巻号一覧
29 巻, 6 号
選択された号の論文の15件中1～15を表示しています
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PIERRE GACHON, CHRISTIAN FARGES, ALAIN KERGOMARD1976 年 29 巻 6 号 p. 603-610
発行日: 1976年
公開日: 2006/04/12
ジャーナル フリーAlborixin, a polycyclic polyether ionophorous antibiotic, active against Gram-positive bacteria and fungi, was isolated from cultures of a strain of Streptomyces albus. The isolation, structure and physicochemical properties of this antibiotic are reported. Some derivatives have been prepared and their structures and properties are also described in this paper.抄録全体を表示PDF形式でダウンロード (3542K) -
I. PRODUCTION, BIOLOGICAL ACTIVITY, MICROBIOLOGICAL ASSAY AND TAXONOMY OF THE PRODUCING MICROORGANISML. J. HANKA, A. DIETZ1976 年 29 巻 6 号 p. 611-617
発行日: 1976年
公開日: 2006/04/12
ジャーナル フリーA new antitumor antibiotic, U-43, 120 was discovered. It is produced by fermentation of a new species of Streptomyces, designated Streptomyces paulus DIETZ sp. n. Its antimicrobial activity is limited to bacteria. A microbiological assay with Bacillus subtilis was developed that can detect concentrations of 1-2 μg/ml of the drug in fermentation liquors. U-43, 120 was active in vivo against P-388 leukemia in mice.抄録全体を表示PDF形式でダウンロード (2966K) -
I. FERMENTATION, ISOLATION AND CHARACTERIZATIONNAOYUKI INOUE, ATSUO INOUE, MINORU FURUKAWA, NOBUO KANDA1976 年 29 巻 6 号 p. 618-622
発行日: 1976年
公開日: 2006/04/12
ジャーナル フリーA new antibiotic, samarosporin, was isolated in a crystalline state from a mycelial extract of a strain of Samarospora species (an ascomycete). Samarosporin is a neutral cyclopeptide and has a molecular formula of C72H111N15O19. Samarosporin shows a broad antimicrobial activity against various test microorganisms.抄録全体を表示PDF形式でダウンロード (1967K) -
HIROYASU TOBE, HIROSHI NAGANAWA, TOMOHISA TAKITA, TOMIO TAKEUCHI, HAMA ...1976 年 29 巻 6 号 p. 623-625
発行日: 1976年
公開日: 2006/04/12
ジャーナル フリーA new dopa decarboxylase inhibiting isoflavone has been isolated from culture filtrates
of fungi and streptomyces and shown to be 3', 4', 5, 7-tetrahydroxy-8-methoxyisoflavone.抄録全体を表示PDF形式でダウンロード (1631K) -
SYNTHESIS OF RISTOBIOSE AND RISTOTRIOSEF. SZTARICSKAI, A. LIPTÁK, I. F. PELYVÁS, R. BOGNÁ ...1976 年 29 巻 6 号 p. 626-631
発行日: 1976年
公開日: 2006/04/12
ジャーナル フリーProof is given by synthesis confirming the structure of ristobiose as 2-O-α-D-mannopyranosyl-D-glucose (IV) and ristotriose as O-α-L-rhamnopyranosyl (1→6)-O-[α-D-mannopyranosyl (1→2)]-D-glucose (X) which are obtained from ristomycin A upon mild acid hydrolysis. Both oligosaccharides, IV and X, have been detected for the first time as the components of an antibiotic.抄録全体を表示PDF形式でダウンロード (3164K) -
H. BRIK1976 年 29 巻 6 号 p. 632-637
発行日: 1976年
公開日: 2006/04/12
ジャーナル フリーMild acid treatment of natamycin (IV) results in biologically inactive aponatamycin (VI), an amphoteric substance with some natamycin-like chemical and physical properties. Aponatamycin contains one natamycin- and one natamycinolide-moiety. More drastic acid degradation of natamycin eliminates the aminosugar under formation of the dimer (VII) of the hypothetical aglycone of natamycin, natamycinolide (V) as well as a non-ionic compound, the dimer of the 12-decarboxy-11-anhydro analogue of natamycinolide.抄録全体を表示PDF形式でダウンロード (2870K) -
INCORPORATION AND DISTRIBUTION OF LABELED COMPOUNDS INTO FORMYCINKOZO OCHI, SHINTARO KIKUCHI, SHIGETAKA YASHIMA, YOSHITOMO EGUCHI1976 年 29 巻 6 号 p. 638-645
発行日: 1976年
公開日: 2006/04/12
ジャーナル フリー1. Two carbons, carbon-2 and one of carbons-3 to -5, of lysine seemed likely to be incorporated into one of carbon of the chromophore moiety of formycin. 2. From the results of radioisotopic studies with glutamate, γ-amino-n-butyrate or organic acids related to tricarboxylic acid cycle, the important role of glutamate in the biosynthesis of formycin was strongly suggested. 3. The incorporation of nitrogen(s) of lysine into three nitrogens, including two nitrogens of pyrazole ring, of formycin was suggested by mass spectroscopy. 4. Ribose was estimated as a direct precursor for the ribosyl moiety of formycin, whereas the biosynthesis of ribose was shown to occur via the pathway other than hexose monophosphate shunt or glucuronate pathway. 5. In replacement culture, the salvage synthesis of formycin from its chromophore moiety was not observed and it was also evident that the chromophore moiety or pyrazofurin (pyrazomycin) inhibited the biosynthesis of formycin.抄録全体を表示PDF形式でダウンロード (4312K) -
ISOLATION OF A PEROXIDASER. SURETTE, L. C. VINING1976 年 29 巻 6 号 p. 646-652
発行日: 1976年
公開日: 2006/04/12
ジャーナル フリーCultures of Streptomyces lincolnensis accumulated 3-methylthioacrylic acid in amounts directly related to the concentration of methionine in the medium. The metabolite was labeled by L-(methyl-14C) but not by DL-(carboxyl-14C) methionine, indicating biosynthesis from the amino acid with loss of the carboxyl group. S. lincolnensis mycelium contained sufficient peroxidase activity to catalyse oxidative decarboxylation of L-methionine to 3-methylthiopropionamide as the initial step of a biosynthetic sequence. The enzyme, partially purified by ammonium sulfate precipitation, chromatography on a DEAE-cellulose column and gel filtration, had a molecular weight of approximately 350, 000, a pH optimum of 6.0, with o-dianisidine as electron donor and a Km value of 7.5×10-4 M with respect to hydrogen peroxide. Cultures of S. lincolnensis supplemented with 3-(methyl-14C) methylthiopropionic acid gave labeled 3-methylthioacrylic acid. However, 3-(methyl-14C) methylthiopropionamide did not label the metabolite, suggesting that the first intermediate in the pathway may be the keto acid, which is then oxidatively decarboxylated to 3-methylthiopropionic acid.抄録全体を表示PDF形式でダウンロード (3897K) -
O. ZAK, W. A. VISCHER, C. SCHENK, W. TOSCH, W. ZIMMERMANN, J. REGÖ ...1976 年 29 巻 6 号 p. 653-655
発行日: 1976年
公開日: 2006/04/12
ジャーナル フリーCGP 9000, (7-[D-2-amino-2-(1, 4-cyclohexadienyl)-acetamido]-3-methoxy-3-cephem-4-
carboxylic acid), is a new broad-spectrum cephalosporin antibiotic. Its antibacterial activity
in vitro (MIC) is similar, but its bactericidal efficacy superior to that of cephalexin and cephradine.
Upon oral administration to mice infected with various bacteria, CGP 9000 is, in
general, 2 to 7 times more effective than either cephalexin or cephradine.抄録全体を表示PDF形式でダウンロード (1312K) -
NEIL I. GOLDSTEIN, ARTHUR H. MCINTOSH, PAUL B. FISHER, KARL MARAMOROSC ...1976 年 29 巻 6 号 p. 656-661
発行日: 1976年
公開日: 2006/04/12
ジャーナル フリーThe polyene macrolide antibiotic amphotericin B (AB) and its chemically modified derivative amphotericin B methyl ester (AME) were tested for in vitro activity against Acholeplasma laidlawii, Spiroplasma citri and Mycoplasma gallisepticum. Both polyene macrolide preparations demonstrated anti-mycoplasmal activity. However, AME was mycoplasmacidal toward all three strains of mycoplasma at levels which previous studies have indicated would be permissible for most cell culture systems, whereas the levels of AB required for similar activity would be physiologically intolerable for tissue culture cells. In addition, AME was 100 fold more active than AB toward A. laidlawii, 10 fold more active than AB toward S. citri and demonstrated equivalent activity as AB toward M. gallisepticum. The in vitro anti-mycoplasmal activity of AME and AB was directly correlated with polyene macrolide antibiotic levels and the number of treated mycoplasma.抄録全体を表示PDF形式でダウンロード (2897K) -
GOHTA MASUDA, SUSUMU TOMIOKA, MITSUTO HASEGAWA1976 年 29 巻 6 号 p. 662-664
発行日: 1976年
公開日: 2006/04/12
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MITSUO EBATA, YUKIO MIYAKE, JUNKO UCHIDA1976 年 29 巻 6 号 p. 665-666
発行日: 1976年
公開日: 2006/04/12
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A. G. BROWN, D. BUTTERWORTH, M. COLE, G. HANSCOMB, J. D. HOOD, C. READ ...1976 年 29 巻 6 号 p. 668-669
発行日: 1976年
公開日: 2006/04/12
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RICHARD WAX, WILLIAM MAIESE, ROY WESTON, JEROME BIRNBAUM1976 年 29 巻 6 号 p. 670-673
発行日: 1976年
公開日: 2006/04/12
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TOMONOBU KUSANO, KAZUO IZAKI, HAJIME TAKAHASHI1976 年 29 巻 6 号 p. 674-675
発行日: 1976年
公開日: 2006/04/12
ジャーナル フリーPDF形式でダウンロード (1002K)
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