volume 22 Issue 7 Pages 322-326
    Published: July 25, 1969
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    A new antibiotic, oryzachlorin, C26H31O8N2S2Cl(λmax 298mμ in ethanol) has been isolated from Aspergillus oryzae. It strongly inhibits the growth of many yeasts but has no effect on bacteria or filamentous fungi. It also has antiviral activity in vitro.
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  • Paul V. Demarco
    1969 Volume 22 Issue 7 Pages 327-340
    Published: July 25, 1969
    Released: April 12, 2006
    JOURNALS FREE ACCESS
    The proton magnetic resonance spectra of some erythromycin aglycones have been investigated at 100MHz in both deuteriochloroform and pyridine-d5 solvents. Utilizing information derived from pyridine solvent Δ-values (Δ= δCDCl3-δC5D5N) and spin-spin coupling constants for vicinal protons, the preferred approximate conformations of these 14-membered lactone ring systems in solution have been shown to be the same in III, IV, V and VI and to closely approximate the conformation previously derived from X-ray analysis for the aglycone ring in erythromycin A. The asymmetry at C-9 in dihydroaglycones IV, V and VI has been shown to be S in V and VI and R in IV. The utility of pyridine solvent shifts in the three-dimensional analysis of hydroxylic compounds is uniquely demonstrated in these polyhydroxy macrolides and emphasizes the potential of this technique for structure analysis.
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  • A. D. ARGOUDELIS, J. H. COATS
    1969 Volume 22 Issue 7 Pages 341-343
    Published: July 25, 1969
    Released: April 12, 2006
    JOURNALS FREE ACCESS
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