The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Volume 27, Issue 10
Displaying 1-12 of 12 articles from this issue
  • KATSUMI KAKINUMA, KENNETH L. RINEHART, Jr.
    1974 Volume 27 Issue 10 Pages 733-737
    Published: 1974
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    A new metabolite, tryptophan-dehydrobutyrine diketopiperazine (TDD) was isolated from Streptomyces spectabilis, the organism producing the streptovaricin antibiotics.
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  • A. D. ARGOUDELIS, J. H. COATS, L. E. JOHNSON
    1974 Volume 27 Issue 10 Pages 738-743
    Published: 1974
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    Addition of aromatic acids to the culture medium of Streptomyces caelestis results in the production of antibiotics different from the celestosaminides normally produced by the organism. The new antibiotic produced when 4-aminosalicylic acid was added to the culture medium was isolated and characterized as desalicetin 2'-(4-aminosalicylate). Although biological evaluation of this antibiotic is not complete, its in vitro antibacterial spectrum is identical to that of celesticetin.
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  • ISOLATION AND STRUCTURE DETERMINATION OF FOUR HOMOLOGS OF LASALOCID A
    J. W. WESTLEY, W. BENZ, J. DONAHUE, R. H. EVANS, Jr., C. G. SCOTT, A. ...
    1974 Volume 27 Issue 10 Pages 744-753
    Published: 1974
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    Four isomeric homologs of lasalocid A have been isolated from cultures of Streptomyces lasaliensis. The homologs each arise by replacement of one of the four propionate derived methyls in lasalocid A by an ethyl group, which results in each homolog molecule containing four C-ethyls.
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  • 1-(S)-HYDROXY-2-(S, S)-VALYLAMIDO-CYCLOBUTANE-1-ACETIC ACID
    DAVID L. PRUESS, JAMES P. SCANNELL, JOHN F. BLOUNT, HELEN A. AX, MARTH ...
    1974 Volume 27 Issue 10 Pages 754-759
    Published: 1974
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    1-(S)-Hydroxy-2-(S, S)-valylamido-cyclobutane-l-acetic acid was isolated from a fermentation broth of an unidentified Streptomyces species X-1092. The structure was determined by single crystal X-ray diffraction analysis of the p-bromophenylcarbamyl derivative. The substance inhibits the growth of gram-positive microorganisms in a chemically defined medium but growth inhibition is partially reversed by L-cysteine.
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  • JAMES JIU, SETH MIZUBA
    1974 Volume 27 Issue 10 Pages 760-765
    Published: 1974
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    Two metabolites, SC-28762 and SC-28763, were produced by Spicaria ditaricata NRRL 5771. The production, the isolation and purification, and the physicochemical properties of the metabolites are described. SC-28762 is 3, 3'-di-(methoxycarbonylmethyl)-3, 3', 4, 4'-tetrahydro-9, 9', 10, 10'-tetrahydroxy-7, 7'-dimethoxy-1, 1'-dioxo-8, 8'-bi-1Hnaphtho[2, 3-c]pyran (viriditoxin). SC-28763 is 3-(2-oxopropyl), 3'-methoxycarbonyimethyl-3, 3', 4, 4'-tetrahydro-9, 9', 10, 10', -tetrahydroxy-7, 7'-dimethoxy-1, 1'-dioxo-8, 8'-bi-IHnaphtho[2, 3-c]pyran. SC-28763 exhibits good antimicrobial activities against anaerobic microorganisms.
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  • MIKIO KIKUCHI, MASAKI SHOJI, NAKAO ISHIDA
    1974 Volume 27 Issue 10 Pages 766-774
    Published: 1974
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    Streptomyces carzinostaticus produces the antitumor protein, NCS, and at the same time a related protein which antagonizes the antimicrobial effect of NCS. This has been designated pre-neocarzinostatin (pre-NCS). The physicochemical properties of pre-NCS are very close to those of NCS, except for a difference in isoelectric point. Production of pre-NCS in the culture filtrate precedes production of NCS. Pre-NCS has no antimicrobial and antitumor effect but antagonizes NCS activity.
    Pre-NCS, when given 2 hours prior to NCS, markedly diminishes the NCS-induced inhibition of Sarcina lutea growth and DNA synthesis in HeLa cells. However, the antagonistic action of pre-NCS is lost when pre-NCS is washed out from HeLa cell culture after 2 hours incubation. When pre-NCS was given intraperitoneally to mice bearing Sarcoma 180 ascites tumor, subsequent treatment with NCS failed to inhibit the tumor growth. On the other hand, the acute toxicity of NCS given intravenously was not abolished by preceding intravenous injection of pre-NCS.
    The acute toxicity of pre-NCS by intravenous injection was greater than 100mg/kg in mice.
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  • ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES
    KIMIO MIZUNO, MASATOSHI TSUJINO, MASAKI TAKADA, MITSUO HAYASHI, KIYOO ...
    1974 Volume 27 Issue 10 Pages 775-782
    Published: 1974
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    Bredinin, C9H13N3O6, is, a novel imidazole nucleoside with an immunosbppressive activity. It was isolated from the culture filtrate of Eupenicillium brefeldianum M-2166 by means of ion-exchange or partition chromatography. Bredinin shows selective cytotoxicity against L5178Y cells derived from malignant lymphoma of the mouse. As an immunosuppressant, it has favorable characteristics, namely, a potent activity, low acute toxicity, and a slight effect on a decrease of peripheral leukocytes. Bredinin inhibits the growth of vaccinia virus but not that of bacteria or fungi except for Candida albicans in vitro.
    Slight prolongation in the survival period of mice inoculated with lymphatic leukemia L1210 was observed by intraperitoneal injection of bredinin, however, it was not effective on P388 leukemia or EHRLICH ascites tumor.
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  • INHIBITION OF RIBOSOMAL PEPTIDYL TRANSFERASE BY HIKIZIMYCIN, A NUCLEOSIDE ANTIBIOTIC
    KENJI UCHIDA, HEINZ WOLF
    1974 Volume 27 Issue 10 Pages 783-787
    Published: 1974
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    The nucleoside antibiotic hikizimycin was found to inhibit protein biosynthesis in intact cells of Pseudomonas syringiae and the poly U-directed polyphenylalanine biosynthesis in a cell-free system of E. coli. The antibiotic did not affect the transfer of phenylalanine to tRNA or the attachment of phenylalanyl-tRNA to the ribosome-poly U complex. Hikizimycin acts as a marked inhibitor in the puromycin reaction.
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  • SHIGEO YAMADA, KAZUO WAKABAYASHI
    1974 Volume 27 Issue 10 Pages 788-792
    Published: 1974
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    The administration of the macrolide antibiotics, oleandomycin, spiramycin anderythromycin, caused marked depressor effect and increased histamine content inthe blood. Histamine in the blood was measured by colorimetry, fluorometry andbioassay. As method of measurement of minute quantities of histamine, fluorometryand bioassay were superior, and the technic of fluorometry was most simple.
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  • I. ISOLATION, PHYSICOCHEMICAL AND ANTIBACTERIAL PROPERTIES
    RYO OKACHI, ISAO KAWAMOTO, SEIGO TAKASAWA, MITSUYOSHI YAMAMOTO, SEIJI ...
    1974 Volume 27 Issue 10 Pages 793-800
    Published: 1974
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
    A new aminoglycoside antibiotic XK-62-2 (Sagamicin) produced by Micromonospora sagamiensis var. nonreducans nov. sp. MK 62 was isolated from its fermentation beer by use of a cationic exchange resin and silica-gel column chromatography. The purified antibiotic showed a close similarity to gentamicin C complex in physical, chemical, and antimicrobial properties, but a significant difference from gentamicin in its more remarkable activity against some Pseudomonas aeruginosa strains resistant to gentamicin C1a.
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  • MITUO KOENUMA, HARUYASU KINASHI, NOBORU OTAKE
    1974 Volume 27 Issue 10 Pages 801-804
    Published: 1974
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
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  • D. G. STRAUSS
    1974 Volume 27 Issue 10 Pages 805-808
    Published: 1974
    Released on J-STAGE: April 12, 2006
    JOURNAL FREE ACCESS
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