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SATOSHI OMURA, YUZURU IWAI, ATSUSHI HIRANO, AKIRA NAKAGAWA, JUICHI AWA ...
1977 Volume 30 Issue 4 Pages
275-282
Published: 1977
Released on J-STAGE: April 12, 2006
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AM-2282, a new alkaloid has been isolated from cultures of
Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD
50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 has been determined as C
28H
26N
4O
3. The producing strain, AM-2282 was classified as a new species and the name,
Streptomyces staurosporeus AWAYA, TAKAHASHI and OMURA, nov. sp. is proposed.
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COMPOUND 102804 FROM BACILLUS CEREUS
MASAO KAGEYAMA, KATHRYN A. BURG, D. PERLMAN
1977 Volume 30 Issue 4 Pages
283-288
Published: 1977
Released on J-STAGE: April 12, 2006
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A basic compound with empirical formula C
12H
16N
2O
5 was isolated from
Bacillus cereus102804 fermentations of a soybean meal - glucose medium. The inhibitory activity of compound 102804 on growth of Gram-positive and Gram-negative bacteria growing in a chemically defined medium was reversed by vitamin B
12, by L-methionine, and by D-methionine. It has no inhibitory activity for
Escherichia coli (Davis 113-3) when grown in media containing L-methionine.
The biosynthesis of 102804 coincides with the sporulation of the
B. cereus, and the compound is not produced in the absence of sporulation.
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I. FERMENTATION, ISOLATION, CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF PAPULACANDINS A, B, C, D AND E
P. TRAXLER, J. GRUNER, J. A. L. AUDEN
1977 Volume 30 Issue 4 Pages
289-296
Published: 1977
Released on J-STAGE: April 12, 2006
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Papulacandin, a new antibiotic complex, active against
Candida albicans and several other yeasts, was isolated from a strain of
Papularia sphaerosperma. The fermentation, isolation, physico-chemical properties and biological activity of the five structurally related papulacandins A, B, C, D and E are reported. Papulacandin B, the main component, was assigned the formula of C
47H
64O
17.
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I ISOLATION AND CHARACTERIZATION OF ACULEACIN A
KIMIO MIZUNO, AKIRA YAGI, SHUZO SATOI, MASAKI TAKADA, MITSUO HAYASHI, ...
1977 Volume 30 Issue 4 Pages
297-302
Published: 1977
Released on J-STAGE: April 12, 2006
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Aculeacin A, a new antifungal antibiotic was isolated from the mycelial cake of
Aspergillus aculeatus M-4214. The antibiotic is a white amorphous powder soluble in lower alcohols and hardly soluble in other organic solvents or water. Aculeacin A gave palmitic acid and five ninhydrin-positive products including threonine, hydroxyproline upon acid hydrolysis. The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity. Aculeacin A has relatively low toxicity in mice.
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ISOLATION AND CHARACTERIZATION OF ACULEACINS B, C, D, E, F and G
SHUZO SATOI, AKIRA YAGI, KATSUMI ASANO, KIMIO MIZUNO, TETSUO WATANABE
1977 Volume 30 Issue 4 Pages
303-307
Published: 1977
Released on J-STAGE: April 12, 2006
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Six new antibiotics were isolated as the minor components related to aculeacin A from the culture broth of
Aspergillus aculeatus M-4214 and named as aculeacins B, C, D, E, F and G. Their physico-chemical properties were analogous to those of aculeacin A and they showed significant activity against fungi. All of the minor components liberated palmitic acid on alkaline hydrolysis. Amino acid analysis showed that threonine and hydroxyproline are common constituents of aculeacins.
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JUNZO MIZOGUCHI, TETSU SAITO, KIMIO MIZUNO, KAZUO HAYANO
1977 Volume 30 Issue 4 Pages
308-313
Published: 1977
Released on J-STAGE: April 12, 2006
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The mode of action of a new antifungal antibiotic, aculeacin A, was studied with the cells of
Saccharomyces cerevisiae. In the presence of aculeacin A, the distinct decrease of viable cells was observed. The most of cells treated with aculeacin A lysed with releasing intracellular substances at the tips of their buds. This lysis was considered to be due to the inhibition of cell wall synthesis, because the incorporation of glucose into the cell wall glucan was significantly reduced. Aculeacin A also had a weak activity to burst the protoplasts of
S. cerevisiae at a relatively high concentration.
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GAMAL M. IMAM, HANS KÜNTZEL
1977 Volume 30 Issue 4 Pages
314-320
Published: 1977
Released on J-STAGE: April 12, 2006
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The two antibiotics ASN-136 and monoketo-organomycin (MKOM) showed very close similarities in their UV, IR spectra and elemental analysis to those of tuberactinomycin and yazumycin respectively. Further chemical and enzymic studies revealed the novelty of the two former antibiotics. Partial enzymic hydrolysis of MKOM yielded a hydrolytic product of more potent inhibitory action compared with the parent antibiotic. Having cystine as the N-terminus and taurine as the C-terminus in its molecule, this enzymic degradation product was designated cystaurimycin. Performic acid oxidation of MKOM and of cystaurimycin improved their growth inhibitory effects on the test organisms used.
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NEIL I. GOLDSTEIN, PAUL B. FISHER, CARL P. SCHAFFNER
1977 Volume 30 Issue 4 Pages
321-325
Published: 1977
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The effect of amphotericin B (AB) and amphotericin B methyl ester (AME) on viability and DNA synthesis in three insect cell lines,
Trichoplusia ni (Tn),
Carpocapsa pomonella 169 (Cp) and
Aedes aegypti (Aa), has been evaluated. In all cases AME was less toxic than AB and inhibited DNA synthesis to a lesser degree than AB. However, the three cell lines differed in their response to the two polyene macrolide antibiotic preparations. Tn and Aa cell responded in a similar manner when exposed to either AME or AB, whereas Cp cells were more sensitive to both antibiotics than Tn or Aa cells.
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RICHARD D. MEYER
1977 Volume 30 Issue 4 Pages
326-329
Published: 1977
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The
in vitro antibacterial activity of two agents relatively resistant to beta-lactamases, BL-S786 and cefoxitin, was tested against 123 recent different clinical isolates of cephalothin-resistant
Enterobacteriaceae. BL-S786 showed considerable activity against
Escherichia coli and lesser activity against
Klebsiella pneumoniae with, respectively, 68% and 41% inhibited at 32 μg/ml. Cefoxitin showed more activity
in vitro against
E. coli, K. pneumoniae, Serratia marcescens and
Providencia stuartii. Cefoxitin appears to be a more promising agent for treating infections caused by cephalothin-resistant
Enterobacteriaceae.
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MASAYUKI SHIMADA, HIROKO HONDA, JUICHI AWAYA, SATOSHI OMURA
1977 Volume 30 Issue 4 Pages
330-331
Published: 1977
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TAKASHI YAMAGUCHI, KAZUHIRO KAMIYA, TOSHIHITO MORI, TAKESHI ODA
1977 Volume 30 Issue 4 Pages
332-333
Published: 1977
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KAZUHIKO OKAMURA, KATSUYOSHI SOGA, YASUTAKA SHIMAUCHI, TOMOYUKI ISHIKU ...
1977 Volume 30 Issue 4 Pages
334-336
Published: 1977
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HIROSHI OGAWARA, SETSUKO NOZAKI
1977 Volume 30 Issue 4 Pages
337-339
Published: 1977
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MASASHI MIYAMOTO, SHINICHI KONDO, HIROSHI NAGANAWA, KENJI MAEDA, MASAJ ...
1977 Volume 30 Issue 4 Pages
340-343
Published: 1977
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J. P. KIRBY, G. E. VAN LEAR, G. O. MORTON, W. E. GORE, W. V. CURRAN, D ...
1977 Volume 30 Issue 4 Pages
344-347
Published: 1977
Released on J-STAGE: April 12, 2006
JOURNAL
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