Cefoxitin, a semi-synthetic derivative of cephamycin C, is an analogue of cephalo-thin, and the two compounds were found to have many properties in common. A total of 232 strains of bacteria, representing 13 genera, isolated recently from clinical material, have been tested for sensitivity to both antibiotics. Against Gram-positive organisms, cephalothin was at least 8 times more active than cefoxitin, but against sensitive Gram-negative strains the activities of the two compounds were similar. Cefoxitin was active against a higher proportion of
Bacteroides fragilis, Enterobacter spp. and Klebsiella spp. than was cephalothin, and was effective against 11 out of 12 indole-producing
Proteus strains tested, all but one of which were resistant to cephalothin. Cefoxitin was remarkably stable in the presence of organisms which produce β-lactamase. Thus, on microbiological grounds, cefoxitin represents a significant advance over presently avail-able conventional cephalosporins.
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