巻号一覧
38 巻, 5 号
選択された号の論文の22件中1～22を表示しています
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I. TAXONOMY, PRODUCTION AND BIOLOGICAL ACTIVITYMARCIA C. SHEARER, PAUL ACTOR, BETTY ANNE BOWIE, SARAH F. GRAPPEL, CLA ...1985 年 38 巻 5 号 p. 555-560
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーA new species of a new genus of the Actinomycetales was discovered, Kibdelosporangium aridum. This strain produces a new family of glycopeptide antibiotics designated aridicins, that contain an unusual glycolipid constituent. They inhibit Gram-positive bacteria, including staphylococci, enterococci and Clostridium sp.抄録全体を表示PDF形式でダウンロード (3098K) -
II. ISOLATION AND CHARACTERIZATIONROBERT D. SITRIN, GEORGE W. CHAN, JOHN J. DINGERDISSEN, WALTER HOLL, J ...1985 年 38 巻 5 号 p. 561-571
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーA new antibacterial antibiotic complex, aridicin, was produced by a new genus, Kibdelosporangium aridum (SK&F-AAD-216). The individual factors, aridicins A, B and C, were isolated from the fermentation broth by an Amberlite XAD-7 resin extraction and purified by preparative reversed phase HPLC. The aridicins were found to be novel members of the glycopeptide class of antibiotics as exemplified by ristocetin and vancomycin, based on chemical and spectroscopic data, their molecular weights as determined by FAB mass spectrometry (1, 786, 1, 800 and 1, 814), the detection of actinoidinic acid in their acid hydrolysates, and detailed TLC and HPLC comparisons with representative members of this class.抄録全体を表示PDF形式でダウンロード (5200K) -
D. L. KERN, G. C. HOKANSON, J. C. FRENCH, N. KENT DALLEY1985 年 38 巻 5 号 p. 572-574
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーA new antibiotic, PD 113, 876, was isolated from the culture broth of a Streptomyces sp. and was shown by X-ray diffraction analysis to be the N-7 oxide of guanine. This novel antimetabolite is very active in vivo against L1210 lymphocytic leukemia.抄録全体を表示PDF形式でダウンロード (1489K) -
H. A. KIRST, D. E. DORMAN, J. L. OCCOLOWITZ, N. D. JONES, J. W. PASCHA ...1985 年 38 巻 5 号 p. 575-586
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーThe structure of the novel nucleoside antibiotic A201A has been determined by a combination of chemical and spectroscopic methods. It is composed of 6-dimethylaminopurine, 3-amino-3-deoxyribose, p-hydroxy-α-methylcinnamic acid, a novel unsaturated hexofuranose and 3, 4-di-O-methylrhamnose. Structures have also been assigned to several related minor factors simultaneously isolated from the fermentation broth. These unique nucleosides have very interesting similarities and differences in structure with the known antibiotics puromycin and hygromycin A.抄録全体を表示PDF形式でダウンロード (5749K) -
I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIESHIROSHI OGAWARA, KEIJIRO UCHINO, TETSU AKIYAMA, SHUN-ICHI WATANABE1985 年 38 巻 5 号 p. 587-591
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーNew 5'-nucleotidase inhibitors named melanocidins A and B were produced by Nocardioides sp. 1681 J. They were isolated from fermentation broth by trichloroacetic acid extraction, ethanol precipitation and CM-cellulose and DEAE-cellulose column chromatography. They inhibited 5'-nucleotidase activity from snake venom but not from rat liver membrane at 200 μg/ml. They also show antitumor activity against melanoma B16.抄録全体を表示PDF形式でダウンロード (1985K) -
II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATIONKEIJIRO UCHINO, HIROSHI OGAWARA, TETSU AKIYAMA, AKIRA FUKUCHI, SHOJI S ...1985 年 38 巻 5 号 p. 592-598
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーNew 5'-nucleotidase inhibitors named melanocidins A and B were isolated from a fermentation broth of Nocardioides sp. The molecular weights estimated by gel filtration were over 1, 000, 000. By the combination of chemical and physico-chemical analyses, we revealed their chemical structures.抄録全体を表示PDF形式でダウンロード (3208K) -
AKIRAE NDO, HIROSHI TAKESHIMA, KENJI KUWABARA1985 年 38 巻 5 号 p. 599-604
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーFour active metabolites that specifically inhibit acetyl CoA carboxylase, the late-limiting enzyme in fatty acid biosynthesis, have been isolated from a strain of Gongronella butleri mating type (+). Their chemical structures were determined to be octyl pentanedioic acid, 9-decenyl-1-pentenedioic acid, decanyl-1-pentenedioic acid, decanyl-2-pentenedioic acid, respectively. These compounds inhibited rat liver acetyl CoA carboxylase 50% at a concentration of 30-55 μg/ml.抄録全体を表示PDF形式でダウンロード (2661K) -
HARUYUKI YAMASHITA, SAEKO TSUBOKAWA, AKIRA ENDO1985 年 38 巻 5 号 p. 605-609
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーThe Basidiomycete Schizophyllum commune was found to transform compactin (ML-236B) to 8a-hydroxycompactin. This compound was isolated by solvent extraction and column chromatography, and its structure was determined by a combination of IR, UV, 1H NMR and 13C NMR spectroscopy . Monacolin K was also converted to the corresponding hydroxylated analogue. Data on the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and sterol biosynthesis in vitro are presented for these hydroxylated compounds.抄録全体を表示PDF形式でダウンロード (2256K) -
MITSUAKI HTANI, FUMIHIKO WATANABE, MASAYUKI NARISADA1985 年 38 巻 5 号 p. 610-621
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーA synthesis of several carbapenem antibiotics including 9-methoxythienamycin is described. The final deprotection of C-3 esters was accomplished by a novel procedure using aluminum trichloride under a very mild condition. The antibacterial activity against Gram-positive and Gram-negative bacteria is shown.抄録全体を表示PDF形式でダウンロード (6619K) -
III. ENZYMOLOGICAL CHARACTERIZATION OF THE L-AMINO ACID ACYLASE ACTIVITY OF A933 ACYLASEKATSURO KUBO, TOMOYUKI ISHIKURA, YASUO FUKAGAWA1985 年 38 巻 5 号 p. 622-630
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーA933 acylase, which is involved in exchange of the pantothenyl substituent of OA-6129 carbapenems with acetyl CoA, was characterized as an L-amino acid acylase with a molecular weight of 100, 000 (±8, 000) and a pI value of 5.1. The highest L-amino acid acylase activity of A933 acylase was observed at 37°C and pH 7-7.5 for N-chloroacetyl-L-phenylalanine. Unlike other amino acid acylases, A933 acylase was severely inhibited by cobalt ions and p-chloromercuribenzoate. The acylase also showed peptidase activity with some di- and tri-peptides. A protein fraction with A933 L-amino acid acylase activity from blocked mutant 1501 lacked OA-6129A-depantothenylating activity.抄録全体を表示PDF形式でダウンロード (3786K) -
IV. BIOSYNTHESISTORU OKUDA, TAMOTSU FURUMAI1985 年 38 巻 5 号 p. 631-635
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーBioconversion experiments using washed mycelia of Penicillium aculeatum NR 5165 and NR 6216 revealed that penitricin (Ro 09-0804, hydroxymethylcyclopropenone) was biosynthesized from trans-2-butene-1, 4-diol via 4-hydroxycrotonaldehyde.抄録全体を表示PDF形式でダウンロード (2028K) -
SUEHARU HORINOUCHI, MAKOTO NISHIYAMA, HIDEKI SUZUKI, YOICHI KUMADA, TE ...1985 年 38 巻 5 号 p. 636-641
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーBy cleavage with restriction endonucleases and cloning the resultant fragments, the A-factor determinant cloned from streptomycin-producing Streptomyces bikiniensis (HORINOUCHI et al., J. Bacteriol. 158: 481-487, 1984) was narrowed down to a 1.1-kilobase (kb) fragment. A hybrid multicopy plasmid (pAFB15) carrying the 1.1-kb fragment conferred A-factor production in a large quantity to A-factor-deficient mutants of S. bikiniensis and Streptomyces griseus as well as afsA mutants of Streptomyces coelicolor A3(2). A transcriptional control signal in the 1.1-kb fragment was identified by using a promoter-probe vector pARC 1. Plasmid pAFB15 also caused A-factor production with a marked gene dosage effect in four different Streptomyces strains which originally had no ability to produce A-factor and no DNA sequence homologous to the S. bikiniensi A-factor determinant, suggesting that precursors of A-factor are common metabolites in streptomycetes and that acquisition of only a single key enzyme encoded by the 1.1-kb fragment is sufficient for Streptomyces strains to synthesize A-factor.抄録全体を表示PDF形式でダウンロード (3376K) -
INHIBITION OF TUMOR GROWTH AND METASTASIS, IMMUNOSTIMULATION, AND POTENTIATION OF 1-β-D-ARABINOFURANOSYLCYTOSINEBAO DING YUAN, RONG TSUN WU, ISAO SATO, TAKAYOSHI OKABE, HIDEO SUZUKI, ...1985 年 38 巻 5 号 p. 642-648
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーCadeguomycin retarded growth of sc solid IMC carcinoma in CDF1 mice, and pulmonary metastasis of Lewis lung carcinoma in C57BL/6 mice. The antibiotic enhanced phagocytic activity of murine peritoneal macrophages and IL-1 production by P388D1 cells. Delayed type hypersensitivity was stimulated and interferon was induced by the drug. The results suggest that cadeguomycin inhibits tumor growth and metastasis in association with modification of the immune system. The cytotoxicity of arabinosylcytosine to K562 and YAC-1 cells was markedly enhanced by cadeguomycin in culture. The combined administration of arabinosylcytosine and cadeguomycin displayed potentiation in the inhibition of growth of ip-implanted P388 leukemia and metastasis of sc-implanted P388 leukemia to the regional lymph nodes. Cadeguomycin showed low toxicity for mice.抄録全体を表示PDF形式でダウンロード (3141K) -
KUNITOMO WATANABE, KAKUYO SAWA, MIDORI BUNAI, KAZUE UENO1985 年 38 巻 5 号 p. 649-660
発行日: 1985年
公開日: 2006/04/19
ジャーナル フリーThe antibacterial activity of cefminox (CMNX) against anaerobic bacteria was studied in vitro. The results are as follows : 1. CMNX exerted antibacterial activity against a wide range of anaerobes, excluding Clostridium innocuum. The antibacterial activity of CMNX against Bacteroides fragilis was comparable to that of latamoxef and superior to cefoxitin, but CMNX's activity against anaerobic cocci was slightly inferior to cefoxitin's ; 2. A comparison of the MICs and MBCs of CMNX indicated that this drug exerts a complete bactericidal effect at a concentration which inhibits the growth of bacteria ; 3. CMNX was found to be stable to the β-lactamases produced by B. fragilis; 4. CMNX exerted an antibacterial activity against C. difficile.抄録全体を表示PDF形式でダウンロード (3971K) -
D. NEGRE, E. ROBERT, E. ANDRIEUX, A. J. COZZONE1985 年 38 巻 5 号 p. 661-664
発行日: 1985年
公開日: 2006/04/19
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MASAKAZU URAMOTO, YIN-CHU SHEN, NAOMI TAKIZAWA, HIROO KUSAKABE, KIYOSH ...1985 年 38 巻 5 号 p. 665-668
発行日: 1985年
公開日: 2006/04/19
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MITUO OGURA, HIROSHI NAKAYAMA, KAZUO FURIHATA, AKIRA SHIMAZU, HARUO SE ...1985 年 38 巻 5 号 p. 669-673
発行日: 1985年
公開日: 2006/04/19
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SATOSHI OMURA, AKIRA NAKAGAWA, NOBUTAKA IMAMURA, KATSUHIKO KUSHIDA, CH ...1985 年 38 巻 5 号 p. 674-676
発行日: 1985年
公開日: 2006/04/19
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LOUISE H. FOLEY, MANFRED WEIGELE1985 年 38 巻 5 号 p. 677-679
発行日: 1985年
公開日: 2006/04/19
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KUNIAKI TATSUTA, KOHJI AKIMOTO, MASAHIKOA NNAKA, YUTAKA OHNO, MITSUHIR ...1985 年 38 巻 5 号 p. 680-682
発行日: 1985年
公開日: 2006/04/19
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TAK-MING CHEUNG, DEREK HORTON, WALDEMAR PRIEBE, WILLIAM R. TURNER, WOL ...1985 年 38 巻 5 号 p. 683-686
発行日: 1985年
公開日: 2006/04/19
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6. PRODUCTION OF N-ACETYL- DEMETHYLPHOSPHINOTHRICIN AND N-ACETYLBIALAPHOS BY BLOCKED MUTANTS OF STREPTOMYCES HYGROSCOPICUS SF-1293 AND THEIR ROLES IN THE BIOSYNTHESIS OF BIALAPHOSSATOSHI IMAI, HARUO SETO, TORU SASAKI, TAKASHI TSURUOKA, HIROSHI OGAWA ...1985 年 38 巻 5 号 p. 687-690
発行日: 1985年
公開日: 2006/04/19
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