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A. D. ARGOUDELIS, T. R. PYKE, R. W. SPRAGUE
1976 Volume 29 Issue 8 Pages
777-786
Published: 1976
Released on J-STAGE: April 12, 2006
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Rancinamycins I, II, III and IV are secondary metabolites produced by
Streptomyces lincolnensis in a sulfur-depleted culture medium. Rancinamycins I and II, the main components of the mixture, show broad spectrum antibiotic activity
in vitro. Subcutaneously injected or
orally administered antibiotic afforded no protection for experimentally infected mice against lethal challenges of
Staphylococcus aureus. Radioactive tracer studies failed to demonstrate that the rancinamycins were precursors in the biosynthesis of lincomycin.
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A. D. ARGOUDELIS, R. W. SPRAGUE, S. A. MIZSAK
1976 Volume 29 Issue 8 Pages
787-796
Published: 1976
Released on J-STAGE: April 12, 2006
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Rancinamycins are secondary metabolites produced by
Streptomyces lincolnensis in a sulfur-depleted culture medium. The structures (except stereochemistry) of the main components of the rancinamycin-complex were determined by the use of IR, UV, PMR and CMR spectra.
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SATOSHI OMURA, YUZURU IWAI, YOKO SUZUKI, JUICHI AWAYA, YAEKO KONDA, MA ...
1976 Volume 29 Issue 8 Pages
797-803
Published: 1976
Released on J-STAGE: April 12, 2006
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Two metabolites have been isolated from the fermentation broth of a new species of
Kitasatoa, Kitasatoa griseophaeus. These alkaloids have been identified as quinoline-2- methanol and quinoline-2-methanol acetate. The former exhibits hypoglycemic activity in the rat.
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TADAYUKI ISHIYAMA, TOYOSHIGE ENDO, NOBORU OTAKE, HIROSHI YONEHARA
1976 Volume 29 Issue 8 Pages
804-808
Published: 1976
Released on J-STAGE: April 12, 2006
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A new antifungal antibiotic was isolated from the fermentation broth of
Streptolnrces sp. 5140-A
1. Degradation studies of the crystalline antibiotic, m.p. 186-188°C, C
21H
28O
8N
2, suggested its structure to be deisovaleryl-blastmycin. It exhibited antimicrobial activity against
Piricularia oryzae and less toxicity against killifish than antimycin A-blastmycin antibiotics.
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STUDIES ON ANTIBIOTICS FROM THE GENUS BACILLUS. XIV
JUN'ICHI SHOJI, HIROSHI HINOO, YOSHIHARU WAKISAKA, KENZO KOIZUMI, MIKA ...
1976 Volume 29 Issue 8 Pages
809-812
Published: 1976
Released on J-STAGE: April 12, 2006
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A new antibiotic, named 339-29, active against Gram-positive bacteria was isolated from a strain of
Bacillus pumilus. The hydrochloride is soluble in water and aqueous alcohols. The antibiotic is a basic peptide containing valine (3), isoleucine (1), leucine (2), tyrosine(1), lysine (3) and a fatty acid.
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STUDIES ON ANTIBIOTICS FROM THE GENUS BACILLUS
JUN'ICHI SHOJI, HIROSHI HINOO, YOSHIHARU WAKISAKA, KENZO KOIZUMI, MIKA ...
1976 Volume 29 Issue 8 Pages
813-817
Published: 1976
Released on J-STAGE: April 12, 2006
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A new peptide antibiotic complex, B-43, active against Gram-positive and Gram-negative bacteria, was isolated from a strain of Bacillus circulans. This antibiotic contains aspartic acid, valine, isoleucine, leucine, phenylalanine and 2, 4-diaminobutyric acid. It seems to be related to polypeptin and antibiotic complex 4205, but differs in that it contains aspartic acid residue.
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A. D. ARGOUDELIS, S. A. MIZSAK
1976 Volume 29 Issue 8 Pages
818-823
Published: 1976
Released on J-STAGE: April 12, 2006
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1-Methylpseudouridine is a new metabolite isolated from culture filtrates of
Streptomyces platensis. The structure of this compound was determined from its physical and spectral properties.
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II. ADDITIONAL TRANSFORMATION PRODUCTS OF MARIDOMYCIN III
MOTOO SHIBATA, MASARU UYEDA, SHINYA MORI
1976 Volume 29 Issue 8 Pages
824-828
Published: 1976
Released on J-STAGE: April 12, 2006
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Streptomyces sp. strain No. K-245 was found to transform maridomycin III into four derivatives (A
1, A
2, A
3 and A
4) in addition to the transformation products reported previously. Isolation of the main product A
1 was carried out by column chromatography on silica gel developed with CHCl
3-MeOH (19:1). From the partial investigation of the structure of A
1 it proved to have a C 18-aldehyde group and C 4"-propionyl group but no antimicrobial activity. The relationships between A group's derivatives and known derivatives of maridomycin III are also discussed.
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PAUL STEVENS, LOWELL S. YOUNG, WILLIAM L. HEWITT
1976 Volume 29 Issue 8 Pages
829-832
Published: 1976
Released on J-STAGE: April 12, 2006
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A radioimmunoassay (RIA) has been developed using
125I-amikacin. Amikacin was iodinated by a modified BOLTON and HUNTER method. Dextran-charcoal was used to separate bound from free drug. The standard curve was linear on a logit-log plot in the range of 0.5ng to 4ng amikacin per tube. There was no cross-reactivity of amikacin antisera to the aminoglycosides gentamicin, tobramycin, netilmicin, and sisomicin but a 70% cross-reaction was observed with kanamycin, the compound from which amikacin is synthetically derived. Correlation of the RIA with a microbioassay for the determination of serum amikacin levels in 18 patient samples was excellent (r=0.94). This new RIA technique is more sensitive, rapid, versatile, and less costly than the RIA using
3H-amikacin, and is far more sensitive and faster than microbioassay.
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TETSUTARO NIIZATO, TAKEMI KOEDA, TAKASHI TSURUOKA, SHIGEHARU INOUYE, T ...
1976 Volume 29 Issue 8 Pages
833-840
Published: 1976
Released on J-STAGE: April 12, 2006
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The nephrotoxicity of rats caused by dibekacin (3', 4'-dideoxykanamycin B) or kanamycin, with or without dextran was effectively reduced by D-glucaro-δ-Iactam potassium salt, as evidenced by lower levels of blood urea nitrogen and kidney edema rate, better excretion of antibiotics, and less morphological damage. Protection was dosage related, and potentiated with increasing doses, but only when the two drugs were given simultaneously. Among three alkali-metal salts examined, the potassium salt was almost equal to the lithium salt, but surpassed the sodium salt in effectiveness.
Inorganic salts, in particular potassium chloride were found to be effective for the protection of normal rats, but their effect decreased for the dehydrated rats, especially in the presence of dextran.
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AKIRA ENDO, MASAO KURODA
1976 Volume 29 Issue 8 Pages
841-843
Published: 1976
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TAKESHI KAWAMURA, TSUTOMU KIMURA, KUNIHIKO TAGO, TERUHIKO BEPPU, KEI A ...
1976 Volume 29 Issue 8 Pages
844-846
Published: 1976
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HISAO KONDO, MASATO UEHARA, SEITARO NAKAMA, TOSHIO OTANI, SHOSHIRO NAK ...
1976 Volume 29 Issue 8 Pages
847-849
Published: 1976
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J. R. EVANS, EUNICE J. NAPIER, PATRICIA YATES
1976 Volume 29 Issue 8 Pages
850-852
Published: 1976
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YASUHIKO MURAOKA, HIROKO KOBAYASHI, AKIO FUJII, MAMORU KUNISHIMA, TOSH ...
1976 Volume 29 Issue 8 Pages
853-856
Published: 1976
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HAMAO UMEZAWA, MASAAKI ISHIZUKA, TAKAAKI AOYAGI, TOMIO TAKEUCHI
1976 Volume 29 Issue 8 Pages
857-859
Published: 1976
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GENNARO J. MIRAGLIA, HAROLD BASCH, PATRICIA LUKASZOW, KATHLEEN J. RENZ ...
1976 Volume 29 Issue 8 Pages
860-862
Published: 1976
Released on J-STAGE: April 12, 2006
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