巻号一覧
40 巻, 10 号
選択された号の論文の20件中1～20を表示しています
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I. TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITYCHRISTOPHER M. M. FRANCO, JULIA N. GANDHI, SUGATA CHATTERJEE, BIMAL N. ...1987 年 40 巻 10 号 p. 1361-1367
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーA new macrolide antibiotic, swalpamycin, has been isolated from the culture broth of Streptomyces sp. Y-84, 30967. Taxonomically the producing organism most closely resembles Streptomyces anandii and has therefore been named S. anandii subsp. swalpus. Swalpamycin is a neutral 16-membered macrolide active against Gram-positive bacteria including erythromycin-resistant strains.抄録全体を表示PDF形式でダウンロード (573K) -
II. STRUCTURE ELUCIDATIONSUGATA CHATTERJEE, GOUKANAPALLI C. S. REDDY, CHRISTOPHER M. M. FRANCO, ...1987 年 40 巻 10 号 p. 1368-1374
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーA new antibiotic swalpamycin (1) has been isolated from the culture broth of Streptomyces sp. Y-84, 30967. The antibiotic has the molecular formula of C37H56O14 and belongs to the class of 16-membered neutral macrolide antibiotics. Its structure has been elucidated by an analysis of its spectral properties. It contains a novel aglycone herein called swalpanolide.抄録全体を表示PDF形式でダウンロード (384K) -
I. TAXONOMY, FERMENTATION AND BIOLOGICAL PROPERTIESMARIANNA JACKSON, JAMES P. KARWOWSKI, ROBERT J. THERIAULT, PRABHAVATHI ...1987 年 40 巻 10 号 p. 1375-1382
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーColoradocin was discovered in a screen for anti-anaerobe activity. The producing organism was determined to be a new species of Actinoplanes, designated Actinoplanes coloradoensis sp. nov. Coloradocin inhibits Bacteroides, Clostridium and other anaerobes. It does not inhibit most aerobic bacteria but is effective against Neisseria gonorrhoeae and Haemophilus influenzae. Coloradocin has low acute toxicity.抄録全体を表示PDF形式でダウンロード (500K) -
II. IDENTITY WITH LUMINAMICIN AND ELUCIDATION OF STRUCTURERONALD R. RASMUSSEN, MICHAEL H. SCHERR, DAVID N. WHITTERN, ALEX M. BUK ...1987 年 40 巻 10 号 p. 1383-1393
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーColoradocin was isolated from a fermentation broth by adsorption onto Amberlite XAD-2. The activity was eluted in MeOH and purified by gel filtration on Shephadex LH-20, followed by liquid-liquid chromatography on diol-bonded silica gel. The last two steps in the purification of this antibiotic included reverse-phase chromatography on CIS-bonded silica gel and countercurrent chromatography on an Ito Coil Planet Centrifuge to give material of 90% purity. Analytically pure material was obtained by preparative HPLC. As a result of extensive homo and heteronuclear two-dimensional NMR studies, a structure was proposed for coloradocin. The structure consists of a decalin ring system fused to a 10-membered macrolactone which in turn is fused to a 14-membered macrolactone possessing an enol ether in conjugation with an unsaturated cyclic anhydride functionality. Coloradocin is related to a small class of antibiotics which include nodusmicin and nargenicin and was shown to be identical to luminamicin for which no structure has been reported.抄録全体を表示PDF形式でダウンロード (558K) -
I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATIONMOTOAKI NISHIKAWA, YASUHISA TSURUMI, TAKAYUKI NAMIKI, KEIZO YOSHIDA, M ...1987 年 40 巻 10 号 p. 1394-1399
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーWF-3681 was isolated from a cultured filtrate of Chaetomella raphigera as a novel inhibitor of aldose reductase. It was extracted with ethyl acetate and then purified with silica gel chromatography. Its molecular formula was determined to be C13H12O5 by elemental analysis and high resolution electron impact mass spectrometry. IC50 of WF-3681 was 2.5×10-7 M for partially purified aldose reductase of rabbit lens.抄録全体を表示PDF形式でダウンロード (560K) -
II. STRUCTURE DETERMINATION AND SYNTHESISTAKAYUKI NAMIKI, MOTOAKI NISHIKAWA, YOSHIKUNI ITOH, ITSUO UCHIDA, MASA ...1987 年 40 巻 10 号 p. 1400-1407
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーThe structure of WF-3681, a novel aldose reductase inhibitor produced by Chaetomella raphigera Swift No. 3681, was deduced to be 1 on the basis of its spectroscopic and chemical evidences and confirmed by a total synthesis starting from (E)-5-phenyl-4-pentenol.抄録全体を表示PDF形式でダウンロード (566K) -
FERMENTATION, ISOLATION AND STRUCTURE ELUCIDATIONMAHESH PATEL, VINCENT P. GULLO, VINOD R. HEGDE, ANN C. HORAN, FRANK GE ...1987 年 40 巻 10 号 p. 1408-1413
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーA novel tetracycline antibiotic, Sch 33256, was isolated from a culture broth of a new species of Actinomadura. The antibiotic was isolated by solvent extraction, Sephadex G-25 column chromatography and crystallization. The structure was determined by comparison of the spectra with that of chlortetracycline. Spectroscopic analysis of the compound yielded 2'-N-methyl-8-methoxychlortetracycline as the proposed structure.抄録全体を表示PDF形式でダウンロード (290K) -
FERMENTATION, ISOLATION AND STRUCTURE ELUCIDATIONMAHESH PATEL, VINCENT P. GULLO, VINOD R. HEGDE, ANN C. HORAN, JOSEPH A ...1987 年 40 巻 10 号 p. 1414-1418
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーAn actinomycete identified as a Dactylosporangium sp. produces a new tetracycline, 4ahydroxy-8-methoxychlortetracycline (Sch 34164). The addition of magnesium ions to complex fermentation media increased the antibiotic titers. Sch 34164 was isolated by solvent extraction and Sephadex G-25 column chromatography. The novel structure was proposed based on spectroscopic analysis. The shift of C-4a (35 to 77 ppm) and C-8 (140 to 163 ppm) in the 13C NMR as compared to chlortetracycline was indicative of the novel hydroxyl and methoxy substituents, respectively.抄録全体を表示PDF形式でダウンロード (246K) -
ISOLATION OF A THIRD 8-METHOXY SUBSTITUTED CHLORTETRACYCLINEELIZABETH B. SMITH, HANAN K. MUNAYYER, MICHAEL J. RYAN, B. ALLEN MAYLE ...1987 年 40 巻 10 号 p. 1419-1425
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーActinomadura brunnea produces 2'-N-methyl-8-methoxychlortetracycline. A derivative of this strain has been isolated that is specifically blocked in methylation of the 2'-amino position. This isolate was detected by screening approximately 30, 000 colonies of a mutagenized population of Actinomadura brunnea using a direct soft agar overlay with an Escherichia coli indicator. The antibiotic produced by the blocked mutant has been identified as 8-methoxychlortetracycline (Sch 36969) based upon its biological activity, relative mobility on TLC and HPLC, and spectroscopic data.抄録全体を表示PDF形式でダウンロード (607K) -
A. CACCIAPUOTI, E. L. Moss, F. MENZEL, C. ADAM CRAMER, W. WEISS, D. LO ...1987 年 40 巻 10 号 p. 1426-1430
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーThe in vitro activities of three new 8-methoxychlortetracyclines, Sch 36969, 33256 and 34164 were compared to tetracycline, minocycline and doxycycline. Against aerobic Gramnegative rods Sch 36969 had a geometric mean MIC (GMM) of 4.2 μg/ml, about 8-fold more potent than Sch 33256, and similar to all the other compounds. Sch 36969 also had good activity against methicillin-resistant (GMM, 0.21 μg/ml) and -susceptible Staphylococci (GMM, 0.14 μg/ml), Streptococci (GMM, 0.06 μg/ml), and most anaerobic bacteria (GMM, <0.5 μg/ml). In general, Sch 36969 was similar to, or more potent than, all the other compounds tested. Serum levels of Sch 36969 in squirrel monkeys were 4-fold lower (AUC, 4.5 μg•hours/ml) than those of chlortetracycline (AUC, 16.1 μg•hours/ml). In mouse protection tests (PD50s) against various strains of bacteria, Sch 36969 was similar in activity to tetracycline, but up to 6-fold less active than chlortetracycline. The structure activity relationships for these new chlortetracyclines are described.抄録全体を表示PDF形式でダウンロード (306K) -
BACIMETHRIN ISOLATED FROM STREPTOMYCES ALBUS IDENTIFICATION, DERIVATIVES, SYNTHESIS AND BIOLOGICAL PROPERTIESHANNELORE DRAUTZ, WERNER MESSERER, HANS ZÄHNER, SABINE BREIDING-M ...1987 年 40 巻 10 号 p. 1431-1439
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーBacimethrin (1), known as a thiamine antagonist produced by Bacillus megatherium, was isolated from Streptomyces albus and has been further characterized by NMR spectra and acetylation. A new easy three step synthesis for 1 is described. The biological activity of 1, and its mode of action were discussed. There are indications that bacimethrin inhibits the phosphorylation of 4-amino-5-hydroxymethyl-2-methylpyrimidme (Pyr-OH) during thiamine biosynthesis.抄録全体を表示PDF形式でダウンロード (583K) -
TAICHI MANOME, EMIKO HOSHINO1987 年 40 巻 10 号 p. 1440-1447
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーThe thiostrepton-resistance gene is expressed in Streptomyces jumonjinensis [16]-8 SANK 61185 carrying the plasmid pIJ702 but not the tyrosinase gene. We have isolated DNA fragments from various streptomycetes that restore expression of the tyrosinase gene on pIJ702 in this organism. The nucleotide sequences of two of these DNA fragments show that they contain putative ribosome binding sites and -10 regions of possible promoters.抄録全体を表示PDF形式でダウンロード (657K) -
KYUICHI NEMOTO, MICHIKO HAYASHI, JUNPEI ITO, FUMINORI ABE, TOMOHISA TA ...1987 年 40 巻 10 号 p. 1448-1451
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーWe investigated the effect of spergualin (SGL) upon the development of spontaneous systemic lupus erythematosus-like lesions in male MRL/MpJ-lpr/lpr mice. SGL was administered ip at doses of 2.5, 5 and 10 mg/kg to two groups of mice. One group received SGL prophylactically from 7 to 21 weeks of age. The other group received SGL curatively from 13 to 27 weeks of age. The occurrence of lupus lesions was characterized by enlarged lymphoid organs, high anti-DNA titer and blood urea nitrogen, and severe glomerular nephritis. In both groups these characteristics were significantly suppressed by SGL in a dosedependent manner. This inhibitory activity was greatest at a dose of 10 mg/kg. These findings suggest that SGL has prophylactic and curative effects against lupus lesions in autoimmune disease in mice.抄録全体を表示PDF形式でダウンロード (228K) -
ICHIHIKO YAMAMOTO, MASAYA NAKAGAWA, YOICHI HAYAKAWA, KAZUYOSHI ADACHI, ...1987 年 40 巻 10 号 p. 1452-1454
発行日: 1987/10/25
公開日: 2006/04/19
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HUBERT MAEHR, RALPH H. EVANS1987 年 40 巻 10 号 p. 1455-1456
発行日: 1987/10/25
公開日: 2006/04/19
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HIROSHI TOMODA, KAZUAKI IGARASHI, YOSHITAKE TANAKA, SATOSHI OMURA1987 年 40 巻 10 号 p. 1457-1460
発行日: 1987/10/25
公開日: 2006/04/19
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KUNIO ISSHIKI, YOSHIKAZU TAKAHASHI, HIRONOBU IINUMA, HIROSHI NAGANAWA, ...1987 年 40 巻 10 号 p. 1461-1463
発行日: 1987/10/25
公開日: 2006/04/19
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TAKAYUKI USUI, SUMIO UMEZAWA1987 年 40 巻 10 号 p. 1464-1467
発行日: 1987/10/25
公開日: 2006/04/19
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YOSHIO HAMASHIMA, TADATOSHI KUBOTA, KYOJI MINAMI, KOJI ISHIKURA, TOSHI ...1987 年 40 巻 10 号 p. 1468-1470
発行日: 1987/10/25
公開日: 2006/04/19
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MASAYA IMOTO, KAZUO UMEZAWA, KUNIO ISSHIKI, SETSUKO KUNIMOTO, TSUTOMU ...1987 年 40 巻 10 号 p. 1471-1473
発行日: 1987/10/25
公開日: 2006/04/19
ジャーナル フリーPDF形式でダウンロード (205K)
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