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PRODUCTION, ISOLATION AND CHARACTERIZATION
ISAO KAWAMOTO, RYO OKACHI, HIROMASA KATO, SHIGERU YAMAMOTO, ITARU TAKA ...
1974 Volume 27 Issue 7 Pages
493-501
Published: 1974
Released on J-STAGE: April 12, 2006
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An antibiotic XK-41 complex consisting of five components (A
1, A
2, B
1 B
2, and C) produced by a new species named
Micromonospora inositola MK-41 was isolated. The components, A
1, A
2, B
1 and C, were found to be macrolide-type antibiotics similar to megalomicins, while one component XK-41-B
2 was considered to be a new antibiotic probably belonging to megalomicin-group antibiotic. Erythronolide B was also found to be produced as a byproduct by this
Micromonospora sp.
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SEIGO TAKASAWA, ISAO KAWAMOTO, RYO OKACHI, YOZO MACHIDA, TAKASHI NARA
1974 Volume 27 Issue 7 Pages
502-506
Published: 1974
Released on J-STAGE: April 12, 2006
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A new antibiotic XK-46 is produced optimally at 46°C by a thermophilic
Streptomyces sp. MK-46. This antibiotic is a color indicator, red in acidic and blue in alkaline solutions, soluble in organic solvents and slightly soluble in water. XK-46 is active against Gram-positive bacteria and
Proteus vulgaris, and strongly inhibits tyrosine hydroxylase activity.
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MASAHITO YAMAGUCHI, SUSUMU MITSUHASHI, FUJIO KOBAYASHI, HIROSHI ZENDA
1974 Volume 27 Issue 7 Pages
507-515
Published: 1974
Released on J-STAGE: April 12, 2006
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We have found in our stock cultures of clinical origin
Providencia strains that were resistant to various aminoglycoside antibiotics including lividomycin and the gentamicin C complex but sensitive to kanamycin A and a new kanamycin A derivative, BB-K8. The substrate profile of inactivation of aminoglycosides combined with structural studies of the inactivated product of 3'-deoxyparomamine, indicate that aminoglycosides were inactivated by acetylation of the amino group at the 2'-C position.
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YVONNE BALDUCCI, GERALD P. BODEY
1974 Volume 27 Issue 7 Pages
516-519
Published: 1974
Released on J-STAGE: April 12, 2006
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Kitasamycin was tested
in vitro against 214 clinical isolates of gram-positive cocci and its activity compared to minocycline, cephalothin, erythromycin, clindamycin and dicloxacillin. All isolates of
Streptococcus pyogenes were inhibited by 0.39μg/ml. At a concentration of 1.56μg/ml, kitasamycin inhibited all isolates of
Diplococcus pneumoniae, 98% of isolates of
Staphylococcus aureus sensitive to penicillin G and 99% of isolates of
Staphylococcus aureus resistant to penicillin G. Most of the other antibiotics were as active or more active than kitasamycin against gram-positive cocci.
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FRIEDA CASEY, GERALD P. BODEY
1974 Volume 27 Issue 7 Pages
520-524
Published: 1974
Released on J-STAGE: April 12, 2006
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BL-S217 is a new cephalosporin derivative which is active
in vitro against grampositivecocci and gram-negative bacilli. At a concentration of 12.5μg/ml, BL-S217inhibited 83% of isolates of
Klebsiella spp., 77% of isolates of
Escherichia coli and 67%of isolates of
Proteus mirabilis. BL-S217 was as active
in vitro as most other cephalosporinantibiotics.
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D. PERLMAN, T. ENDO, R. S. HINZ, S. K. COWAN, S. ENDO
1974 Volume 27 Issue 7 Pages
525-528
Published: 1974
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Bioassays of glycosides of neamine, kanamycin A and gentamicin C
1 showed that against most susceptible bacteria the potency was between 6 and 40% that of the parent compound. These alkali-labile and acid-stable glycosides appeared to be N-glycosides.
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FUSAO KONDO, NORITOSHI KITANO, HARUKI DOMON, MAMORU ARAI, TATSUO HANEI ...
1974 Volume 27 Issue 7 Pages
529-534
Published: 1974
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IV. ANTIMYCOPLASMA ACTIVITY OF ASPICULAMYCIN
in vitro AND IN VIVOkn-subtitle=en-abstract=Aspiculamycin, a new cytosine nucleoside antibiotic produced by
Streptomyces toyocaensis var.
aspiculamyceticus, showed strong activity against various strains of
Mycoplasma in vitro and
in vivo. The minimal inhibitory concentration of the antibiotic ranged between 50 to 0.05mcg/ml by agar dilution, broth dilution or microtiter method. No influences of inoculum size and pH of the medium on the activity were observed. A number of strains of
Mycoplasma gallisepticum showing resistance to macrolide antibiotics were all susceptible to the antibiotic. L-Forms derived from
Staphylococcus aureus and
Proteus vulgaris were insensitive to the antibiotic. After administration of 0.04% (w/w) of aspiculamycin in the basal diet for seven days, the lung and trachea of mice infected intranasally with
Mycoplasma pulmonis were free of pathogen. In the experimental mice arthritis induced with
M. pulmonis, the
Mycoplasma could not be detected in joints of the mice after treatment with aspiculamycin at a dose of 0.05% (w/w) in the diet for ten days.
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YOSUKE SAWADA, HYOZO TANIYAMA, NOBUO HANYUDA, HISASHI HAYASHI, TADASHI ...
1974 Volume 27 Issue 7 Pages
535-543
Published: 1974
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An antibiotic R4H exhibiting no delayed toxicity was isolated from the fermentation broth of
Streptomyces lavendulae strain R4. It was active against Gram-positive and -negative bacteria and
Mycobacterium. R4H was converted to racemomycin-A and racemomycinic-A acid by mild hydrolysis.
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II. STRUCTURAL IDENTIFICATION
RICHARD S. EGAN, SANDRA L. MUELLER, LESTER A. MITSCHER, ISAO KAWAMOTO, ...
1974 Volume 27 Issue 7 Pages
544-551
Published: 1974
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KIMIO MIZUNO, JUN MIYAZAWA, MASAKI TAKADA
1974 Volume 27 Issue 7 Pages
552-554
Published: 1974
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DETERMINATION OF DINACTIN, TRINACTIN AND TETRANACTIN IN THEIR MIXTURES BY NMR SPECTROSCOPY
MASATOSHI HANEDA, YOSHIHARU NAWATA, TOSHIAKI HAYASHI, KUNIO ANDO
1974 Volume 27 Issue 7 Pages
555-557
Published: 1974
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IV. PENICILLIC ACID
HARUO SETO, LEWIS W. CARY, MASATO TANABE
1974 Volume 27 Issue 7 Pages
558-559
Published: 1974
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KIMIO MIZUNO, AKIRA YAGI, MASAKI TAKADA, KAZUO MATSUURA, KIYOZUMI YAMA ...
1974 Volume 27 Issue 7 Pages
560-563
Published: 1974
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A. D. ARGOUDELIS, S. A. MIZSAK, P. A. MEULMAN
1974 Volume 27 Issue 7 Pages
564-566
Published: 1974
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HIROSHI OGAWARA, HAMAO UMEZAWA
1974 Volume 27 Issue 7 Pages
567-569
Published: 1974
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JERRY R. MARTIN, RICHARD S. EGAN, ALMA W. GOLDSTEIN, SANDRA L. MUELLER ...
1974 Volume 27 Issue 7 Pages
570-572
Published: 1974
Released on J-STAGE: April 12, 2006
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