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I. ACETYL DERIVATIVES OF MYCOBACILLIN
P.C. BANERJEE, S.K. BOSE
1973 Volume 26 Issue 5 Pages
257-260
Published: May 25, 1973
Released on J-STAGE: April 12, 2006
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Di- and triacetyl derivatives of mycobacillin, a cyclic peptide, have been prepared. Acetylation lowers its antifungal activity, the inhibitory concentration (μg/ml) for the diand triacetyl derivatives being 35-40 and 40-45 respectively as against 15-20 for mycobacillin; but acetylation gives complete protection against serum inactivation of the antibiotic whose inhibitory concentration is increased tenfold in its presence.
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L-(N5-PHOSPHONO)METHIONINE-S-SULFOXIMINYL-L-ALANYL-L-ALANINE
DAVID L. PRUESS, JAMES P. SCANNELL, HELEN A. Ax, MARTHA KELLETT, FLORE ...
1973 Volume 26 Issue 5 Pages
261-266
Published: May 25, 1973
Released on J-STAGE: April 12, 2006
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A new antibiotic was isolated from the fermentation broth of an unclassified species of
Streptomyces. The antibiotic activity against
Serratia sp. and
Bacillus subtilis, grown in a chemically defined minimal medium, was reversed by the addition of L-glutamine to the medium. Physical chemical characterization of the antibiotic and of the chemical and enzymatic degradation products revealed the structure to be L-(N
5-phosphono)methionine-S-sulfoximinyl-L-alanyl-L-alanine.
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MECHANISM OF ACTION OF BIHOROMYCIN, A NEW ANTIBIOTIC
ISAMU YAMAGUCHI, KENG-TANG HUANG, TOMOMASA MISATO
1973 Volume 26 Issue 5 Pages
267-271
Published: May 25, 1973
Released on J-STAGE: April 12, 2006
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Effects of bihoromycin on the respiration, protein and nucleic acid syntheses of
Piricularia oryzae was investigated, and a marked inhibition of nucleic acid synthesis was observed. Further experiment using
Bacillus subtilis revealed that DNA synthesis was more profoundly affected than RNA synthesis by the antibiotic. When leaves of pinto-bean and tobacco were treated with bihoromycin, it was found that the former plant was highly sensitive to the antibiotic.
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JAMES C. FRENCH, Q. R. BARTZ, H. W. DION
1973 Volume 26 Issue 5 Pages
272-283
Published: May 25, 1973
Released on J-STAGE: April 12, 2006
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The isolation and characterization of myomycin, a new broad spectrum antibiotic, are described. The isolation of
myo-inositol, L-β-lysine and 3-amino-3-deoxy-D-mannose from hydrolyzates of myomycin established it to be an unusual member of the basic, water soluble family of cyclitol antibiotics.
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N5-HYDROXY-L-ARGININE, A NEW NATURALLY OCCURRING AMINO ACID1)
HUBERT MAEHR, JOHN F. BLOUNT, DAVID L. PRUESS, LINDA YARMCHUK, MARTHA ...
1973 Volume 26 Issue 5 Pages
284-288
Published: May 25, 1973
Released on J-STAGE: April 12, 2006
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A new crystalline amino acid was isolated from the fermentation broth of a
Bacillus species and identified as N
5-hydroxy-L-arginine. This compound possesses antimicrobial activity against several microorganisms, including
Escherichia coli, which is reversed by L-arginine and related compounds.
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D. PERLMAN, S. OTANI, K. L. PERLMAN, J. E. WALKER
1973 Volume 26 Issue 5 Pages
289-296
Published: May 25, 1973
Released on J-STAGE: April 12, 2006
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D, L-3-Hydroxy-4-methylkynurenine was prepared from 3-methoxy-4-methylanthranilic acid and found to be a competitive precursor with L-tryptophan in the biosynthesis of actinomycin D by
Streptomyces antibioticus (ATCC 14888).
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CONFIGURATIONAL AND POSITIONAL ISOMERS OF BB-K8
TAKAYUKI NAITO, SUSUMU NAKAGAWA, YOSHIO ABE, SOICHIRO TODA, KEI-ICHI F ...
1973 Volume 26 Issue 5 Pages
297-301
Published: May 25, 1973
Released on J-STAGE: April 12, 2006
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BB-K8 (
1) is a new semisynthetic derivative of kanamycin acylated with L(-)-Υ-ammo-α-hydroxybutyric acid (L-HABA) at the C-l amino group of the 2-deoxystreptamine moiety. The chemistry
1) and antimicrobial activity
1, 2)) of BB-K8 have been reported. The present paper describes the two configurational isomers of BB-K8, which bear the DL- and D-HABA residue at the C-l amino group of kanamycin A, as well as the three positional isomers of BB-K8, which are acylated with L-HABA at the C-3, C-6' and C-3" amino groups of kanamycin A.
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JUN'ICHI SHOJI
1973 Volume 26 Issue 5 Pages
302-303
Published: May 25, 1973
Released on J-STAGE: April 12, 2006
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SUMIO UMEZAWA, DAISHIRO IKEDA, TSUTOMU TSUCHIYA, HAMAO UMEZAWA
1973 Volume 26 Issue 5 Pages
304-306
Published: May 25, 1973
Released on J-STAGE: April 12, 2006
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DAISHIRO IKEDA, TSUTOMU TSUCHIYA, SUMIO UMEZAWA, HAMAO UMEZAWA, MASA H ...
1973 Volume 26 Issue 5 Pages
307-309
Published: May 25, 1973
Released on J-STAGE: April 12, 2006
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ISAMU WATANABE, TSUTOMU TSUCHIYA, SUMIO UMEZAWA, HAMAO UMEZAWA
1973 Volume 26 Issue 5 Pages
310-312
Published: May 25, 1973
Released on J-STAGE: April 12, 2006
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PETER P. K. Ho, RIDHARD D. TOWNER, JOSEPH M. INDELICATO, WILLIAM J. WI ...
1973 Volume 26 Issue 5 Pages
313-314
Published: May 25, 1973
Released on J-STAGE: April 12, 2006
JOURNAL
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