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ISOLATION OF SQ28, 504 AND SQ28, 546 FROM CHROMOBACTERIUM VIOLACEUM
RAYMOND COOPER, J. SCOTT WELLS, RICHARD B. SYKES
1985 年 38 巻 4 号 p.
449-454
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
Two novel compounds, SQ28, 504 and SQ28, 546 are produced by
Chromobacterium violaceum. These compounds enhance the antibacterial activity of β-lactam antibiotics against Gram-negative organisms. Both SQ28, 504 and SQ28, 546 induce morphological changes in the presence of β-lactam antibiotics. Only SQ28, 546 has weak antimicrobial activity against several Gram-negative organisms.
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I. FERMENTATION, ISOLATION AND CHARACTERIZATION
TADAAKI KOMORI, MICHIO YAMASHITA, YASUHISA TSURUMI, MASANOBU KOHSAKA
1985 年 38 巻 4 号 p.
455-459
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
Chaetiacandin, a new anti-yeast antibiotic structurally related to papulacandin, was isolated from a culture of
Monochaetia dimorphospora. The fermentation, isolation, and physicochemical and biological properties are reported. The molecular formula of this compound was determined as C
43H
60O
16.
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TAXONOMY, FERMENTATION AND BIOLOGICAL ACTIVITY
J. B. TUNAC, B. D. GRAHAM, W. E. DOBSON, M. D. LENZINI
1985 年 38 巻 4 号 p.
460-465
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
The novel, broad-spectrum antitumor antibiotics, CI-940 (PD 114, 720) and PD 114, 721 are components of bioactive compounds produced by a novel actinomycete (ATCC 39366). The organism is unique in that whole cell analysis revealed LL-diaminopimelic acid and major amounts of arabinose. These new antibiotics exhibit potent antitumor activity
in vitro and
in vivo versus an array of tumors and possess strong antibacterial and antifungal activity. The above antibiotics are produced in 7, 570-liter fermentors at yields of 5-8μg/ml.
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TERUJI TSUJI, HISAO SATOH, MASAYUKI NARISADA, YOSHIO HAMASHIMA, TADASH ...
1985 年 38 巻 4 号 p.
466-476
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
The synthesis and
in vitro activity of 7β-difluoromethylthioacetamido-7α-methoxy-3-[[1-(hydroxyethyl)-1
H-tetrazol-5-yl]thiomethyl]-1-oxa-3-cephem-4-carboxylic acid sodium salt, 6315-S, are described. 6315-S shows good antibacterial activity against Gram-positive and Gram-negative bacteria, being especially highly active against clinical isolates of
Staphylococcus aureus resistant to either ampicillin or methicillin. The structure-activity relationship of related 1-oxa and 1-thia cephems is also presented.
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SHUICHI SAKAMOTO, TSUTOMU TSUCHIYA, AKIHIRO TANAKA, SUMIO UMEZAWA, MAS ...
1985 年 38 巻 4 号 p.
477-484
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
23-Amino-4', 23-dideoxymycaminosyl tylonolide diethyl acetal (
5) has been prepared from 4', 23-dideoxy-23-iodomycaminosyl tylonolide diethyl acetal (
3) by treatment with sodium azide followed by selective reduction of the resulting azide (
4). 23-Acylamino-23-deoxy (
6-8) and 23-deoxy-23-urethane-type compounds (
12-15) were further prepared. Treatment of the 23-alkylamino-4', 23-dideoxymycaminosyl tylonolides (
9, 10) with chloroformates gave 23-
N-alkyl-23-deoxy-23-urethane-type compounds (
16-21, 29, 30). 23-
N-Alkyl-23-deoxy-23-(2-hydroxyethylamino and 2-methoxyethylamino)-4', 23-dideoxymycaminosyl tylonolides (
22-25, 27, 28) were prepared from
3 and the corresponding amines. Antibacterial activities and toxicities (for
23 and
27) of these compounds are described.
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PATRICK M. KELLY, KAREN A. NABINGER
1985 年 38 巻 4 号 p.
485-489
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
A method has been developed for the separation of the filipin complex components by gradient-elution high performance liquid chromatography (HPLC). The elution order for the major filipin components (filipins I-IV) was established by first isolating the component fractions by thin-layer chromatography. Each component fraction was then subjected to gradient HPLC. The order of elution for the major filipin components was from first to last : III, IV, II and I. The unexpected reversal in the elution order for filipin III and IV may be evidence that the two filipins are stereoisomeric at the C-1' position. Finally, gradient elution HPLC was used to compare various preparations of filipin. In addition, the technique has been applied to other preparations of polyene antibiotics which have structures similar to that of filipin.
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MAKOTO MORIMOTO, RYOJI IMAI
1985 年 38 巻 4 号 p.
490-495
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
Echinosporin isolated from a
Streptomyces culture showed antitumor activity against rodent tumor models such as leukemia P388, P388/VCR, and fibrosarcoma Meth 1. It was marginally active against melanoma B16 and sarcoma 180. It was not active against Lewis lung carcinoma and xenograft MX-1. It inhibited the colony formation of HeLa S
3 cells with a wide shoulder at low dose ranges. DNA, RNA, and protein synthesis were inhibited by echinosporin. It depressed WBC with nadir on day 3, but the recovery to the normal level after echinosporin injection was more rapid than that after mitomycin C.
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HIROSHI SAKAMOTO, TOSHIHARU HIROSE, YASUHIRO MINE
1985 年 38 巻 4 号 p.
496-504
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
The pharmacokinetics of FK027, a new oral cephalosporin, were investigated in rats and dogs and compared with those of cefaclor, cephalexin and amoxicillin. Upon oral administration to either rats or dogs, FK027 produced higher and more sustained serum levels than the reference drugs, hence a longer half-life. After both oral and intravenous administration, the half-life of FK027 in dogs was approximately three fold that in rats. Although the concentrations of FK027 in rat kidney, liver and spleen were lower than those of cephalexin and amoxicillin, they were sustained similarly to the serum levels. The 24-hour urinary and biliary recovery rates of FK027 in rats after oral dosing with 100 mg/kg were 34.1 and 21.9 %, respectively. The urinary excretion of FK027 was significantly lower than that of the reference drugs, however, the biliary excretion was higher. In dogs, 23.4 and 0.2% of the given dose of 40 mg/kg of FK027 was excreted in the 24-hour urine and bile, respectively. Bioavailability of FK027 after oral dosing was 38% in rats and 47% in dogs, as calculated from intravenous data. Binding of FK027 to serum protein in all species was the highest of the test drugs : 63% for human, 93% for dog, 61% for rat serum.
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TADASHI MABUCHI, KAZUHIKO WAKABAYASHI
1985 年 38 巻 4 号 p.
505-512
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
An
Escherichia coli-yeast shuttle vector pOL 221 is described, which consists of pBR 322 and a yeast mitochondrial fragment. The mitochondrial insert in pOL 221 possessed a mitochondrial autonomously replicating sequence (
ARS) and a single
Sst II site. The
ARS function of pOL 221 was demonstrated by insertion of
LEU2 gene into pOL 221 (giving pOL 2211) followed by the transformation of leu
- yeast cells. By use of this vector, chimeric plasmids pOL 37 and pOL 379 (a derivative of pOL 37 inserted with
LEU2 gene), carrying the yeast mitochondrial
oli-1 gene were constructed. Marked instability was observed on the maintenance of pOL 37 in
E. coli under non-selective conditions. pOL 37 can, however, be maintained in
E. coli in the presence of tetracycline. pOL 2211, pOL 379 and other pOL plasmids showed mitotic instability in yeast. Transformants of oligomycin sensitive yeast cells with pOL 37 and pOL 379 did not show oligomycin resistance. The absence of recombination between the cloned mitochondrial gene and the host mitochondrial gene is discussed.
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R. W. RICKARDS, J.-P. WU
1985 年 38 巻 4 号 p.
513-515
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
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A. J. HERLT, R. W. RICKARDS, J.-P. WU
1985 年 38 巻 4 号 p.
516-518
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
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YOSHIO INOUYE, NORIKO MANABE, HIROYUKI MUKAI, SHOSHIRO NAKAMURA, TAKAY ...
1985 年 38 巻 4 号 p.
519-521
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
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VIII. CHEMICAL DEGRADATION AND ABSOLUTE CONFIGURATION OF MYCINAMICINS
KENJI KINOSHITAS, HUZOS ATOI, MITSUO HAYASHI, KEN-ICHI HARADA, MAKOTO ...
1985 年 38 巻 4 号 p.
522-526
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
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M. V. PATEL
1985 年 38 巻 4 号 p.
527-529
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
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M. S. PUAR, H. MUNAYYER, V. HEGDE, B. K. LEE, J. A. WAITZ
1985 年 38 巻 4 号 p.
530-532
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
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TETSUO HAMAMOTO, TAKESHI UOZUMI, TERUHIKO BEPPU
1985 年 38 巻 4 号 p.
533-535
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
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LEONE DALL'ASTA, ANDREA COMINI, EUGENIO GAREGNANI, MARIA ANTONIETTA BE ...
1985 年 38 巻 4 号 p.
536-537
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
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JUN'ICHI SHOJI, RYUZI SAKAZAKI, TOSHIYUKI KATO, YOSHIHIRO TERUI, KOICH ...
1985 年 38 巻 4 号 p.
538-540
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
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GEORGE A. ELLESTAD, JOHN C. JAMES, GEORGE O. MORTON, MARSHALL M. SIEGE ...
1985 年 38 巻 4 号 p.
541-543
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
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II. STRUCTURE DETERMINATION
TADAAKI KOMORI, YOSHIKUNI ITOH
1985 年 38 巻 4 号 p.
544-546
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
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I. SYNTHESIS AND IN VITRO ANTIVIRAL ACTIVITY OF NEW KANAMYCIN A DERIVATIVES
KEIJI MATSUDA, NOBUYOSHI YASUDA, HIDEO TSUTSUMI, TAKAO TAKAYA
1985 年 38 巻 4 号 p.
547-549
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー
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MICHAEL J. DRIVER, JOHN LOWTHER, ANDREW W. TAYLOR
1985 年 38 巻 4 号 p.
550-553
発行日: 1985年
公開日: 2006/04/19
ジャーナル
フリー