In a previous paper
1) we reported that
Bacillus circulans, strain No. YQW-B6, produced a complex of aminoglycoside antibiotics designated Bu-1709, of which the two major components, A
1 and A
2, were identified as butirosins A and B
2). Two additional components, E
1 and E
2, have now been isolated and characterized. They have antibacterial spectra similar to the butirosins but with substantially less intrinsic activity. Bu-1709 E
1 and E
2 contain the paromamine moiety in place of the neamine moiety of the butirosins.
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