-
LESTER DOLAK
1973 Volume 26 Issue 3 Pages
121-125
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
The complete structure of RP 18, 631, a new chlorine-containing antibiotic related to novobiocin, has been determined using a combination of degrative and nuclear magnetic resonance techniques. Of particular interest is the long-range couplings observed in the pyrrole ring present in the molecule.
View full abstract
-
ASTRID REX, LUIS ARRIETA
1973 Volume 26 Issue 3 Pages
126-130
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
A soil isolate, designated
Streptomyces melanosporofaciens strain Chilea, differentiated from the type strain
Streptomyces melanosporofaciens ISP 5318 mainly by its compact spirals, positive sucrose utilization and different pattern of antibiotics, was found to produce a new antibiotic proposed as chilaphylin. Chilaphylin is a neutral, probably aliphatic compound, active
in vitro against Gram-positive bacteria including
Mycobacterium, and different from melanosporin and elaiophylin, the main antibiotics produced by the type strain ISP 5318.
View full abstract
-
II. SEPARATION AND CHARACTERIZATION OF CELESTOSAMINIDE ANTIBIOTICS BY GAS CHROMATOGRAPHY-MASS SPECTROSCOPY
T. F. BRODASKY, A. D. ARGOUDELIS
1973 Volume 26 Issue 3 Pages
131-134
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
The streptomycete
S. caelestis produces a number of antibiotics related to celesticetin (celestosaminides). GC of TMS-derivatized celestosaminides indicates the type of acid moiety present in the antibiotic (aromatic or alkyl) while GS-MS data lead to the molecular weight and other specific structural features. The six celesticetins described here provide data which can be applied to the characterization of new celestosaminides.
View full abstract
-
J. KONECNY, E. FELBER, J. GRUNER
1973 Volume 26 Issue 3 Pages
135-141
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
The decomposion rates of cephalosporin C in aqueous buffers and in fermentation broth at 25°C were determined by high pressure liquid chromatography and were found to obey the rate law -
dC/
dt=[Q.27 (H
+) + 0.005 + 500 (OH
-)]Cmole.l
-1.h
-1. In the acidity range from pH 3 to 7 the principal reaction is the slow attack of water on the nucleus. In alkaline and in strongly acidic solutions hydrolysis of the acetyl side chain is sufficiently fast relative to the base or acid catalyzed destruction of the nucleus to produce desacetyl cephalosporin C or its lactone in appreciable yields. In a typical fermentation non-enzymatic hydrolysis destroys about 15 % of the product.
View full abstract
-
A. D. ARGOUDELIS, T. E. EBLE, J. A. Fox, D. J. MASON
1973 Volume 26 Issue 3 Pages
142-145
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
The bioorigin of the methyl groups of 4'-depropyl-4'-ethyllincomycin has been studied. Using radioactive techniques it was determined that in addition to the -SCH
3 and NCH
3 groups, the CCH
3 present in the amino acid moiety is derived from C
1 donors. These results are identical to the findings on the origin of the methyl groups of lincomycin, the main antibiotic produced by
Streptomyces lincolnensis.
View full abstract
-
STRUCTURE-ACTIVITY RELATIONSHIPS OF α-SULFOPENICILLINS1)
SHIRO MORIMOTO, HIROAKI NOMURA, TAKESHI FUGONO, ISAO MINAMI, TOSHIHIRO ...
1973 Volume 26 Issue 3 Pages
146-152
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
Structure-activity relationships were examined for a number of α-sulfopenicillins and related compounds. Among the α-sulfopenicillins tested, the α-thienyl and α-(
p-aminophenyl) homologues showed the greatest activity against
Pseudomonas aeruginosa, and broad spectra comparable to that of α-sulfobenzylpenicillin (
1). With the exception of these two homologues, any modification in position or structure of the α-sulfo or α-phenyl group of
1, diminished activity. Relationships between antipseudomonal or antistaphylococcal activity and a negative charge in the acyl side chain are discussed.
View full abstract
-
HAROLD C. NEU, ELAINE B. WINSHELL
1973 Volume 26 Issue 3 Pages
153-156
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
The antibacterial spectrum of cephanone, a 3-heterocyclic thiomethyl cephalosporin derivative, is similar to that of cephalothin and cephalexin. Cephanone is less active against gram-positive organisms but is more active against
Escherichia coli than cephalothin. Activity against
Klebsiella, Proteus mirabilis and
Salmonella is similar to cephalothin. Some
Enterobacter strains are
?? susceptible to 8 μg/ml or less. Cephanone is relatively resistant to hydrolysis by gram-negative beta-lactamases. It is not a competitive inhibitor of the hydrolysis of penicillins by beta-lactamases.
View full abstract
-
TADASHI ARAI, YUZURU MIKAMI, KAZUTAKA FUKUSHIMA, TAKEHIKO UTSUMI, KATS ...
1973 Volume 26 Issue 3 Pages
157-161
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
A new antibiotic, leucinostatin, was isolated from the culture filtrate of
Penicillium lilacinum. The antibiotic was obtained in the form of white prisms, decomposing at 131-136°C, and showing optical rotation [α]
22D+644° (
c 0.5, methanol). The ultraviolet absorption spectrum showed only an inflection at 220 nm in methanol. The antibiotic gave a positive reaction to biuret and negative to ninhydrin. Upon hydrolysis, it gave a positive reaction to ninhydrin, yielded leucine predominantly, and the peptide nature of the antibiotic was assumed. Leucinostatin was found to be active against some gram-positive bacteria and a wide range of fungi. It was also cytotoxic to HeLa cell culture and showed some inhibitory effect on EHRLICH subcutaneous solid tumor. The LD
50 by intraperitoneal injection in mice was calculated to be 1.6 mg/kg. The antibiotic manifested a significant hypotensive effect on rabbit blood pressure without affecting epinephrine and acetylcholine responses.
View full abstract
-
TOMIO TAKEUCHI, KEIJI OGAWA, HIRONOBU IINUMA, HIROYUKI SUDA, KATSUKO U ...
1973 Volume 26 Issue 3 Pages
162-167
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
Cultured broths were screened by measuring the inhibition of monoamine oxidase. Using serotonin as the substrate, two active agents were isolated from
Actinomycetes and shown to be pimprinine and
trans-cinnamic acid amide, and a compound isolated from a mushroom was identified to be harman. Using benzylamine as the substrate, an inhibitor was isolated from a
Streptomyces and shown to be phenethylamine.
View full abstract
-
TAKASHI TSURUOKA, TAKASHI SHOMURA, YASUAKI OGAWA, NORIO EZAKI, HLROSHI ...
1973 Volume 26 Issue 3 Pages
168-174
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
Three components, SF-973 A, B, and C were obtained from a
Streptomyces olivaceus SF-973. SF-973 B catalyzed the converison of inactive SF-973 C (dihydroabikoviromycin) to bioactive SF-973 A (abikoviromycin). Purification of SF-973 B was conducted by sequential chromatographies on columns of DEAE-cellulose, Sephadex G-75, and Sephadex G-100. The enzyme SF-973 B was most active at around pH 7 and 40-45°C in temperature range. The molecular weight was about 36, 000. SF-973 B showed oxidoreductase activity and was named dihydroabikoviromycin dehydrogenase.
View full abstract
-
KAZUTAKA FUKUSHIMA, KATSUKIYO YAZAWA, TADASHI ARAI
1973 Volume 26 Issue 3 Pages
175-176
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
-
A CHEMICAL APPROACH TO IDENTIFICATION OF THE MICROBIAL METABOLITE
R. W. RICKARDS, K. L. PERLMAN, D. PERLMAN
1973 Volume 26 Issue 3 Pages
177-178
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
-
DAVID WILLNER, VIOLET Z. ROSSOMANO, VILMARS SPRANCMANIS
1973 Volume 26 Issue 3 Pages
179-180
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
-
TOJU HATA, IWAO UMEZAWA, YUZURU IWAI, MLCHIKO KATAGIRI, JUICHI AWAYA, ...
1973 Volume 26 Issue 3 Pages
181-183
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
-
KAZIMIERZ KAMINSKI, TERESA SOKOLOWSKA
1973 Volume 26 Issue 3 Pages
184-185
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
-
YASUAKI OGAWA, TAKASHI TSURUOKA, TAKASHI SHOMURA, HIROSHI WATANABE, SH ...
1973 Volume 26 Issue 3 Pages
186-188
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS
-
HAMAO UMEZAWA, TOMIO TAKEUCHI, KOICHI MIYANO, TAICHI KOSHIGOE, HIROAKI ...
1973 Volume 26 Issue 3 Pages
189
Published: March 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
FREE ACCESS