The Journal of Antibiotics

NOVEL ANTITUMOR AGENTS CI-920, PD 113, 270 AND PD 113, 271

I. TAXONOMY, FERMENTATION AND BIOLOGICAL PROPERTIES

J. B. TUNAC, B. D. GRAHAM, W. E. DOBSON

1983 Volume 36 Issue 12 Pages 1595-1600
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1595

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CI-920 (PD 110, 161) and two analogues (PD 113, 270 and PD 113, 271) are novel antitumor compounds produced by a new actinomycete characterized as Streptomyces pulveraceus subsp. fostreus ATCC 31906. The antitumor compounds are predominantly produced during the stationary (idiophase) growth phase of the organism. CI-920 is active versus the murine P388 lymphocytic and L1210 lymphoid leukemia with T/C values of 246 and 207, respectively. This compound has no significant antimicrobial activity.

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NOVEL ANTITUMOR AGENTS CI-920. PD 113.270 AND PD 113, 271

II. ISOLATION AND CHARACTERIZATION

S. S. STAMPWALA, R. H. BUNGE, T. R. HURLEY, N. E. WILLMER, A. J. BRANK ...

1983 Volume 36 Issue 12 Pages 1601-1605
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1601

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A complex of structurally related compounds that exhibit in vivo antileukemic activity was isolated from fermentation broths of a new streptomycete. The components of this complex are water soluble phosphate esters containing a conjugated triene system. The isolation and characterization of three of these components are described.

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STUDIES ON PEPTIDE ANTIBIOTICS, LEUCINOSTATINS

I. SEPARATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES OF LEUCINOSTATINS A AND B

KAZUTAKA FUKUSHIMA, TADASHI ARAI, YUJI MORI, MAKOTO TSUBOI, MAKOTO SUZ ...

1983 Volume 36 Issue 12 Pages 1606-1612
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1606

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Leucinostatin, a peptide antibiotic, was separated by silica gel and alumina column chromatography into two related components designated as leucinostatin A hydrochloride (C₆₁H₁₁₁N₁₁O₁₃•HCl) and leucinostatin B hydrochloride (C₆₁H₁₀₉N₁₁O₁₃•HCl). Physico-chemical as well as biological properties of the two separated components were analyzed. These properties pointed to closely resembling chemical structures.

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STUDIES ON PEPTIDE ANTIBIOTICS, LEUCINOSTATINS

II. THE STRUCTURES OF LEUCINOSTATINS A AND B

KAZUTAKA FUKUSHIMA, TADASHI ARAI, YUJI MORI, MAKOTO TSUBOI, MAKOTO SUZ ...

1983 Volume 36 Issue 12 Pages 1613-1630
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1613

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Structures I and II have been assigned to leucinostatins A and B based on fast atom bombardment, secondary ion, field desorption and chemical ionization mass spectrometry, NMR studies and chemical degradation methods of the intact antibiotics and their acid hydrolysis products.
The essential difference between leucinostatins A and B is concluded to be the replacement of (2S)-N¹, N¹-dimethylpropane-1, 2-diaminein leucinostatin A by (2S)-N¹-methylpropane-1, 2-diamine in leucinostatin B. This was further confirmed from the evidence that methylation with methyl iodide led each antibiotic to the identical compound which was named leucinostatin A-M (III).

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MM 14201, A NEW EPOXYQUINONE DERIVATIVE WITH ANTIBACTERIAL ACTIVITY PRODUCED BY A SPECIES OF STREPTOMYCES

S. J. BOX, M. L. GILPIN, M. GWYNN, G. HANSCOMB, S. R. SPEAR, A. G. BRO ...

1983 Volume 36 Issue 12 Pages 1631-1637
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1631

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A new antibiotic designated MM 14201 has been detected in a culture of Streptomyces sp. NCIB 11813. Methods for the production and purification of MM 14201 are described. Biological evaluation has shown it has broad spectrum antibacterial activity being most effective against Serratia and Pseudomonas sp. Structural studies are reported which have demonstrated MM 14201 is a new epoxyquinone derivative.

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NEW STREPTOTHRICIN-GROUP ANTIBIOTICS, AN-201 I AND II

SCREENING, FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

SHIGEYOSHI MIYASHIRO, TOSHIHIKO ANDO, KAZUO HIRAYAMA, TAKAO KIDA, HIRO ...

1983 Volume 36 Issue 12 Pages 1638-1643
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1638

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Two streptothricin-group antibiotics, AN-201 I and II, were newly discovered and isolated from the culture broth of Streptomyces nojiriensis C-13. These antibiotics were purified by IRC-50 (H⁺) and CM-Sephadex C-50 chromatography, and paper electrophoresis. Structural analysis of AN-201 I and II showed that they were N^β-acetylated derivatives of streptothricin E and D, respectively. They had antibacterial activities against several strains of Escherichia coli, Bacillus subtilis, Micrococcus luteus and Staphylococcus aureus, and showed a strong selective cytotoxic effect on 3T3 cells transformed with SV-40 as compared with their normal cells in a test system in vitro as well as in vivo.

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HISTIDINOMYCIN, A NEW ANTIFUNGAL ANTIBIOTIC

KURUMI ISHIMARU, JUNKO ISHIDA, NORIKO NOBORIO, SHOSHIRO NAKAMURA

1983 Volume 36 Issue 12 Pages 1644-1650
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1644

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A new antifungal antibiotic named histidinomycin was isolated from the broth filtrate of a streptomycete, tentatively designated as isolate H 878-MY 1. Histidinomycin was purified as the monohydrochloride and the molecular formula was proposed to be C₂₂H₃₀N₈O₁₁•HCl. The antibiotic gave histidine by acid hydrolysis. Histidinomycin showed rather narrow antimicrobial spectrum for only few genera of phytophathogenic fungi.

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THE MYXOPYRONINS, NEW INHIBITORS OF BACTERIAL RNA SYNTHESIS FROM MYXOCOCCUS FULVUS (MYXOBACTERALES)

H. IRSCHIK, K. GERTH, G. HÖFLE, W. KOHL, H. REICHENBACH

1983 Volume 36 Issue 12 Pages 1651-1658
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1651

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From the culture supernatant of the myxobacterium, Myxococcus fulvus strain Mx f50, an antibiotic activity was isolated which blocked growth of many Gram-positive and several Gram-negative bacteria, but not of yeasts and fungi. The activity consisted of two closely related compounds, myxopyronins A and B. The myxopyronins appear to be new antibiotics, and seem to specifically inhibit bacterial RNA polymerase.

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FUSIDANE ANTIBIOTICS PRODUCED BY DERMATOPHYTES

M. J. PERRY, A. HENDRICKS-GITTINS, L. M. STACEY, M. W. ADLARD, W. C. N ...

1983 Volume 36 Issue 12 Pages 1659-1663
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1659

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Isolates of Microsporum canis, Microsporum gypseum and Epidermophyton floccosum were observed to produce antibacterial activities under cross-resistance to fusidic acid. The activity from E. floccosum was shown to be due to fusidic acid, diketofusidic acid and 3-ketofusidic acid. Possible contributions of these antibiotics to microbial interaction during dermatophytosis is discussed.

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CONVERSION OF TRIOSTINS TO QUINOMYCINS BY PROTOPLASTS OF STREPTOMYCES ECHINATUS

ALEX CORNISH, MICHAEL J. WARING, ROBERT D. NOLAN

1983 Volume 36 Issue 12 Pages 1664-1670
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1664

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Protoplasts of Streptomyces echinatus have been used to investigate the biosynthesis of echinomycin (quinomycin A). It has been shown that this organism has the capacity to convert a series of triostins to the corresponding quinomycins by a mechanism involving methylation. Evidence is presented which suggests that triostin A is the natural precursor of echinomycin. Conversion of tetra-N-demethyl analogues of triostin A to corresponding analogues of echinomycin was not detected.

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COMPONENTS AND DEGRADATION COMPOUNDS OF THE AVOPARCIN COMPLEX

W. J. MCGAHREN, R. A. LEESE, F. BARBATSCHI, G. O. MORTON, N. A. KUCK, ...

1983 Volume 36 Issue 12 Pages 1671-1682
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1671

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The isolation and characterization of many of the components of the avoparcin complex are described. A number of mild degradations products from this complex are similarly treated. Conditions for the analytical and preparative HPLC resolution of these materials are outlined.

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EPIMERIZATION AND STEREOCHEMISTRY OF AVOPARCIN

G. A. ELLESTAD, W. SWENSON, W. J. MCGAHREN

1983 Volume 36 Issue 12 Pages 1683-1690
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1683

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The epimerization of avoparcin entities is discussed in some detail. The absolute stereochemistry of avoparcin is now known since the N-methyl terminal amino acid of the aglycone has been isolated and shown to exhibit negative optical rotation and hence has the R-configuration. The same amino acid has been isolated from an epimerized solution of avoparcin and found to have positive rotation and hence the S-configuration. A comparison is made of the CD curves of β-avoparcin and epi-β-avoparcin. Some discussion on the effect of protonation of the terminal N-methyl group on the antibacterial activity of avoparcin is included.

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HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) OF ANTIBIOTICS OF VANCOMYCIN TYPE COMPARATIVE STUDIES

F. SZTARICSKAI, J. BORDA, M. M. PUSKÁS, R. BOGNÁR

1983 Volume 36 Issue 12 Pages 1691-1698
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1691

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Comparative HPLC examination of seven antibiotics of vancomycin type has been undertaken. Investigation has shown that on column I in eluent system B, ristomycin A (ristocetin A) can be not only separated from vancomycin, but both antibiotics can be quantitatively determined. Under these conditions the lowest detectable quantities of the individual antibiotics have been also stated. By the application of this column and eluent system A, ristomycin A (ristocetin A) and the major component of the A-35512 B antibiotic complex can be readily separated from one-another and from avoparcin α and β.

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STUDIES ON TOMAYMYCIN.

III. SYNTHESES AND ANTITUMOR ACTIVITY OF TOMAYMYCIN ANALOGS

ZENZABURO TOZUKA, HISATOYO YAZAWA, MASAYOSHI MURATA, TAKAO TAKAYA

1983 Volume 36 Issue 12 Pages 1699-1708
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1699

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The syntheses and antitumor activity of tomaymycin analogs are described. Structural modification of such parts of tomaymycin as the ethylidenepyrrole ring, aminal bond, and substituents of the benzene ring are discussed.

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RIBOSOME-BINDING ACTIVITIES AND ANTIMICROBIAL ACTIVITIES OF TYLOSIN AND ITS RELATED COMPOUNDS

SATOSHI OMURA, JUNJI INOKOSHI, HAJIME MATSUBARA, HARUO TANAKA

1983 Volume 36 Issue 12 Pages 1709-1712
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1709

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Structure-activity relationships of tylosin and related compounds were evaluated in terms of their antimicrobial and ribosome-binding activities. Demycarosyl derivatives, demycarosyltylosin and 20-deoxydemycarosylrelomycin, were slightly weaker than tylosin and 20-deoxyrelomycin, respectively, both in antimicrobial activity and in affinity to ribosomes. The corresponding demycarosyl-demycinosyl derivatives had weaker antimicrobial activities despite their relatively high affinities to ribosomes. A 23-deoxy-demycarosyl-demycinosyl derivative, 20-oxo-5-O-mycaminosylprotylonolide, had a higher affinity to ribosomes than that of tylosin and was equivalent to tylosin in antimicrobial activity against Gram-positive bacteria. These results suggest that the mycinose moiety increases the ability of the molecule to enter bacterial cells. Among the derivatives tested, a 23-iodo derivative, 20-deoxy-23-iodo-5-O-mycarosyltylonolide, had the highest affinity for ribosomes as well as the highest antimicrobial activity.

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CHEMICAL MODIFICATION OF TYLOSIN: SYNTHESIS OF AMINO DERIVATIVES AT C-20 POSITION OF TYLOSIN AND DEMYCAROSYLTYLOSIN

HAJIME MATSUBARA, JUNJI INOKOSHI, AKIRA NAKAGAWA, HARUO TANAKA, SATOSH ...

1983 Volume 36 Issue 12 Pages 1713-1721
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1713

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Reductive aminations of the aldehyde group at C-20 position of tylosin and demycarosyltylosin (desmycosin) were carried out using primary and secondary amines in the presence of sodium cyanoborohydride. Some of these derivatives brought about higher antimicrobial and ribosome-binding activities, and the structure-activity relationship is discussed.

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MICROBIAL TRANSFORMATION OF MARIDOMYCIN III BY SERRATIA MARCESCENS

MASARU UYEDA, KUNIHIKO KUBOTA, SHIGEYUKI MIYAMURA, MOTOO SHIBATA

1983 Volume 36 Issue 12 Pages 1722-1728
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1722

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Two transformation products of maridomycin (MDM) III, MDM-S₁ and MDM-S₂ named after Serratia marcescens, were isolated by silica gel chromatography. NMR and IR analysis revealed that MDM-S₁ and -S₂ had no aldehyde group at C-18 on the macrolactone ring, and that the hydroxyl group at C-9 seemed to disappear. Although MDM-S₁ and -S₂ are less active against Gram-positive bacteria than starting MDM III. they are interesting materials in view of the introduction of nitrogen into each molecule, and that the transformation products are produced by Gram-negative bacteria which are thought to be insensitive to macrolide antibiotics.

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ANTIBACTERIAL ACTIVITY OF PALMITOYLTUBERACTINAMINE N AND DI-β-LYSYLCAPREOMYCIN IIA

TAKESHI YAMADA, TAKAHISA YAMANOUCHI, YASUKO ONO, AKIHISA NAGATA, TATEA ...

1983 Volume 36 Issue 12 Pages 1729-1734
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1729

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Palmitoyltuberactinamine N (Pal-Tua N) and di-β-lysylcapreomycin IIA (di-β-Lys-Cpm IIA), which are synthetic derivatives of the antituberculous agent tuberactinomycin (Tum) and capreomycin (Cpm) respectively, were tested for anti-bacterial activity. Pal-Tua N inhibited not only tuberactinomycin-resistant Mycobacterium smegmatis but also Escherichia coli, Corynebacterium diphtheriae, Staphylococcus aureus, Streptococcus pyogenes, although it has lost activity against Mycobacterium tuberculosis. Di-β-Lys-Cpm IIA inhibited the growth of laboratory-derived Tum-resistant M. smegmatis and M. tuberculosis as well as Tum-resistant M. tuberculosis from patients with one exceptional case.

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THE BIOSYNTHESIS OF BROMINATED PYRROLNITRIN DERIVATIVES BY PSEUDOMONAS AUREOFACIENS

KARL-HEINZ VAN PÉE, OLGA SALCHER, PETER FISCHER, MICHAEL BOKEL, ...

1983 Volume 36 Issue 12 Pages 1735-1742
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1735

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The mutant strain ACN of Pseudoinonas aureofaciens ATCC 15926 produces several bromo derivatives of pyrrolnitrin. Five brominated amino- and three brominated nitrophenyl pyrrole compounds could be isolated, and their structures were established by ¹H NMR, UV and mass spectroscopy. The isolated amino compounds showed no biological activity; the nitro derivatives inhibited the growth of Neurospora crassa ATCC 9276, though not as effective as pyrrolnitrin itself. 2-Carboxy-4-(2-amino-3-bromophenyl)pyrrole (X) is demonstrated to be an intermediate in the biosynthesis of brominated pyrrolnitrin; the biosynthetic pathway to bromo derivatives of pyrrolnitrin is discussed.

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EXTRACTION, CLONING AND PHYSICAL MAPS OF PLASMID DNAs FROM STREPTOMYCES NOURSEI

KATSUO TAKEDA, KAZUE KAWAGUCHI, MASANORI OKANISHI

1983 Volume 36 Issue 12 Pages 1743-1747
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1743

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Three plasmids, pSCY 2, pSCY 3 and pSCY 4, were detected in Streptomyces noursei B3, a producer of cycloheximide and nystatin. pSCY 3 and pSCY 4 had molecular sizes of 15.1 megadaltons (Md) and 3.2 Md, respectively. When covalently closed circular (ccc) DNAs were extracted from the mycelia during the course of cultivation, the yield of ccc DNA extracted per mycelium reached the highest value at the starting point of the exponential growth phase and decreased rapidly during exponential phase; the yield increased gradually in stationary phase. The smallest plasmid, pSCY 4, could not be detected after 42 hours of cultivation. To purify and characterize DNA of the major plasmid pSCY 3, it was cloned into Escherichia coli using pACYC 184 as a vector, and the physical maps of the composite plasmids were constructed.

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MULTIPLE RESISTANCE TO AMINOGLYCOSIDE ANTIBIOTICS IN ACTINOMYCETES

KUNIMOTO HOTTA, ATSUSHI TAKAHASHI, NORIKO SAITO, YOSHIRO OKAMI, HAMAO ...

1983 Volume 36 Issue 12 Pages 1748-1754
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1748

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Actinomycetes were characterized in terms of resistance to 11 different aminoglycoside antibiotics (AGs). Strains freshly isolated in AG containing media showed wide varieties of multiple AG resistance, while the majority of ISP (International Streptomyces Project) cultures and the actinomycete strains isolated in an AG free medium were susceptible to all or most of the AGs tested. Marked characteristics were noted in multiple AG resistance of gray and yellow colored actinomycetes and AG-producing strains. In gray colored isolates, multiple resistance to kanamycin A, dibekacin, ribostamycin, butirosin A, istamycin A and neamine was often observed. Yellow colored isolates having multiple AG resistance were mostly resistant to neamine, ribostamycin and streptomycin and, to a lesser extent, istamycin A, dibekacin and butirosin A. Most of the AG producers tested showed unique multiple AG resistance patterns.

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THE MODE OF ACTION OF A NOVEL 18-MEMBERED MACROLIDE, VIRUSTOMYCIN A (AM-2604 A), ON TRICHOMONAS FOETUS

SATOSHI OMURA, KAZUHIKO OTOGURO, HARUO TANAKA

1983 Volume 36 Issue 12 Pages 1755-1761
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1755

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The mode of action of virustomycin A, a novel 18-membered acrolide, on Trichomonas Foetus was investigated. The antibiotic inhibited the biosynthesis of RNA, DNA and protein in the organism. The inhibition of RNA biosynthesis was the most severe. Virustomycin A repressed the incorporation of [³H]uridine into both acid-soluble and insoluble fractions, whereas actinomycin D inhibited the incorporation of [³H]uridine into acid-insoluble fraction alone. Furthermore, it was found that virustomycin A interfered with nucleotide formation from uridine and adenosine but not with their transport to the cells. On the other hand, the antibiotic did not inhibit the activities of uridine kinase and uracil phosphoribosyltransferase in a cell-free extract from the organism. These data suggest that the antibiotic interferes with the formation of phosphate donor(s)(possibly ATP-forming system)of the organism.

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CELL-FREE SYNTHESIS OF THE DEPSIPEPTIDE BEAUVERICIN

HUGO PEETERS, RAINER ZOCHER, NORBERT MADRY, PETER B. OELRICHS, HORST K ...

1983 Volume 36 Issue 12 Pages 1762-1766
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1762

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The enzymatic formation of the cyclodepsipeptide beauvericin was demonstrated in cell-free extracts from Beauveria bassiana. In analogy to the enniatin synthetase system formation of beauvericin is strictly dependent on the presence of the constituent amino and hydroxy acid, S-adenosylmethionine, and ATP/Mg²⁺. Synthesizing activity could be enriched about 12-fold by fractional ammonium sulfate precipitation. Besides the enniatin synthetase system this represents another example of the cell-free synthesis of a depsipeptide from eucaryotic origin.

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QUINONE MODIFIED DERIVATIVES OF CYANONAPHTHYRIDINOMYCIN

MILTON J. ZMIJEWSKI Jr., MARCIA J. MIKOLAJCZAK

1983 Volume 36 Issue 12 Pages 1767-1769
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1767

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ISOLATION OF A STREPTOMYCES ROCHEI IDIOTROPH REQUIRING β-LYSINE FOR PRODUCTION OF STREPTOTHRICIN

KARTAR SINGH, S. N. SEHGAL, S. RAKHIT, CLAUDE VÉZINA

1983 Volume 36 Issue 12 Pages 1770-1773
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1770

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FR-900318, A NOVEL PENICILLIN WITH β-LACTAMASE INHIBITORY ACTIVITY

MICHIO YAMASHITA, SEIJI HASHIMOTO, MASAMI EZAKI, MORITA IWAMI, TADAAKI ...

1983 Volume 36 Issue 12 Pages 1774-1776
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1774

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NEW ANTIBIOTICS, ALGACIDINS A AND B

TSUYOSHI KIHARA, KIMIE KOBINATA, HIROO KUSAKABE, KIYOSHI ISONO

1983 Volume 36 Issue 12 Pages 1777-1780
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1777

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STRUCTURE OF A NEW ANTIBACTERIAL ANTIBIOTIC, THIOTETROMYCIN

SATOSHI OMURA, AKIRA NAKAGAWA, RIMIKO IWATA, AKIKO HATANO

1983 Volume 36 Issue 12 Pages 1781-1782
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1781

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THE STRUCTURE OF VIRUSTOMYCIN A

SATOSHI OMURA, NOBUTAKA IMAMURA, KIYOIZUMI HINOTOZAWA, KAZUHIKO OTOGUR ...

1983 Volume 36 Issue 12 Pages 1783-1786
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1783

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SYNTHESIS OF ARPHAMENINE A AND EPI-ARPHAMENINE A

HAMAO UMEZAWA, TAKESHI NAKAMURA, SHUNZO FUKATSU, TAKAAKI AOYAGI, KUNIA ...

1983 Volume 36 Issue 12 Pages 1787-1788
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1787

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RELATIONSHIP BETWEEN ANTIBIOTIC RESISTANCE AND ANTIBIOTIC PRODUCTIVITY IN ACTINOMYCETES WHICH PRODUCE AMINOGLYCOSIDE ANTIBIOTICS

KUNIMOTO HOTTA, ATSUSHI TAKAHASHI, YOSHIRO OKAMI, HAMAO UMEZAWA

1983 Volume 36 Issue 12 Pages 1789-1791
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1789

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AMMONIUM ION SUPPRESSES THE BIOSYNTHESIS OF TYLOSIN AGLYCONE BY INTERFERENCE WITH VALINE CATABOLISM IN STREPTOMYCES FRADIAE

SATOSHI OMURA, YOSHITAKE TANAKA, HIROSHI MAMADA, ROKURO MASUMA

1983 Volume 36 Issue 12 Pages 1792-1794
Published: 1983
Released on J-STAGE: April 12, 2006

DOIhttps://doi.org/10.7164/antibiotics.36.1792

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