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TOSHIHIRO SHIBATA, OSAMU NAKAYAMA, MASAKUNI OKUHARA, YASUHISA TSURUMI, ...
1988 Volume 41 Issue 9 Pages
1163-1169
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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FR-900490 is a new type of immunoactive substance produced by a fungus
Discosia sp. F-11809.
The colony forming units in culture (cfu-c) in bone marrow cells, which were suppressed by immunosuppressive factor obtained from the serum of sarcoma 180 tumor bearing mouse, was restored to normal level by the addition of FR-900490
in vitro. Furthermore, in mitomycin C (MMC)-treated mice the subsequent administration of FR-900490 caused a significant increase of cfu-c in bone marrow cells depressed by MMC.
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TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION
STEPHEN H. LARSEN, LA VERNE D. BOECK, FREDERICK P. MERTZ, JONATHAN W. ...
1988 Volume 41 Issue 9 Pages
1170-1177
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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16-Deethylindanomycin (A83094A) is a novel pyrrole-ether antibiotic produced by a strain of
Streptomyces setonii. The antibiotic, which is structurally similar to indanomycin (X-14547A), is active in vitro against Gram-positive bacteria as well as coccidia.
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I. ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES
RALPH GROTE, AXEL ZEECK, HANNELORE DRAUTZ, HANS ZÄHNER
1988 Volume 41 Issue 9 Pages
1178-1185
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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The yellow colabomycins A to C, three new antibiotics of the manumycin group produced by
Streptomyces griseoflavus (strain Tü 2880), were detected by chemical screening. They were isolated from mycelium extracts by column chromatography on various adsorbents, followed by preparative reversed phase HPLC. The main compound, colabomycin A (
1), was characterized and shown to be chiefly biologically active against Gram-positive bacteria and stem cells of murine L1210 leukemia.
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II. STRUCTURE OF COLABOMYCIN A
RALPH GROTE, AXEL ZEECK, JOHN M. BEALE
1988 Volume 41 Issue 9 Pages
1186-1195
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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The structure of colabomycin A (
1) was elucidated by a detailed spectroscopic analysis. Two-dimensional NMR spectroscopy experiments provided assignments of the proton and carbon resonances of the tetraene carboxamide chains occurring in
1. The configurations of eight out of nine double bonds were determined by analysis of their coupling constants. The absolute configurations of C-4 (4
S), C-5 (5
R) and C-6 (6
S) were established from the CD spectra of the parent compound and of 2-(6-oxo-2, 4-hexadienoylamino)-5, 6-epoxy-1, 4-benzoquinone (
2), which was obtained from
1 by mild chromic acid oxidation.
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SATORU KONDO, KAZUHISA YASUI, MASAHIRO NATSUME, MASATO KATAYAMA, SHING ...
1988 Volume 41 Issue 9 Pages
1196-1204
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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Pamamycin-607, which showed aerial mycelium-inducing activity, has been isolated from
Streptomyces alboniger IFO 12738. At 0.1 μg/disc it induces aerial mycelia in the aerial mycelium-negative strain of S. alboniger but inhibits growth of the substrate mycelia at 10 μg/disc. It also acts as an antibiotic against some fungi and bacteria. When KMnO
4 was partitioned with pamamycin-607 between benzene and water, MnO
4- but no K
+ was transferred from the water to the benzene layer; pamamycin-607 was thus shown to be a novel anion-transfer antibiotic.
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I. TAXONOMY OF THE PRODUCING CULTURE, FERMENTATION AND BIOLOGICAL ACTIVITY
J. P. KARWOWSKI, M. JACKSON, R. J. THERIAULT, J. F. PROKOP, M. L. MAUS ...
1988 Volume 41 Issue 9 Pages
1205-1211
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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The arizonins, a novel complex of antibiotics related to kalafungin, were discovered in the fermentation broth of
Actinoplanes sp. AB660D-122. Comparative taxonomic studies indicated that the culture is a new species and therefore has been designated
Actinoplanes arizonaensis sp. nov. Two members of the complex, arizonins A1 and B1, exhibit moderate to potent
in vitro antimicrobial activity against pathogenic strains of Gram-positive bacteria.
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A. D. ARGOUDELIS, L. BACZYNSKYJ, S. A. MIZSAK, F. B. SHILLIDAY, P. F. ...
1988 Volume 41 Issue 9 Pages
1212-1222
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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Senfolomycins A and B (Antimicrob. Agents Chemother. -1965: 828-831, 1966) are two antibacterial agents with physico-chemical and biological properties similar to those of paulomycin. Recent studies indicate that senfolomycin A (C
29H
36N
2O
16S, MW 700) has molecular composition and fast atom bombardment MS fragmentation pattern identical to those of paulomycin E. Extensive NMR work indicates that the two antibiotics, which have been separated by HPLC and TLC, differ only in the stereochemistry of the OCH
3 group present in their respective sugar moieties. Indirect evident suggests that senfolomycin B is dihydrosenfolomycin A (C
29H
38N
2O
16S, MW 702) and in this respect it is related to paulomycin F. The proposed structures for senfolomycins A and B are discussed.
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SHINJI FUNAYAMA, YUMI ANRAKU, AKIRA MITA, Zm-Bo YANG, KIYOSHI SHIBATA, ...
1988 Volume 41 Issue 9 Pages
1223-1230
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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Various derivatives of trienomycin A (
1) were prepared and tested for cytocidal activities. All the derivatives except for 22-
O-methyltrienomycin A (
5) showed reduced cytotoxicity compared with
1. It is concluded that the existence of a triene moiety, free 13-OH and an acyl group at C-11 owe important role for cytocidal activity.
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BARRIE W. BYCROFT, CHRISTOPHER MASLEN, STEPHEN J. Box, ALLAN BROWN, JO ...
1988 Volume 41 Issue 9 Pages
1231-1242
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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Two new β-lactams have been isolated from strains of
Serratia and
Erwinia sp. and identified as (3
R, 5
R)- and (3
S, 5
R)-carbapenam-S-carboxylic acid. These novel carbapenams lack antibacterial activity, are resistant to both β-lactamases I and II from
Bacillus cereus and are not detected by the lactamase induction assay. Radiolabelled and stable isotope experiments have established that both metabolites together with the antibiotic 5
R-carbapenem-3-carboxylic acid are glutamate and acetate derived. A number of possible pathways for the biosynthesis of these compounds as well as their relationship to the more complex members of the carbapenem family of β-lactam antibiotics are discussed.
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ENRICO SELVA, BETH P. GOLDSTEIN, PIETRO FERRARI, ROSA PALLANZA, ERNEST ...
1988 Volume 41 Issue 9 Pages
1243-1252
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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A40926 antibiotics are new glycopeptides which are much more active than other members of this class against
Neisseria gonorrhoeae. Their activity against Gram-positive bacteria, including coagulase-negative Staphylococci, is similar to that of other glycopeptides. An A40926 preparation containing factors A and B ("A40926 A+B complex") was hydrolyzed to the aglycone and to the mannosyl and
N-acylaminoglucuronyl aglycones. The mannosyl aglycone and the aglycone were less active than A40926 A+B complex against Streptococci and Gram-positive anaerobes and lost the anti-gonorrheal activity. In contrast, the
N-acylaminoglucuronyl aglycones were as active as the parent complex against these Gram-positive bacteria and were moderately active against
N.
gonorrhoeae. The aglycone and, even more so, the
N-acylaminoglucuronyl aglycones, had better activity than the parent complex against coagulase-negative Staphylococci. In experimental septicemia in the mouse, A40926 A+B complex and its derivatives had activity proportional to their MIC for the test organism.
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KYUICHI NEMOTO, MICHIKO HAYASHI, YUMI SUGAWARA, JUNPEI ITO, FUMINORI A ...
1988 Volume 41 Issue 9 Pages
1253-1259
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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An assessment of the prophylactic and ameliorative effects of deoxyspergualin (NKT-01), an immunosuppressive agent, was carried out in male MRL/MpJ-1pr/1pr (MRL/1) mice which spontaneously develop lupus-like lesions. When NKT-01 was administered ip daily from the age of either 8 or 19 weeks, diseases such as massive lymphadenopathy, circulating anti-DNA antibody and lupus nephritis were markedly suppressed. The primary response to lipopolysaccharide was significantly reduced in MRL/1 mice administered NKT-01 but the response to sheep red blood cells was not affected. The ability of spleen cells to release interleukins 2 and 3 with or without mitogen was significantly enhanced in mice receiving NKT-01. These findings demonstrate that NKT-01 has therapeutic activity against the development of spontaneous disease in MRL/1 mice.
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YASUHIRO SHIGIHARA, YUMI KOIZUMI, TSUYOSHI TAMAMURA, YOSHIKO HOMMA, KU ...
1988 Volume 41 Issue 9 Pages
1260-1264
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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SADAO SATO, YOJI FURUKAWA
1988 Volume 41 Issue 9 Pages
1265-1267
Published: September 25, 1988
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P. R. DAS, B. N. PRAMANIK, V. M. GIRIJAVALLABHAN, A. K. GANGULY
1988 Volume 41 Issue 9 Pages
1268-1271
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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KIYOTO EDO, YURIKO AKIYAMA-MURAI, KUNIHITO SAITO, MICHINAO MIZUGAKI, Y ...
1988 Volume 41 Issue 9 Pages
1272-1274
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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RALPH GROTE, AXEL ZEECK, HANNELORE DRAUTZ, HANS ZÄHNER
1988 Volume 41 Issue 9 Pages
1275-1276
Published: September 25, 1988
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TAKESHI YAMADA
1988 Volume 41 Issue 9 Pages
1277-1280
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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JIRO ITOH, HIRO-OMI WATABE, SHIGETAKA ISHII, SHUICHI GOMI, MIEKO NAGAS ...
1988 Volume 41 Issue 9 Pages
1281-1284
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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MICHIO ICHIMURA, KENICHI MUROI, Kozo ASANO, ISAO KAWAMOTO, FUSAO TOMIT ...
1988 Volume 41 Issue 9 Pages
1285-1288
Published: September 25, 1988
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J. ZIELINSKI, J. GOLIK, J. PAWLAK, E. BOROWSKI, L. FALKOWSKI
1988 Volume 41 Issue 9 Pages
1289-1291
Published: September 25, 1988
Released on J-STAGE: April 19, 2006
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