巻号一覧
28 巻, 8 号
選択された号の論文の13件中1～13を表示しています
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TETSUO SHIBA, YASUO MUKUNOKI1975 年 28 巻 8 号 p. 561-566
発行日: 1975年
公開日: 2006/04/12
ジャーナル フリーThe peptide antibiotic longicatenamycin produced by a Streptomyces strain S-520 is a complex mixture of several congeners. The determination of the total structure of longicatenamycin was performed on the mixture using the procedure of N-bromosuccinimide oxidation followed by EDMAN degradation. The structure of the most abundant congener of longicatenamycin can be represented as cyclo (glycyl-L-2-amino-6-methylheptanoyl-D-valyl-D-ornithyl-threo-β-hydroxy-L-glutamyl-5-chloro-D-tryptophyl) (Fig. 1: 1=4, m=0, n=3). There are three amino acid positions in which variations are found. The antibiotic complex contains compounds in which L-2-amino-6-methylheptanoic acid is replaced with either L-2-amino-5-methylhexanoic acid or L-2-amino-7-methyloctanoic acid; further D-valine with D-isoleucine as well as D-ornithine with D-lysine.抄録全体を表示PDF形式でダウンロード (2979K) -
TERUO TANAKA1975 年 28 巻 8 号 p. 567-572
発行日: 1975年
公開日: 2006/04/12
ジャーナル フリーA convenient method was worked out which discriminates between inhibitory activity of compounds against Bacillus subtilis transformation and their antibacterial or growth inhibition activity. By this assay system, several drugs and antibiotics were tested and some of them were found to be more inhibitory to transformation than to bacterial growth.
This method was further applied to look for specific inhibitors among culture broths of Streptomyces, and during this screening program, Streptomyces sp. 7725-CC1 was found to produce a specific inhibitor of B. subtilis transformation. The active substance was purified and named antraformin after its specific action. The molecular weight was suggested to be 279 (C14H21N3O3) for the compound by high resolution mass spectrometry.抄録全体を表示PDF形式でダウンロード (2912K) -
I. SISOMICINR.T. TESTA, B.C. TILLEY1975 年 28 巻 8 号 p. 573-579
発行日: 1975年
公開日: 2006/04/12
ジャーナル フリーUtilizing a mutant of Micromonospora inyoensis which requires the addition of 2-deoxystreptamine for sisomicin production, the bioconversion of 2-deoxystreptamine containing pseudodisaccharides and pseudotrisaccharides into sisomicin was demonstrated. The trisaccharides tested were structurally related minor components found in the sisomicin or gentamicin fermentations. Based upon the specificity of the structural configuration of those compounds which were converted to sisomicin versus those which were not, a pathway for the biosynthesis of sisomicin is proposed.抄録全体を表示PDF形式でダウンロード (3167K) -
RELATION BETWEEN LIPOPHILY AND TOXICITYM. TALPAERT-BORLÈ, F. CAMPAGNARI, G. DISCENZA1975 年 28 巻 8 号 p. 580-589
発行日: 1975年
公開日: 2006/04/12
ジャーナル フリーThe chemical dimers of rifamycin SV resembled the corresponding monomeric analogs with respect to the inhibitory properties versus the nucleic acid polymerises. At low doses, such compounds blocked the initiation step of the DNA transcription catalyzed by the bacterial RNA polymerase, as observed for the parental antibiotic and its derivative rifampicin which are largely used in therapy. At concentrations one to two orders of magnitude higher, the chemically modified rifamycins inhibited also other nucleotidyltransferases. The widespread toxicity of the dimeric and monomeric semisynthetic rifamycins versus these enzymes was not causally related with an enhancement of their lipophily. The observed effects might be due to a loss of selectivity in the inhibition mechanism which was originally specific for the RNA polymerase from E. coli at the beginning of its catalysis. The rifamycin derivatives might then react with the catalytic portion of other nucleotidyltransferases interfering adversely with the enzyme activity in a number of ways and/or at different levels.抄録全体を表示PDF形式でダウンロード (5047K) -
E. YOURASSOWSKY, E. SCHOUTENS, M.P. VANDERLINDEN1975 年 28 巻 8 号 p. 590-593
発行日: 1975年
公開日: 2006/04/12
ジャーナル フリーIn vitro antibacterial activity of BL-S640 was compared to that of cephalothin and cephalexin against Gram-negative and Gram-positive bacteria isolated from clinical specimens. BL-S640 demonstrated the best activity on nearly all microbial species studied, except for Haemophilus influenzae and Diplococcus pneumoniae against which cephalothin was slightly more active.抄録全体を表示PDF形式でダウンロード (1719K) -
A NEW BROAD-SPECTRUM ORALLY-ACTIVE CEPHALOSPORINPAUL ACTOR, JOSEPH V. URI, LILLIAN PHILLIPS, CARL S. SACHS, JOSEPH R. ...1975 年 28 巻 8 号 p. 594-601
発行日: 1975年
公開日: 2006/04/12
ジャーナル フリーCefatrizine (SK&F 60771), a new orally-active semisynthetic cephalosporin antibiotic with broad-spectrum antibacterial activity, was compared with cephalexin and cefazolin for in vitro and in vivo antibacterial activity and pharmacokinetic behavior in laboratory animals. The average MIC values obtained with cefatrizine against gram-positive and gram-negative bacteria were superior to those obtained with cephalexin and somewhat poorer than those of cefazolin. In addition, a large percentage of the enterobacter and enterococcus isolates were found to be susceptible. Cefatrizine had a longer biological half-life and a higher peak serum level than either cefazolin or cephalexin when administered parenterally or orally to mice at 20 mg/kg. It had striking in vivo protective activity in mice infected with Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Hemophilus influenzae, Proteus morganii or Staphylococcus aureus reflecting its superior pharmacokinetic profile in this animal species. A variable pharmacokinetic response between animal species was observed when cefatrizine was administered either orally or parenterally to dogs, squirrel monkeys or rabbits.抄録全体を表示PDF形式でダウンロード (3782K) -
M. MATSUMOTO, H. MINATO, E. KONDO, T. MITSUGI, K. KATAGIRI1975 年 28 巻 8 号 p. 602-604
発行日: 1975年
公開日: 2006/04/12
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P. TRAXLER, H.J. TREICHLER, J. NÜESCH1975 年 28 巻 8 号 p. 605-606
発行日: 1975年
公開日: 2006/04/12
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KOJI O'HARA, MEGUMI KONO1975 年 28 巻 8 号 p. 607-608
発行日: 1975年
公開日: 2006/04/12
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S. OMURA, Y. SUZUKI, C. KITAO, Y. TAKAHASH, Y. KONDA1975 年 28 巻 8 号 p. 609-610
発行日: 1975年
公開日: 2006/04/12
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WINFRIED WINGENDER, HASSO VON HUGO, WERNER FROMMER, DIETMAR SCHÄF ...1975 年 28 巻 8 号 p. 611-612
発行日: 1975年
公開日: 2006/04/12
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KATSUHARU IINUMA, SHINICHI KONDO, KENJI MAEDA, HAMAO UMEZAWA1975 年 28 巻 8 号 p. 613-615
発行日: 1975年
公開日: 2006/04/12
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DAISHIRO IKEDA, FUMIKO NAGAKI, SUMIO UMEZAWA, TSUTOMU TSUCHIYA, HAMAO ...1975 年 28 巻 8 号 p. 616-618
発行日: 1975年
公開日: 2006/04/12
ジャーナル フリーPDF形式でダウンロード (1278K)
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