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Volume 38, Issue 12
Displaying 1-30 of 30 articles from this issue
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FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIESM. A. GOETZ, M. LOPEZ, R. L. MONAGHAN, R. S. L. CHANG, V. J. LOTTI, T. ...1985 Volume 38 Issue 12 Pages 1633-1637
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSThe fermentation and isolation of a new, non-peptide cholecystokinin antagonist, asperlicin, produced by Aspergillus alliaceus is described. The potent and specific interaction of asperlicin with cholecystokinin receptors was shown using in vitro biochemical assays.View full abstractDownload PDF (2076K) -
STRUCTURE ELUCIDATIONJERROLD M. LIESCH, OTTO D. HENSENS, JAMES P. SPRINGER, RAYMOND S. L. C ...1985 Volume 38 Issue 12 Pages 1638-1641
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSAsperlicin (1, C31H29N5O4) is a novel cholecystokinin antagonist produced by Aspergillus alliaceus. The structure of asperlicin has been determined by NMR and mass spectral analysis, and X-ray crystallography.View full abstractDownload PDF (1734K) -
DWARD MEYERS, RAYMOND COOPER, LORETTA DEAN, JANICE H. JOHNSON, DOROTHY ...1985 Volume 38 Issue 12 Pages 1642-1648
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSTwo novel antibiotics, catacandin A and catacandin B, were isolated from the fermentation broth of the bacterium, Lysobacter gummosus, by extraction and adsorption, reverse-phase and gel filtration chromatography. On the basis of their physico-chemical properties, they are acyltetramic acids that are easily distinguishable from others in this class. Catacandin A and catacandin B possess good anticandidal activity.View full abstractDownload PDF (2968K) -
BRIGITTE KUNZE, WERNER KOHL, GERHARD HOFLE, HANS REICHENBACH1985 Volume 38 Issue 12 Pages 1649-1654
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSAngiolam A, a new lactone-lactam antibiotic, was isolated from the culture broth of the myxobacterium Angiococcus disciformis strain An d30. It was active against a few Gram-positive bacteria and mutant strains of Escherichia coli with increased permeability. It appears to interfere with protein synthesis.View full abstractDownload PDF (2784K) -
PRODUCTION, STRUCTURAL DETERMINATION AND BIOLOGICAL ACTIVITIESLUCIEN DAVID, HUMBERTO LEAL AYALA, JEAN-CLAUDE TABET1985 Volume 38 Issue 12 Pages 1655-1663
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSA new polyether antibiotic, abierixin, was found in the mycelium of a culture broth of nigericin-producing Streptomyces albus NRRL B-1865. Abierixin was extracted with organic solvents and purified by column chromatography and HPLC. The structure of abierixin was determined by FAB/MS/MS and CI/MS/MS and 1H and 13C NMR spectrometries. Abierixin exhibited weak antimicrobial and ionophorous activities, low toxicity but good anticoccidial activity. Nigericin biosynthesis from abierixin is discussed.View full abstractDownload PDF (3497K) -
TSUYOSHI TAMAMURA, TSUTOMU SAWA, KUNIO ISSHIKI, TORU MASUDA, YOSHIKO H ...1985 Volume 38 Issue 12 Pages 1664-1669
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSA new antitumor antibiotic, terpentecin was isolated from the culture broth of strain MF730-N6. Strain MF730-N6, isolated from soil, was found to belong to the genus Kitasatosporia. The antibiotic was extracted with chloroform, purified by column chromatography using silica gel and Diaion HP-20 successively, and finally purified by high performance reverse-phase thin layer chromatography. The molecular formula of terpentecin was determined to be C20H28O6 (molecular weight, 364). The antibiotic inhibited the growth of Gram-positive and Gram-negative bacteria, and prolonged the survival period of mice bearing leukemia L-1210, P388 and Ehrlich ascites carcinoma.View full abstractDownload PDF (2593K) -
TAXONOMY OF PRODUCING ORGANISM, ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITIESYUTAKA KIKUCHI, MITSURU NIWANO, NOBUHIRO YAJIMA, GOTO NAKAMURA, NOBUO ...1985 Volume 38 Issue 12 Pages 1670-1676
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSA novel macromolecular antibiotic SN-07 was obtained from the cultural supernatant of Actinomadura roseoviolacea var. miuraeusis nov. var. The antibiotic was soluble in water, had a molecular weight of 18, 000-22, 000 daltons in 50mM Tris-HCl buffer, pH 7.0, containing 2.0 M KCl as compared with authentic proteins. Its major constituents were nucleic acids. The substance had antibacterial activity against Gram-positive bacteria. It was also effective against lymphocytic leukemia P388 in vivo.View full abstractDownload PDF (3201K) -
SHINJI FUNAYAMA, KENJI OKADA, KAZUYO IWASAKI, KANKI KOMIYAMA, IWAO UME ...1985 Volume 38 Issue 12 Pages 1677-1683
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSThe structures of novel antibiotics, trienomycins A, B and C produced by Streptamyces sp. No. 83-16, have been determined on the basis of their spectroscopical and chemical properties. Trienomycins are unique ansamycin antibiotics with a triene and an 1, 3, 5-trisubstituted benzene moieties in the molecule. The antibiotics possess potent cytocidal activity against HeLa S3 cells at concentrations of 0.005 (trienomycin A), 0.1 (trienomycin C) and 0.2μg/ml (trienomycin B) (IC50 value), respectively. However, trienomycins showed no antimicrobial activity against the bacteria, fungi and yeasts examined with the exception of weak activity versus Piricularia oryzae at a concentration of 1, 000μg/ml.View full abstractDownload PDF (3372K) -
SPECTROSCOPIC CHARACTERIZATION AND X-RAY ANALYSIS OF A BROMO DERIVATIVEHERMANN UHR, AXEL ZEECK, WILLIAM CLEGG, ERNST EGERT, HERMANN FUHRER, H ...1985 Volume 38 Issue 12 Pages 1684-1690
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSAcetomycin (1a), known since 1958, has been further characterized by NMR and CD spectra. The β-acetyl side chain of 1a is reduced selectively by sodium cyanoborohydride yielding the diastereomeric alcohols 2a and 3a, which were esterified to the crystalline bromoacetates 2c and 3c. The structure and absolute configuration of 3c was determined by X-ray analysis. From these data the absolute configuration of 1a followed as 3S, 4S, 5R.View full abstractDownload PDF (3491K) -
RAY S. DEWEY, BYRON H. ARISON, JOHN HANNAH, DAVID H. SHIH, GEORG ALBER ...1985 Volume 38 Issue 12 Pages 1691-1698
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSThe antibiotic efrotomycin (I), C59H88N2O20, was isolated from cultures of Nocardia lactamdurans as an amorphous yellow powder. Mass spectral and NMR analyses show that the compound is a glycoside of the known antibiotic aurodox (II), C44H62N2O12. Ozonolysis and hydrolysis of I produced the disaccharide V, 6-deoxy-4-O-(6-deoxy-2, 4-di-O-methyl-α-L-mannopyranosyl)-3-O-methyl-β-D-allopyranose. This disaccharide is attached to the 4-hydroxyl group of the hexahydropyran substructure of aurodox via a β-linkage to C-1 of the allose.View full abstractDownload PDF (3392K) -
A. ASZALOS, A. BAX, N. BURLINSON, P. ROLLER, C. MCNEAL1985 Volume 38 Issue 12 Pages 1699-1713
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSTwo polyene antibiotics, nystatin and amphotericin A, were compared by physicochemical and microbiological methods. The two antibiotics were found to have the same molecular weight, 926, by plasma desorption and electron-impact MS. However, 13C NMR spectrometry and HPLC studies indicated that the two molecules are different. The 200 MHz NMR studies indicated a chemical environment of 24 carbons of amphotericin A identical with that of the carbons of amphotericin B and nystatin. The structure of amphotericin A is identical with that of amphotericin B, except that there is a single bond between carbons 28 and 29 instead of a double bond, as shown by two-dimensional NMR studies.View full abstractDownload PDF (5395K) -
VÊRA PRIKRYLOVÁ, HELENA LIPAVSKÁ, JOSEF V. JIZBA, ...1985 Volume 38 Issue 12 Pages 1714-1718
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSSynthesis and antibacterial activity of a number of 7-O-epoxyalkyl derivatives of daunomycinone prepared from 7-O-alkenyl derivatives of daunomycinone are described along with their inhibitory effect on leukemia P 388 cells.View full abstractDownload PDF (2433K) -
N-FUNCTIONALIZED ACYLKANAMYCIN A DERIVATIVES">III. SYNTHESIS AND IN VITRO ANTIVIRAL ACTIVITY OF 1-N-HIGHER-ACYL-3"-N-FUNCTIONALIZED ACYLKANAMYCIN A DERIVATIVESKEIJI MATSUDA, NOBUYOSHI YASUDA, HIDEO TSUTSUMI, TAKAO TAKAYA1985 Volume 38 Issue 12 Pages 1719-1737
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSThe synthesis and antiviral activity of 1-N-palmitoyl- or 1-N-(3-hydroxytetradecanoyl)-kanamycin A derivatives (7, 8) having various type of acyl substituents at the N-3" position were investigated. The structure-activity relationships between the antiviral activity and the substituent at the N-3" position is described. In this series, 3"-N-acetyl-1-N-palmitoylkanamycin A (7c) showed the excellent antiviral activity against HSV-I and influenza virus. Further, we examined the synthesis and the antiviral activity of 3"-N-glycylkanamycin A derivatives (9) having a higher-acyl group at the N-1 position. The 3"-N-glycyl-1-N-pentadecanoylkanamycin A (9a) also exhibited excellent antiviral activity.View full abstractDownload PDF (7815K) -
IX. SYNTHESIS AND BIOLOGICAL ACTIVITY OF A NEW ORALLY ACTIVE CEPHALOSPORIN, CEFIXIME (FK027)HIDEAKI YAMANAKA, TOSHIYUKI CHIBA, KOHJI KAWABATA, HISASHI TAKASUGI, T ...1985 Volume 38 Issue 12 Pages 1738-1751
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSThe synthesis and some biological properties of 7β-[(Z)-2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino) acetamido]-3-vinyl-3-cephem-4-carboxylic acid (3, FK027)** are described. Diphenylmethyl 7-amino-3-vinyl-3-cephem-4-carboxylate hydrochloride (8), the cephem precursor to FK027 was prepared from 7-aminocephalosporanic acid (7-ACA) by two parallel routes differing primarily in the protection of the 7-amino group. Compound 8 was alternatively prepared from deacetylcephalosporin C sodium salt (DCCNa) with improved yields. Two pathways for the conversion of 8 to FK027 are provided. The new orally active cephalosporin, FK027, possesses a widely expanded antimicrobial activity and high stability to β-lactamases.View full abstractDownload PDF (13537K) -
BRUNO CAVALLERI, MARCO TURCONI, ROSETTA PALLANZA1985 Volume 38 Issue 12 Pages 1752-1760
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSA series of derivatives has been prepared from the antibiotic thermorubin, some of which show a substantial modification of the original structure. The antibacterial activities are reported.View full abstractDownload PDF (7547K) -
SOON-YOUNG PAIK, MASANORI SUGIYAMA, RYOSAKU NOMI1985 Volume 38 Issue 12 Pages 1761-1766
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSPuromycin 2"-N-acetyltransferase was isolated from cell extracts of puromycin-producing Streptomyces alboniger KCC S-0309 by ammonium sulfate fractionation, heat treatment to eliminate contaminant proteins and chromatography on DEAE-Toyopearl 650S. After PAGE (polyacrylamide gel electrophoresis) of the final fraction, a single protein band corresponding to puromycin 2"-N-acetyltransferase was detected. The molecular weight of the enzyme determined by SDS-PAGE and Sephadex G-150 chromatography was about 21, 000 and 85, 000, respectively, suggesting that the enzyme consisted of four subunits. The isoelectric point and the optimum pH for reaction were 6.2 and 7.7, respectively. The Km values for puromycin and acetyl coenzyme A were 40 μM and 67 μM, respectively. The enzyme was thermostable up to 70°C for 12 minutes. It was shown, by using an in vitro protein synthesizing system from a puromycin-susceptible organism S. flavotricini subsp. pseudochromogenes V-13-1, that the isolated puromycin 2"-N-acetyltransferase could protect polyphenylalanine synthesis from inhibition by puromycin.View full abstractDownload PDF (5971K) -
SHIN-ICHIRO TAKAHASHI, HISANORI KATO, TAI-ICHIRO SEKI, TADASHI NOGUCHI ...1985 Volume 38 Issue 12 Pages 1767-1773
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSBestatin, a microbial aminopeptidase inhibitor, inhibited insulin- or epidermal growth factor-induced DNA synthesis and cell proliferation in primary cultured hepatocytes of rats. The aminopeptidase inhibitor also affected the growth of FM3A or LOBN cells of mice, when it is included in the culture media at the concentration of 0.5 mg/ml. These results suggest the important role of the bestatin-sensitive aminopeptidase(s) in the process of DNA synthesis and proliferation of animal cells.View full abstractDownload PDF (10405K) -
IKUMI TAMAI, TETSUYTA TERASAKI, AKIRA TSUJI1985 Volume 38 Issue 12 Pages 1774-1780
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSThe inhibition effect of several β-lactam antibiotics on the uptake of [14C] to ibenzylpenicillin (PCG) insolated rat hepatocytes was studied. Monobasic, β-lactam antibiotics such as apalcillin, cloxacillin, nafcillin, piperacillin, cefmetazole, cefoperazone, cefpiramide and cephalothin significantly inhibited the uptake of PCG, while amphoteric β-lactam antibiotics such as amoxicillin, ciclacillin, cephradine, cephalexin and cephaloridine had a slight inhibitory effect on the uptake of PCG. Five monobasic compounds of these antibiotics used (apalcillin, nafcillin, piperacillin, cefmetazole and cefoperazone) which have a tendency to be excreted into bile to a large extent, inhibited the initial uptake rate of PCG in a fully competitive fashion according to the Line-weaver-Burk plots and the corresponding modified Inui-Christensen plots. Thus, it was concluded that almost all β-lactam antibiotics have a common carrier system responsible for their uptake into isolated rat hepatocytes, but it is still uncertain whether or not amphoteric; β-lactam antibiotics have another specific transport system.View full abstractDownload PDF (3520K) -
IV. ACTIVATION OF MOUSE MACROPHAGESYUJI WATANABE, SHUICHI TAWARA, YASUHIRO MINE, HIROYUKI KIKUCHI, SACHIK ...1985 Volume 38 Issue 12 Pages 1781-1787
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSWe investigated the effects of the immunoactive peptides, FK 156 and FK 565, on functions of mouse macrophages. FK 156 and FK 565 given parenterally or orally to mice enhanced spreading of peritoneal macrophages, phagocytosis of latex particles and intracellular killing of bacteria by peritoneal macrophages. FK 156 and FK 565 also enhanced the production of superoxide anion and lysosomal enzyme activities of macrophages. The peptides also activated mouse spleen macrophages, and the kinetics of this activation differed from that of the peritoneal macrophages. In addition, both drugs directly enhanced the production of superoxide anion by mouse peritoneal macrophages treated in vitro and enhanced the functions of peritoneal macrophages of athymic nude mice. Both these phenomena suggest that direct activation might be one of the mechanisms of macrophage activation by the peptides.View full abstractDownload PDF (3323K) -
S. K. ARORA1985 Volume 38 Issue 12 Pages 1788-1791
Published: 1985
Released on J-STAGE: April 19, 2006
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C. LÜBBE, S. WOLFE, J. E. SHIELDS, S. W. QUEENER, N. NEUSS, A. L. ...1985 Volume 38 Issue 12 Pages 1792-1794
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSDownload PDF (1556K) -
KIYOSHI HIRASAWA, MASARU ICHIHARA, MASANORI OKANISHI1985 Volume 38 Issue 12 Pages 1795-1798
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSDownload PDF (1565K) -
A. VIGEVANI, M. BALLABIO, B. GIOIA, L. MARSILI, S. VIOGLIO, G. FRANCES ...1985 Volume 38 Issue 12 Pages 1799-1802
Published: 1985
Released on J-STAGE: April 19, 2006
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YOKO IKEDA, SHUICHI GOMI, KAZUTERU YOKOSE, HIROSHI NAGANAWA, TAKAKO IK ...1985 Volume 38 Issue 12 Pages 1803-1805
Published: 1985
Released on J-STAGE: April 19, 2006
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TOSHIO TAKATSU, HIROSHI NAKAYAMA, AKIRA SHIMAZU, KEIKO FURIHATA, KEIJI ...1985 Volume 38 Issue 12 Pages 1806-1809
Published: 1985
Released on J-STAGE: April 19, 2006
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YUICHI ABE, HIROSHI NAKAYAMA, AKIRA SHIMAZU, KEIKO FURIHATA, KEIJI IKE ...1985 Volume 38 Issue 12 Pages 1810-1812
Published: 1985
Released on J-STAGE: April 19, 2006
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HAMAO UMEZAWA, TAKAAKI AOYAGI, KEIJI OGAWA, TAMAMI OBATA, HIRONOBU IIN ...1985 Volume 38 Issue 12 Pages 1813-1815
Published: 1985
Released on J-STAGE: April 19, 2006
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YUKIHIKO KAMEDA, NAOKI ASANO, MASAYOSHI TAKEUCHI, TAKUJI YAMAGUCHI, KA ...1985 Volume 38 Issue 12 Pages 1816-1818
Published: 1985
Released on J-STAGE: April 19, 2006
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KUNIO ISSHIKI, TSUYOSHI TAMAMURA, YOSHIKAZU TAKAHASHI, TSUTOMU SAWA, H ...1985 Volume 38 Issue 12 Pages 1819-1821
Published: 1985
Released on J-STAGE: April 19, 2006
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MARIA VIKMON, ÁGNES STADLER-SZÖKE, JÓZSEF SZEJTLI1985 Volume 38 Issue 12 Pages 1822-1824
Published: 1985
Released on J-STAGE: April 19, 2006
JOURNAL FREE ACCESSDownload PDF (1589K)
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