The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Volume 22, Issue 9
Displaying 1-9 of 9 articles from this issue
  • YUKIO MIYAZAKI, RIEKO YOSHIDA, TETSURO HIDAKA, SETSUO TAKEUCHI, HIROSH ...
    1969 Volume 22 Issue 9 Pages 393-398
    Published: September 25, 1969
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    Denamycin is a new antibiotic obtained from the cultured filtrate and mycelium of Streptomyces sp. No. 8756-CC2. It is purified on silica gel column chromatography followed by crystallization from organic solvents. It shows inhibitive activities against the nucleic acid syntheses in the bacterial cells and against the growth of ascites or solid form of tumor in mice. It forms yellow needles melting at 226-228°C, and has an optical rotation of [α]20D +41° in methanol. The antibiotic shows ultraviolet absorption maximum at 311 mμ (E1%1cm 520) in ethanol, and is very unstable and degraded into several compounds under the atmospheric condition and ultraviolet light.
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  • MIKLOS BODANSZKY, NISHITH C. CHATURVEDI, JAMES A. SCOZZIE
    1969 Volume 22 Issue 9 Pages 399-408
    Published: September 25, 1969
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    From acid hydrolysates of amphomycin (+) 3-anteisotridecenoic acid, (+) 4-hydroxy-anteisotridecanoic acid lactone and 4-hydroxy-isododecanoic acid lactone were isolated. While the unsaturated acid is a genuine building component of the antibiotic, the lactones are formed from unsaturated acids during hydrolysis.
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  • LATERIOMYCINS A AND B, NEW ANTITUMOR AND ANTIBACTERIAL ANTIBIOTICS PRODUCED BY STREPTOMYCES GRISEORUBER, STRAIN NO. 71070
    EIJI HIGASHIDE, TORU HASEGAWA, MOTOO SHIBATA
    1969 Volume 22 Issue 9 Pages 409-418
    Published: September 25, 1969
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    A strain of Streptomyces (No. 71070) was isolated from a soil sample collected in Mexico. Taxonomic investigations led to its identity as a strain of Streptomyces griseoruber YAMAGUCHI and SABURI, 1955. From the mycelium of S. griseoruber strain No. 71070, two antibiotics were obtained in crystalline form and were named lateriomycins A and B, respectively. These antibiotics were especially active against Gram-positive bacteria and Yoshida sarcoma. Moreover, they are pH-indicator antibiotics changing from orange yellow in acidic solution to purple in alkaline solution. Comparison of the chemical and biological characteristics of lateriomycins A and B with known antibiotics indicated that they are new antibiotics.
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  • STUDIES ON ANTIVIRAL AND ANTITUMOR ANTIBIOTICS. XXI
    AKIKO KATO, KUNIO ANDO, TAKAO KIMURA, GAKUZO TAMURA, KEI ARIMA
    1969 Volume 22 Issue 9 Pages 419-422
    Published: September 25, 1969
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    A new antiviral substance, paecilomycerol (M. W. 428, C27H40O4) has been isolated from the acetone extract of the mycelium of Paecilomyces elegans.It is steroidal and has no antibacterial or antifungal activity, but does have antiviral activity as measured by plaque inhibition assay.
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  • THE COMPOSITION AND DEGRADATION PRODUCTS OF SIOMYCIN A
    MITSUO EBATA, KUNIKO MIYAZAKI, HIDEO OTSUKA
    1969 Volume 22 Issue 9 Pages 423-433
    Published: September 25, 1969
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    From the hydrolysate of siomycin A, an antibiotic from Streptomyces sioyaensis, L-threonine, L-alanine, L-valine, D-cysteine and three thiazole-4- carboxylic acid derivatives were isolated. These thiazoles were identified as thiostreptine, 2-aminomethylthiazole-4-carboxylic acid and 2-(1-amino acetonyl) thiazole-4-carboxylic acid. A 4-(α-hydroxyethyl)-8-hydroxyquinaldic acid, and two unidentified C10- and C12-compounds were also isolated in the hydrolysate. The formation of pyruvic acid (2 moles), α-amino-n-butyric acid (less than 1 mole), propionic acid (2-3 moles) and acetaldehyde (1 mole) by the action of acid or alkali on siomycin A was demonstrated.
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  • STRUCTURAL FEATURES OF SIOMYCIN A
    KUNIKO MIYAZAKI, MHIONOGI EBATA, HIDEO OTSUKA
    1969 Volume 22 Issue 9 Pages 434-441
    Published: September 25, 1969
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    The sequence of siomycin A was determined from the seventeen fragments of the modified antibiotic, although a complete structural formula is still not available. Siomycin contains eleven constituents, two of which are still unidentified. In the determination of the sequence, the reduced-, oxidized-, ammonia treated-siomycin A, partial acidic hydrolysis was used to provide water soluble fragments. Sanger's (DNFB) method was applied to the fragments to obtain sequence information. The structure surrounding the dehydroalanine moiety, the properties of the sulfhydryl group and the lactone ring were also investigated.
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  • STUDIES ON ANTIVIRAL AND ANTITUMOR ANTIBIOTICS. XIX
    AKIRA TAKATSUKI, ISAMU YAMAGUCHI, GAKUZO TAMURA, TOMOMASA MISATO, KEI ...
    1969 Volume 22 Issue 9 Pages 442-445
    Published: September 25, 1969
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
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  • HIDEO SUZUKI, KAZUO NAGAI, HIROSHI YAMAKI, NOBUO TANAKA, HAMAO UMEZAWA
    1969 Volume 22 Issue 9 Pages 446-448
    Published: September 25, 1969
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
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  • YUKIO KIMURA, EMIKO MURAI, MICHIKO FUJISAWA, TSURU TATSUKI, FUMIKO NOB ...
    1969 Volume 22 Issue 9 Pages 449-450
    Published: September 25, 1969
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    Download PDF (246K)
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