From the hydrolysate of siomycin A, an antibiotic from
Streptomyces sioyaensis, L-threonine, L-alanine, L-valine, D-cysteine and three thiazole-4- carboxylic acid derivatives were isolated. These thiazoles were identified as thiostreptine, 2-aminomethylthiazole-4-carboxylic acid and 2-(1-amino acetonyl) thiazole-4-carboxylic acid. A 4-(α-hydroxyethyl)-8-hydroxyquinaldic acid, and two unidentified C
10- and C
12-compounds were also isolated in the hydrolysate. The formation of pyruvic acid (2 moles), α-amino-n-butyric acid (less than 1 mole), propionic acid (2-3 moles) and acetaldehyde (1 mole) by the action of acid or alkali on siomycin A was demonstrated.
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